Now showing items 1-12 of 12

    • Activated N-Ras signaling regulates arterial-venous specification in zebrafish 

      Ren, Chun-Guang; Wang, Lei; Jia, Xiao-E; Liu, Yi-Jie; Dong, Zhi-Wei; Jin, Yi; Chen, Yi; Deng, Min; Zhou, Yong; Zhou, Yi; Ren, Rui-Bao; Pan, Wei-Jun; Liu, Ting-Xi (BioMed Central, 2013)
      Background: The aberrant activation of Ras signaling is associated with human diseases including hematological malignancies and vascular disorders. So far the pathological roles of activated Ras signaling in hematopoiesis ...
    • Allergic Lung Inflammation Aggravates Angiotensin II–Induced Abdominal Aortic Aneurysms in Mice 

      Liu, Cong-Lin; Wang, Yi; Liao, Mengyang; Wemmelund, Holger; Ren, Jingyuan; Fernandes, Cleverson; Zhou, Yi; Sukhova, Galina K.; Lindholt, Jes S.; Johnsen, Søren P.; Zhang, Jin-Ying; Cheng, Xiang; Huang, Xiaozhu; Daugherty, Alan; Levy, Bruce David; Libby, Peter; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2015)
    • Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53 

      Sorrells, Shelly; Carbonneau, Seth; Harrington, Erik; Chen, Aye T.; Hast, Bridgid; Milash, Brett; Major, Michael B.; Stewart, Rodney A.; Jette, Cicely; Pyati, Ujwal Jagdeesh; Zon, Leonard Ira; Look, A. Thomas; Zhou, Yi (Public Library of Science, 2012)
      DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought ...
    • Characterization of immune-matched hematopoietic transplantation in zebrafish 

      de Jong, J. L. O.; Burns, Caroline Erter; Chen, A. T.; Pugach, E.; Mayhall, E. A.; Smith, A. C. H.; Feldman, Henry Arthur; Zhou, Yi; Zon, Leonard Ira (American Society of Hematology, 2011)
      Evaluating hematopoietic stem cell (HSC) function in vivo requires a long-term transplantation assay. Although zebrafish are a powerful model for discovering the genetics of hematopoiesis, hematopoietic transplantation ...
    • High-Throughput Cell Transplantation Establishes That Tumor-Initiating Cells Are Abundant in Zebrafish T-Cell Acute Lymphoblastic Leukemia 

      Smith, Alexandra C. H.; Raimondi, Aubrey R.; Salthouse, Chris D.; Ignatius, Myron S; Blackburn, Jessica S; Mizgirev, Igor V.; Storer, Narie Yoo; de Jong, Jill L. O.; Chen, Aye Tin Maung; Zhou, Yi; Revskoy, Sergei; Zon, Leonard Ira; Langenau, David M. (American Society of Hematology, 2010)
      Self-renewal is a feature of cancer and can be assessed by cell transplantation into immune-compromised or immune-matched animals. However, studies in zebrafish have been severely limited by lack of these reagents. Here, ...
    • The Histone Methyltransferase SUV39H1 Suppresses Embryonal Rhabdomyosarcoma Formation in Zebrafish 

      Albacker, Colleen Elizabeth; Storer, Narie Yoo; Langdon, Erin M.; DiBiase, Anthony; Zhou, Yi; Langenau, David M.; Zon, Leonard Ira (Public Library of Science, 2013)
      Epigenetics, or the reversible and heritable marks of gene regulation not including DNA sequence, encompasses chromatin modifications on both the DNA and histones and is as important as the DNA sequence itself. Chromatin-modifying ...
    • Mitochondrial Atpif1 regulates heme synthesis in developing erythroblasts 

