Now showing items 1-6 of 6

    • Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo 

      Shu, Yilai; Tao, Yong; Li, Wenyan; Shen, Jun; Wang, Zhengmin; Chen, Zheng-Yi (Hindawi Publishing Corporation, 2016)
      Mammalian inner ear harbors diverse cell types that are essential for hearing and balance. Adenovirus is one of the major vectors to deliver genes into the inner ear for functional studies and hair cell regeneration. To ...
    • A Critical Role for CD8 T Cells in a Nonhuman Primate Model of Tuberculosis 

      Chen, Crystal Y.; Shen, Ling; Zeng, Gucheng; Yao, Shuyun; Shen, Yun; Halliday, Lisa; Fortman, Jeff; McAllister, Milton; Estep, Jim; Vasconcelos, Daphne; Du, George; Porcelli, Steven A.; Larsen, Michelle H.; Jacobs, William R.; Haynes, Barton F.; Letvin, Norman Lee; Huang, Dan; Wang, Richard; Hunt, Robert; Chen, Zheng-Yi (Public Library of Science, 2009)
      The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell–mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman ...
    • Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo 

      Li, Margie; Tao, Yong; Shu, Yilai; LaRochelle, Jonathan R.; Steinauer, Angela; Thompson, David; Schepartz, Alanna; Chen, Zheng-Yi; Liu, David Ruchien (American Chemical Society (ACS), 2015)
      The in efficient delivery of proteins into mammalian cells remains a major barrier to realizing the therapeutic potential of many proteins. We and others have previously shown that superpositively charged proteins are ...
    • Disrupting the Interaction between Retinoblastoma Protein and Raf-1 Leads to Defects in Progenitor Cell Proliferation and Survival during Early Inner Ear Development 

      Li, Wenyan; Sun, Shan; Chen, Yan; Yu, Huiqian; Chen, Zheng-Yi; Li, Huawei (Public Library of Science, 2013)
      The retinoblastoma protein (pRb) is required for cell-cycle exit of embryonic mammalian hair cells but is not required for hair cell fate determination and early differentiation, and this provides a strategy for hair cell ...
    • Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo 

      Zuris, John A.; Thompson, David B.; Shu, Yilai; Guilinger, John P.; Bessen, Jeffrey L.; Hu, Johnny H.; Maeder, Morgan L.; Joung, J. Keith; Chen, Zheng-Yi; Liu, David R. (2014)
      Efficient intracellular delivery of proteins is needed to fully realize the potential of protein therapeutics. Current methods of protein delivery commonly suffer from low tolerance for serum, poor endosomal escape, and ...
    • Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration 

      Lee, Sang Goo; Huang, Mingqian; Obholzer, Nikolaus D.; Sun, Shan; Li, Wenyan; Petrillo, Marco; Dai, Pu; Zhou, Yi; Cotanche, Douglas A.; Megason, Sean G.; Li, Huawei; Chen, Zheng-Yi (Public Library of Science, 2016)
      Unlike mammals, the non-mammalian vertebrate inner ear can regenerate the sensory cells, hair cells, either spontaneously or through induction after hair cell loss, leading to hearing recovery. The mechanisms underlying ...