Now showing items 1-5 of 5

    • Integrated Proteomic Analysis of Human Cancer Cells and Plasma from Tumor Bearing Mice for Ovarian Cancer Biomarker Discovery 

      Pitteri, Sharon J.; JeBailey, Lellean; Faça, Vitor M.; Thorpe, Jason D.; Silva, Melissa A.; Ireton, Reneé C.; Horton, Marc B.; Pruitt, Liese C.; Urban, Nicole; Hanash, Samir M.; Nordheim, Alfred; Wang, Hong; Zhang, Qing; Cheng, Yu-Kang; Dinulescu, Daniela M (Public Library of Science, 2009)
      Background: The complexity of the human plasma proteome represents a substantial challenge for biomarker discovery. Proteomic analysis of genetically engineered mouse models of cancer and isolated cancer cells and cell ...
    • A Mouse Plasma Peptide Atlas as a Resource for Disease Proteomics 

      Menon, Rajasree; Deutsch, Eric W; Pitteri, Sharon J; Faca, Vitor M; Newcomb, Lisa F; Bardeesy, Nabeel; Hung, Kenneth E; Jacks, Tyler; Politi, Katerina; Aebersold, Ruedi; Omenn, Gilbert S; States, David J; Hanash, Samir M; Zhang, Qing; Wang, Hong; DePinho, Ronald A.; Dinulescu, Daniela M; Kucherlapati, Raju (BioMed Central, 2008)
      We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have ...
    • A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development 

      Faca, Vitor M; Song, Kenneth S; Krasnoselsky, Alexei L; Newcomb, Lisa F; Plentz, Ruben R; Redston, Mark S; Pitteri, Sharon J; Pereira-Faca, Sandra R; Ireton, Renee C; Katayama, Hiroyuki; Glukhova, Veronika; Phanstiel, Douglas; Brenner, Dean E; Anderson, Michelle A; Misek, David; Scholler, Nathalie; Urban, Nicole D; Barnett, Matt J; Edelstein, Cim; Goodman, Gary E; Thornquist, Mark D; McIntosh, Martin W; Bardeesy, Nabeel; Hanash, Samir M; Wang, Hong; Zhang, Qing; Gurumurthy, Sushma; DePinho, Ronald A. (Public Library of Science, 2008)
      Background: The complexity and heterogeneity of the human plasma proteome have presented significant challenges in the identification of protein changes associated with tumor development. Refined genetically engineered ...
    • Postmenopausal Estrogen and Progestin Effects on the Serum Proteome 

      Pitteri, Sharon J; Hanash, Samir M; Aragaki, Aaron; Amon, Lynn M; Busald Buson, Tina; Paczesny, Sophie; Katayama, Hiroyuki; Johnson, Melissa M; McIntosh, Martin; Wang, Pei; Kooperberg, Charles; Rossouw, Jacques E; Jackson, Rebecca D; Hsia, Judith; Liu, Simin; Martin, Lisa; Prentice, Ross L; Manson, JoAnn Elisabeth; Zhang, Qing; Chen, Lin; Wang, Hong (BioMed Central, 2009)
      Background: Women's Health Initiative randomized trials of postmenopausal hormone therapy reported intervention effects on several clinical outcomes, with some important differences between estrogen alone and estrogen plus ...
    • The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer 

      Zhang, Qing; Yang, Haifeng (Frontiers Research Foundation, 2012)
      The function of tumor suppressor VHL is compromised in the vast majority of clear cell renal cell carcinoma, and its mutations or loss of expression was causal for this disease. pVHL was found to be a substrate recognition ...