      Shah, Dhvanit I; Takahashi-Makise, Naoko; Cooney, Jeffrey D.; Li, Liangtao; Schultz, Iman J.; Pierce, Eric L.; Narla, Anupama; Seguin, Alexandra; Hattangadi, Shilpa M.; Medlock, Amy E.; Langer, Nathaniel B.; Dailey, Tamara A.; Hurst, Slater N.; Faccenda, Danilo; Wiwczar, Jessica M.; Heggers, Spencer K.; Vogin, Guillaume; Chen, Wen; Chen, Caiyong; Campagna, Dean R.; Brugnara, Carlo; Zhou, Yi; Ebert, Benjamin L.; Danial, Nika; Fleming, Mark Daniel; Ward, Diane M.; Campanella, Michelangelo; Dailey, Harry A.; Kaplan, Jerry; Paw, Barry Htin (2012)
      SUMMARY Defects in the availability of heme substrates or the catalytic activity of the terminal enzyme in heme biosynthesis, ferrochelatase (Fech), impair heme synthesis, and thus cause human congenital anemias1,2. The ...
    • A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease 

      Peng, Xiaolan; Dong, M; Ma, L; Jia, X-E; Mao, J; Jin, C; Chen, Y; Gao, L; Liu, X; Ma, K; Wang, L; Du, T; Jin, Y; Huang, Q; Li, K; Zon, Leonard Ira; Liu, T; Deng, M; Zhou, Y; Xi, X; Zhou, Yi; Chen, S (Springer Nature, 2015)
      Controlled self-renewal and differentiation of hematopoietic stem/progenitor cells (HSPCs) are critical for vertebrate development and survival. These processes are tightly regulated by the transcription factors, signaling ...
    • Slc39a7/zip7 Plays a Critical Role in Development and Zinc Homeostasis in Zebrafish 

      Yan, Guang; Zhang, Yuchao; Yu, Junlei; Zhang, Zhuzhen; Wu, Aimin; Yan, Xianghua; Wang, Fudi; Yu, Yu; Zhang, Fan; Zhou, Yi (Public Library of Science, 2012)
      Background: Slc39a7/Zip7, also known as Ke4, is a member of solute carrier family 39 (Slc39a) and plays a critical role in regulating cell growth and death. Because the function of Zip7 in vivo was unclear, the present ...
    • A Splice Site Mutation in Laminin-α2 Results in a Severe Muscular Dystrophy and Growth Abnormalities in Zebrafish 

      Gupta, Vandana; Kawahara, Genri; Myers, Jennifer A.; Chen, Aye T.; Hall, Thomas E.; Manzini, Maria Chiara; Currie, Peter D.; Zhou, Yi; Zon, Leonard Ira; Kunkel, Louis Martens; Beggs, Alan Hendrie (Public Library of Science, 2012)
      Congenital muscular dystrophy (CMD) is a clinically and genetically heterogeneous group of inherited muscle disorders. In patients, muscle weakness is usually present at or shortly after birth and is progressive in nature. ...
    • Zebrafish Globin Switching Occurs in Two Developmental Stages and Is Controlled by the LCR 

      Ganis, Jared Jason; Hsia, Nelson; Trompouki, Eirini; de Jong, Jill L.O.; DiBiase, Anthony; Lambert, Janelle S.; Jia, Zhiying; Sabo, Peter J.; Weaver, Molly; Sandstrom, Richard; Stamatoyannopoulos, John A.; Zhou, Yi; Zon, Leonard Ira (Elsevier BV, 2012)
      Globin gene switching is a complex, highly regulated process allowing expression of distinct globin genes at specific developmental stages. Here, for the first time, we have characterized all of the zebrafish globins based ...
    • Zebrafish orthologs of human muscular dystrophy genes 

      Steffen, Leta S; Guyon, Jeffrey R; Vogel, Emily D; Beltre, Rosanna; Pusack, Timothy J; Zhou, Yi; Zon, Leonard Ira; Kunkel, Louis Martens (BioMed Central, 2007)
      Background: Human muscular dystrophies are a heterogeneous group of genetic disorders which cause decreased muscle strength and often result in premature death. There is no known cure for muscular dystrophy, nor have all ...