Browsing by Author "Birkbak, N"
Now showing items 1-5 of 5
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A Breast Cancer Meta-Analysis of Two Expression Measures of Chromosomal Instability Reveals a Relationship with Younger Age at Diagnosis and High Risk Histopathological Variables
Endesfelder, David; McGranahan, Nicholas; Birkbak, Nicolai Juul; Szallasi, Zoltan; Kschischo, Maik; Graham, Trevor A.; Swanton, Charles (Impact Journals LLC, 2011)Breast cancer in younger patients often presents with adverse histopathological features, including increased frequency of estrogen receptor negative and lymph node positive disease status. Chromosomal instability (CIN) ... -
Jetset: Selecting the Optimal Microarray Probe Set to Represent a Gene
Li, Qiyuan; Birkbak, Nicolai Juul; Gyorffy, Balazs; Szallasi, Zoltan; Eklund, Aron C (BioMed Central, 2011)Background: Interpretation of gene expression microarrays requires a mapping from probe set to gene. On many Affymetrix gene expression microarrays, a given gene may be detected by multiple probe sets, which may deliver ... -
MECP2 Is a Frequently Amplified Oncogene with a Novel Epigenetic Mechanism That Mimics the Role of Activated RAS in Malignancy
Neupane, Manish; Clark, Allison Paige; Landini, S.; Birkbak, N; Eklund, A. C.; Lim, E.; Culhane, Aedin; Barry, William T.; Schumacher, Sandra Kay; Beroukhim, Rameen; Szallasi, Zoltan; Vidal, Marc; Hill, David E.; Silver, Daniel P. (American Association for Cancer Research (AACR), 2015)An unbiased genome-scale screen for unmutated genes that drive cancer growth when overexpressed identified MECP2 as a novel oncogene. MECP2 resides in a region of the Xchromosome that is significantly amplified across 18% ... -
Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome
Wang, Z. C.; Birkbak, N; Culhane, Aedin; Drapkin, R; Fatima, Aquila; Tian, R; Schwede, M.; Alsop, K.; Daniels, K. E.; Piao, H.; Liu, Joy; Etemadmoghadam, D.; Miron, A; Salvesen, H. B.; Mitchell, G.; DeFazio, A.; Quackenbush, John; Berkowitz, Ross Stuart; Iglehart, James Dirk; Bowtell, D. D. L.; Matulonis, Ursula Anne (American Association for Cancer Research (AACR), 2012)Purpose—High-grade serous cancer (HGSC) is the most common cancer of the ovary and is characterized by chromosomal instability. Defects in homologous recombination repair (HRR) are associated with genomic instability in ... -
STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF- B to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes
Xiang, Michael; Birkbak, Nicolai Juul; Vafaizadeh, V.; Walker, Sarah Rebecca; Yeh, Jennifer E; Liu, Suhu; Kroll, Yasmin; Boldin, M.; Taganov, K.; Groner, B.; Richardson, Andrea Lynn; Frank, David Alan (American Association for the Advancement of Science (AAAS), 2014)Interleukin-6 (IL-6)–mediated activation of signal transducer and activator of transcription 3 (STAT3) is a mechanism by which chronic inflammation can contribute to cancer and is a common oncogenic event. We discovered a ...