Browsing by Author "Haining, William"

Now showing items 1-5 of 5

    • CD28 Costimulation Regulates Genome-Wide Effects on Alternative Splicing 

      Butte, Manish J.; Lee, Sun Jung; Jesneck, Jonathan Lee; Keir, Mary E.; Haining, William Nicholas; Sharpe, Arlene Helen (Public Library of Science, 2012)
      CD28 is the major costimulatory receptor required for activation of naïve T cells, yet CD28 costimulation affects the expression level of surprisingly few genes over those altered by TCR stimulation alone. Alternate splicing ...

    • Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis 

      Novershtern, Noa; Subramanian, Aravind; Lawton, Lee N.; Mak, Raymond Heungwing; Haining, William Nicholas; McConkey, Marie E.; Habib, Naomi; Yosef, Nir; Chang, Cindy Hsin-Yu; Shay, Tal; Frampton, Garrett M.; Drake, Adam C.B.; Leskov, Ilya; Nilsson, Bjorn; Preffer, Frederic Ira; Dombkowski, David; Evans, John W.; Liefeld, Ted; Smutko, John S.; Chen, Jianzhu; Friedman, Nir; Young, Richard A.; Golub, Todd Robert; Regev, Aviv; Ebert, Benjamin L. (Elsevier BV, 2011)
      While many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct ...

    • Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity 

      Griffin, Gabriel; Wu, Jingyi; Iracheta-Vellve, Arvin; Patti, James C.; Hsu, Jeffrey; Davis, Thomas; Dele-Oni, Deborah; Du, Peter P.; Halawi, Aya G.; Ishizuka, Jeffrey J.; Kim, Sarah Y.; Klaeger, Susan; Knudsen, Nelson H.; Miller, Brian C.; Nguyen, Tung H.; Olander, Kira E.; Papanastasiou, Malvina; Rachimi, Suzanna; Robitschek, Emily J.; Schneider, Emily; Yeary, Mitchell D.; Zimmer, Margaret; Jaffe, Jacob D.; Carr, Steven A.; Doench, John G.; Haining, William; Yates, Kathleen; Manguso, Robert T.; Bernstein, Bradley (Springer Science and Business Media LLC, 2021-05-05)
      Epigenetic dysregulation is a defining feature of tumorigenesis that has been implicated in immune escape1,2. To identify epigenetic factors that modulate the immune sensitivity of cancer cells, we performed in vivo ...

    • High-throughput Gene Expression Profiling of Memory Differentiation in Primary Human T Cells 

      Haining, William Nicholas; Angelosanto, Jill; Brosnahan, Kathleen; Ross, Kenneth; Hahn, Cynthia; Russell, Kate; Drury, Linda; Norton, Stephanie; Nadler, Lee Marshall; Stegmaier, Kimberly (BioMed Central, 2008)
      Background: The differentiation of naive T and B cells into memory lymphocytes is essential for immunity to pathogens. Therapeutic manipulation of this cellular differentiation program could improve vaccine efficacy and ...

    • The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells 

      Beyaz, Semir; Kim, Ji Hyung; Pinello, Luca; Xifaras, Michael E; Hu, Yu; Huang, Jialiang; Kerenyi, Marc A; Das, Partha Pratim; Barnitz, R Anthony; Herault, Aurelie; Dogum, Rizkullah; Haining, William Nicholas; Yilmaz, Omer Hidir; Passegue, Emmanuelle; Yuan, Guo-Cheng; Orkin, Stuart Holland; Winau, Florian (Springer Nature, 2016)