Browsing by Author "Loveland, Anna Barbara"
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Bypass of a protein roadblock by a replicative DNA helicase
Yardimci, Hasan; Wang, Xindan; Loveland, Anna B.; Tappin, Inger; Rudner, David Z.; Hurwitz, Jerard; van Oijen, Antoine M.; Walter, Johannes C. (2012)Replicative DNA helicases generally unwind DNA as a single hexamer that encircles and translocates along one strand of the duplex while excluding the complementary strand (“steric exclusion”). In contrast, large T antigen ... -
Single-Molecule Studies of Eukaryotic DNA Replication
Loveland, Anna Barbara (2013-02-14)DNA replication is a fundamental cellular process. However, the structure and dynamics of the eukaryotic DNA replication machinery remain poorly understood. A soluble extract system prepared from Xenopus eggs recapitulates ...