Now showing items 1-5 of 5

    • Mutant Induced Pluripotent Stem Cell Lines Recapitulate Aspects of TDP-43 Proteinopathies and Reveal Specific Vulnerability 

      Shaw, Christopher E.; Chandran, Siddharthan; Bilican, B.; Serio, A.; Barmada, S. J.; Nishimura, A. L.; Sullivan, G. J.; Carrasco, M.; Phatnani, P.; Friedman, Brad A.; Puddifoot, C. A.; Story, D.; Fletcher, J.; Park, I. H.; Daley, George Quentin; Wyllie, D. J. A.; Hardingham, G. E.; Finkbeiner, S.; Wilmut, I.; Finkbeiner, S.; Maniatis, Thomas P. (National Academy of Sciences, 2012)
      Transactive response DNA-binding (TDP-43) protein is the dominant disease protein in amyotrophic lateral sclerosis (ALS) and a sub-group of frontotemporal lobar degeneration (FTLD-TDP). Identification of TARDBP mutations ...
    • Protocadherins Mediate Dendritic Self-Avoidance in the Mammalian Nervous System 

      Lefebvre, Julie L.; Kostadinov, Dimitar Vladimirov; Chen, Weisheng V.; Maniatis, Thomas P.; Sanes, Joshua R. (Nature, 2012)
      Dendritic arbors of many neurons are patterned by a process called self-avoidance, in which branches arising from a single neuron repel each other. By minimizing gaps and overlaps within the arbor, self-avoidance facilitates ...
    • The Role of Microglia in Amyotrophic Lateral Sclerosis: Analysis of MicroRNAs 

      Morimoto, Emiko (2012-07-24)
      Amyotrophic lateral sclerosis (ALS) is a progressive adult onset neurodegenerative disease characterized by selective death of the upper and lower motor neurons of the brain and spinal cord. Neuromuscular synapses are ...
    • Single Molecule Imaging of Transcription Factor Binding to DNA in Live Mammalian Cells 

      Gebhardt, Johann Christof manuel; Suter, David Michael; Roy, Rahul; Zhao, Zingqing W.; Chapman, Alec Randolph; Basu, Srinjan; Maniatis, Thomas P.; Xie, Xiaoliang Sunney (Nature Publishing Group, 2013)
      Imaging single fluorescent proteins in living mammalian cells is challenged by out-of-focus fluorescence excitation. To reduce out-of-focus fluorescence we developed reflected light-sheet microscopy (RLSM), a fluorescence ...
    • Stochastic Expression of the Interferon-β Gene 

      Zhao, Mingwei; Zhang, Jiangwen; Phatnani, Hemali; Scheu, Stefanie; Maniatis, Thomas P. (Public Library of Science, 2012)
      Virus infection of mammalian cells induces the production of high levels of type I interferons (IFNα and β), cytokines that orchestrate antiviral innate and adaptive immunity. Previous studies have shown that only a fraction ...