Browsing by Author "Preffer, Frederic"
Now showing items 1-13 of 13
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Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts
Farris, A.B.; Taheri, D.; Kawai, Tatsuo; Fazlollahi, L.; Wong, Wesley Philip; Tolkoff-Rubin, Nina Ellen; Spitzer, Thomas Richard; Iafrate, Anthony John; Preffer, Frederic Ira; LoCascio, S. A.; Sprangers, B.; Saidman, Susan L.; Smith, Raymond Malcolm; Cosimi, A. Benedict; Sykes, Megan; Sachs, David H.; Colvin, Robert Barnes (Wiley-Blackwell, 2011)An idiopathic capillary leak syndrome (“engraftment syndrome”) often occurs in recipients of hematopoietic cells, manifested clinically by transient azotemia and sometimes fever and fluid retention. Here we report the renal ... -
Advances in complex multiparameter flow cytometry technology: Applications in stem cell research
Preffer, Frederic Ira; Dombkowski, David (Wiley-Blackwell, 2009)Flow cytometry and cell sorting are critical tools in stem cell research. Recent advances in flow cytometric hardware, reagents, and software have synergized to permit the stem cell biologist to more full identify and ... -
Carcinoma and Multiple Lymphomas in One Patient: Establishing the Diagnoses and Analyzing Risk Factors
Cannizzo, Elisa; Sadowski, Craig; Bucci, Janessa J.; Carulli, Giovanni; Sohani, Aliyah; Ferry, Judith Ann; Hochberg, Ephraim Paul; Kluk, Michael Joseph; Dorn, Michelle E.; Ackerman, Adam M.; Longtine, Janina Ann; Preffer, Frederic Ira (Springer-Verlag, 2009)Multiple malignancies may occur in the same patient, and a few reports describe cases with multiple hematologic and non-hematologic neoplasms. We report the case of a patient who showed the sequential occurrence of four ... -
Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis
Novershtern, Noa; Subramanian, Aravind; Lawton, Lee N.; Mak, Raymond Heungwing; Haining, William Nicholas; McConkey, Marie E.; Habib, Naomi; Yosef, Nir; Chang, Cindy Hsin-Yu; Shay, Tal; Frampton, Garrett M.; Drake, Adam C.B.; Leskov, Ilya; Nilsson, Bjorn; Preffer, Frederic Ira; Dombkowski, David; Evans, John W.; Liefeld, Ted; Smutko, John S.; Chen, Jianzhu; Friedman, Nir; Young, Richard A.; Golub, Todd Robert; Regev, Aviv; Ebert, Benjamin L. (Elsevier BV, 2011)While many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct ... -
Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation
Foudi, Adlen; Kramer, Daniel J.; Qin, Jinzhong; Ye, Denise; Behlich, Anna-Sophie; Mordecai, Scott; Preffer, Frederic I.; Amzallag, Arnaud; Ramaswamy, Sridhar; Hochedlinger, Konrad; Orkin, Stuart H.; Hock, Hanno (The Rockefeller University Press, 2014)The zinc finger transcriptional repressor Gfi-1b is essential for erythroid and megakaryocytic development in the embryo. Its roles in the maintenance of bone marrow erythropoiesis and thrombopoiesis have not been defined. ... -
Hematopoietic Stem-Cell Transplantation in the Resource-Limited Setting: Establishing the First Bone Marrow Transplantation Unit in Bangladesh
Yeh, Albert; Khan, Mohiuddin; Harlow, Jason; Biswas, Akhil; Akter, Mafruha; Ferdous, Jannatul; Ara, Tasneem; Islam, Manirul; Caron, Martin; Barron, Anne-Marie; Moran, Jenna; Brezina, Mark; Nazneen, Humayra; Kamruzzaman, Md; Saha, Anup; Marshall, Ariela; Afrose, Salma; Stowell, Christopher; Preffer, Frederic; Bangsberg, David; Goodman, Annekathryn; Attar, Eyal; McAfee, Steven; Spitzer, Thomas; Dey, Bimalangshu (American Society of Clinical Oncology (ASCO), 2018)Purpose: Treatment of malignant and nonmalignant hematologic diseases with hematopoietic stem-cell transplantation (HSCT) was first described almost 60 years ago, and its use has expanded significantly over the last 20 ... -
HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression
