Browsing by Author "Catteruccia, Flaminia"
Now showing items 1-14 of 14
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Concerning RNA-guided gene drives for the alteration of wild populations
Esvelt, Kevin M; Smidler, Andrea L; Catteruccia, Flaminia; Church, George M (eLife Sciences Publications, Ltd, 2014)Gene drives may be capable of addressing ecological problems by altering entire populations of wild organisms, but their use has remained largely theoretical due to technical constraints. Here we consider the potential for ... -
Dihydroisoxazole inhibitors of Anopheles gambiae seminal transglutaminase AgTG3
Le, Binh V; Klöck, Cornelius; Schatz, Alexandra; Nguyen, Jennifer B; Kakani, Evdoxia G; Catteruccia, Flaminia; Khosla, Chaitan; Baxter, Richard HG (BioMed Central, 2014)Background: Current vector-based malaria control strategies are threatened by the rise of biochemical and behavioural resistance in mosquitoes. Researching mosquito traits of immunity and fertility is required to find ... -
Disrupting Mosquito Reproduction and Parasite Development for Malaria Control
Childs, Lauren M.; Cai, Francisco Y.; Kakani, Evdoxia G.; Mitchell, Sara N.; Paton, Doug; Gabrieli, Paolo; Buckee, Caroline O.; Catteruccia, Flaminia (Public Library of Science, 2016)The control of mosquito populations with insecticide treated bed nets and indoor residual sprays remains the cornerstone of malaria reduction and elimination programs. In light of widespread insecticide resistance in ... -
Engineering the control of mosquito-borne infectious diseases
Gabrieli, Paolo; Smidler, Andrea; Catteruccia, Flaminia (BioMed Central, 2014)Recent advances in genetic engineering are bringing new promise for controlling mosquito populations that transmit deadly pathogens. Here we discuss past and current efforts to engineer mosquito strains that are refractory ... -
Evidence of natural Wolbachia infections in field populations of Anopheles gambiae
Baldini, Francesco; Segata, Nicola; Pompon, Julien; Marcenac, Perrine; Robert Shaw, W.; Dabiré, Roch K.; Diabaté, Abdoulaye; Levashina, Elena A.; Catteruccia, Flaminia (Nature Pub. Group, 2014)Wolbachia are maternally transmitted intracellular bacteria that invade insect populations by manipulating their reproduction and immunity and thus limiting the spread of numerous human pathogens. Experimental Wolbachia ... -
Exposing Anopheles mosquitoes to antimalarials blocks Plasmodium parasite transmission
Paton, Douglas; Itoe, Maurice; Holmdahl, Inga; Buckee, Caroline; Catteruccia, Flaminia (Springer Nature, 2019-02-27)Every year the bites of Anopheles mosquitoes kill hundreds of thousands of people, mostly young African children, by transmitting deadly Plasmodium falciparum malaria parasites. Since the turn of the century, efforts to ... -
High-throughput Sorting of Mosquito Larvae for Laboratory Studies and for Future Vector Control Interventions
Marois, Eric; Scali, Christina; Soichot, Julien; Kappler, Christine; Levashina, Elena A; Catteruccia, Flaminia (BioMed Central, 2012)Background: Mosquito transgenesis offers new promises for the genetic control of vector-borne infectious diseases such as malaria and dengue fever. Genetic control strategies require the release of large number of male ... -
The Interaction between a Sexually Transferred Steroid Hormone and a Female Protein Regulates Oogenesis in the Malaria Mosquito Anopheles gambiae
Baldini, Francesco; Gabrieli, Paolo; South, Adam; Valim, Clarissa; Mancini, Francesca; Catteruccia, Flaminia (Public Library of Science, 2013)Molecular interactions between male and female factors during mating profoundly affect the reproductive behavior and physiology of female insects. In natural populations of the malaria mosquito Anopheles gambiae, blood-fed ... -
A male steroid controls female sexual behaviour in the malaria mosquito
Peng, Duo; Kakani, Evdoxia; Mameli, Enzo; Vidoudez, Charles; Mitchell, Sara; Merrihew, Gennifer E.; MacCoss, Michael J.; Adams, Kelsey; Rinvee, Tasneem A.; Shaw, W. Robert; Catteruccia, Flaminia (Springer Science and Business Media LLC, 2022-07-06)Insects, unlike vertebrates, are widely believed to lack male-biased sex steroid hormones1. In the malaria mosquito Anopheles gambiae, the ecdysteroid 20-hydroxyecdysone (20E) appears to have evolved to both control egg ... -
The reproductive tracts of two malaria vectors are populated by a core microbiome and by gender- and swarm-enriched microbial biomarkers
Segata, Nicola; Baldini, Francesco; Pompon, Julien; Garrett, Wendy S.; Truong, Duy Tin; Dabiré, Roch K.; Diabaté, Abdoulaye; Levashina, Elena A.; Catteruccia, Flaminia (Nature Publishing Group, 2016)Microbes play key roles in shaping the physiology of insects and can influence behavior, reproduction and susceptibility to pathogens. In Sub-Saharan Africa, two major malaria vectors, Anopheles gambiae and An. coluzzii, ... -
Selection at Work in Plasmodium Falciparum: Lessons From the Expanded Acyl CoA Synthetase Gene Family and in Vitro Artemisinin Resistance.
Demas, Allison Ross (2016-05-18)Approximately one third of the world’s population is at risk of contracting malaria. The World Health Organization estimates there were over 200 million news cases of malaria in 2015, resulting in nearly 500,000 deaths ... -
Sialic acid variation as a determinant of Plasmodium invasion of erythrocytes in malaria infection
Dankwa, Selasi (2015-05-18)Sialic acids are acidic sugars that terminate glycan chains on proteins or lipids on vertebrate cell surfaces. They vary greatly in structure, presentation and amount, all of which are important physiologically, but can ... -
Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles
Werling, Kristine; Shaw, William; Itoe, Maurice; Westervelt, Kathleen; Marcenac, Perrine; Paton, Douglas; Peng, Duo; Singh, Naresh; Smidler, Andrea L.; South, Adam; Deik, Amy; Mancio-Silva, Liliana; Demas, Allison R.; March, Sandra; Calvo, Eric; Bhatia, Sangeeta; Clish, Clary B.; Catteruccia, Flaminia (Elsevier BV, 2019-04)Transmission of malaria parasites occurs when a female Anopheles mosquito feeds on an infected host to acquire nutrients for egg development. How parasites are affected by oogenetic processes, principally orchestrated by ... -
Wolbachia infections in natural Anopheles populations affect egg laying and negatively correlate with Plasmodium development
Shaw, W. Robert; Marcenac, Perrine; Childs, Lauren M.; Buckee, Caroline O.; Baldini, Francesco; Sawadogo, Simon P.; Dabiré, Roch K.; Diabaté, Abdoulaye; Catteruccia, Flaminia (Nature Publishing Group, 2016)The maternally inherited alpha-proteobacterium Wolbachia has been proposed as a tool to block transmission of devastating mosquito-borne infectious diseases like dengue and malaria. Here we study the reproductive manipulations ...