Kawai, Tatsuo; Cosimi, A. Benedict; Spitzer, Thomas Richard; Tolkoff-Rubin, Nina Ellen; Suthanthiran, Manikkam; Saidman, Susan L.; Shaffer, Juanita; Preffer, Frederic Ira; Ding, Ruchuang; Sharma, Vijay; Fishman, Jay Alan; Dey, Bimalangshu; Ko, Dicken S.C.; Hertl, Martin; Goes, Nelson B.; Wong, Waichi; Williams, Winfred Woodrow; Colvin, Robert Barnes; Sykes, Megan; Sachs, David H. (New England Journal of Medicine (NEJM/MMS), 2008)Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen. Transient ... -
Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance
Meirelles, K.; Benedict, Lance Mitchell; Dombkowski, D.; Pepin, David; Preffer, Frederic Ira; Teixeira, J; Tanwar, P; Young, Robert Henry; MacLaughlin, D. T.; Donahoe, Patricia; Wei, X. (Proceedings of the National Academy of Sciences, 2012)Women with late-stage ovarian cancer usually develop chemotherapeutic-resistant recurrence. It has been theorized that a rare cancer stem cell, which is responsible for the growth and maintenance of the tumor, is also ... -
Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells
Nishida, Atsushi; Nagahama, Kiyotaka; Imaeda, Hirotsugu; Ogawa, Atsuhiro; Lau, Cindy W.; Kobayashi, Taku; Hisamatsu, Tadakazu; Preffer, Frederic I.; Mizoguchi, Emiko; Ikeuchi, Hiroki; Hibi, Toshifumi; Fukuda, Minoru; Andoh, Akira; Blumberg, Richard S.; Mizoguchi, Atsushi (The Rockefeller University Press, 2012)Immune responses are modified by a diverse and abundant repertoire of carbohydrate structures on the cell surface, which is known as the glycome. In this study, we propose that a unique glycome that can be identified through ... -
MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors
Lu, Jun; Guo, Shangqin; Ebert, Benjamin L.; Zhang, Hao; Peng, Xiao; Bosco, Jocelyn; Pretz, Jennifer Lee; Schlanger, Rita; Wang, Judy Y.; Mak, Raymond Heungwing; Dombkowski, David M.; Preffer, Frederic Ira; Scadden, David Thomas; Golub, Todd Robert (Elsevier BV, 2008)Lineage specification is a critical issue in developmental and regenerative biology. We hypothesized that microRNAs (miRNAs) are important participants in that process and used the poorly-understood regulation of ... -
Mixed Chimerism, Lymphocyte Recovery, and Evidence for Early Donor-Specific Unresponsiveness in Patients Receiving Combined Kidney and Bone Marrow Transplantation to Induce Tolerance
LoCascio, Samuel A.; Morokata, Tatsuaki; Chittenden, Meredith; Preffer, Frederic Ira; Dombkowski, David M.; Andreola, Giovanna; Crisalli, Kerry; Kawai, Tatsuo; Saidman, Susan L.; Spitzer, Thomas Richard; Tolkoff-Rubin, Nina Ellen; Cosimi, A. Benedict; Sachs, David H.; Sykes, Megan (Ovid Technologies (Wolters Kluwer Health), 2010)Background We have previously reported operational tolerance in patients receiving HLA-mismatched combined kidney and bone marrow transplantation (CKBMT). We now report on transient multilineage hematopoietic chimerism ... -
Mullerian inhibiting substance preferentially inhibits stem/progenitors in human ovarian cancer cell lines compared with chemotherapeutics
Wei, X.; Dombkowski, D.; Meirelles, K.; Pieretti-Vanmarcke, R.; Szotek, P. P.; Chang, H; Preffer, Frederic Ira; Mueller, Peter Raff; Teixeira, J; MacLaughlin, D. T.; Donahoe, Patricia (Proceedings of the National Academy of Sciences, 2010)Cancer stem cells are proposed to be tumor-initiating cells capable of tumorigenesis, recurrence, metastasis, and drug resistance, and, like somatic stem cells, are thought to be capable of unlimited self-renewal and, when ... -
Prethymic Cytoplasmic CD3 Negative Acute Lymphoblastic Leukemia or Acute Undifferentiated Leukemia: A Case Report
Cannizzo, Elisa; Carulli, Giovanni; Del Vecchio, Luigi; Azzarà, Antonio; Galimberti, Sara; Ottaviano, Virginia; Preffer, Frederic Ira; Petrini, Mario (Hindawi Publishing Corporation, 2011)Acute undiffentiated leukemia (AUL) is an acute leukemia with no more than one membrane marker of any given lineage. Blasts often express HLA-DR, CD34, and/or CD38 and may be positive for terminal deoxynucleotidyl transferase ...