Now showing items 1-12 of 12

    • Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts 

      Farris, A.B.; Taheri, D.; Kawai, Tatsuo; Fazlollahi, L.; Wong, Wesley Philip; Tolkoff-Rubin, Nina Ellen; Spitzer, Thomas Richard; Iafrate, Anthony John; Preffer, Frederic Ira; LoCascio, S. A.; Sprangers, B.; Saidman, Susan L.; Smith, Raymond Malcolm; Cosimi, A. Benedict; Sykes, Megan; Sachs, David H.; Colvin, Robert Barnes (Wiley-Blackwell, 2011)
      An idiopathic capillary leak syndrome (“engraftment syndrome”) often occurs in recipients of hematopoietic cells, manifested clinically by transient azotemia and sometimes fever and fluid retention. Here we report the renal ...
    • Advances in complex multiparameter flow cytometry technology: Applications in stem cell research 

      Preffer, Frederic Ira; Dombkowski, David (Wiley-Blackwell, 2009)
      Flow cytometry and cell sorting are critical tools in stem cell research. Recent advances in flow cytometric hardware, reagents, and software have synergized to permit the stem cell biologist to more full identify and ...
    • Carcinoma and Multiple Lymphomas in One Patient: Establishing the Diagnoses and Analyzing Risk Factors 

      Cannizzo, Elisa; Sadowski, Craig; Bucci, Janessa J.; Carulli, Giovanni; Sohani, Aliyah; Ferry, Judith Ann; Hochberg, Ephraim Paul; Kluk, Michael Joseph; Dorn, Michelle E.; Ackerman, Adam M.; Longtine, Janina Ann; Preffer, Frederic Ira (Springer-Verlag, 2009)
      Multiple malignancies may occur in the same patient, and a few reports describe cases with multiple hematologic and non-hematologic neoplasms. We report the case of a patient who showed the sequential occurrence of four ...
    • Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis 

      Novershtern, Noa; Subramanian, Aravind; Lawton, Lee N.; Mak, Raymond Heungwing; Haining, William Nicholas; McConkey, Marie E.; Habib, Naomi; Yosef, Nir; Chang, Cindy Hsin-Yu; Shay, Tal; Frampton, Garrett M.; Drake, Adam C.B.; Leskov, Ilya; Nilsson, Bjorn; Preffer, Frederic Ira; Dombkowski, David; Evans, John W.; Liefeld, Ted; Smutko, John S.; Chen, Jianzhu; Friedman, Nir; Young, Richard A.; Golub, Todd Robert; Regev, Aviv; Ebert, Benjamin L. (Elsevier BV, 2011)
      While many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct ...
    • Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation 

      Foudi, Adlen; Kramer, Daniel J.; Qin, Jinzhong; Ye, Denise; Behlich, Anna-Sophie; Mordecai, Scott; Preffer, Frederic I.; Amzallag, Arnaud; Ramaswamy, Sridhar; Hochedlinger, Konrad; Orkin, Stuart H.; Hock, Hanno (The Rockefeller University Press, 2014)
      The zinc finger transcriptional repressor Gfi-1b is essential for erythroid and megakaryocytic development in the embryo. Its roles in the maintenance of bone marrow erythropoiesis and thrombopoiesis have not been defined. ...
    • HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression 

      Kawai, Tatsuo; Cosimi, A. Benedict; Spitzer, Thomas Richard; Tolkoff-Rubin, Nina Ellen; Suthanthiran, Manikkam; Saidman, Susan L.; Shaffer, Juanita; Preffer, Frederic Ira; Ding, Ruchuang; Sharma, Vijay; Fishman, Jay Alan; Dey, Bimalangshu; Ko, Dicken S.C.; Hertl, Martin; Goes, Nelson B.; Wong, Waichi; Williams, Winfred Woodrow; Colvin, Robert Barnes; Sykes, Megan; Sachs, David H. (New England Journal of Medicine (NEJM/MMS), 2008)
      Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen. Transient ...
    • Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance 

      Meirelles, K.; Benedict, Lance Mitchell; Dombkowski, D.; Pepin, David; Preffer, Frederic Ira; Teixeira, J; Tanwar, P; Young, Robert Henry; MacLaughlin, D. T.; Donahoe, Patricia; Wei, X. (Proceedings of the National Academy of Sciences, 2012)
      Women with late-stage ovarian cancer usually develop chemotherapeutic-resistant recurrence. It has been theorized that a rare cancer stem cell, which is responsible for the growth and maintenance of the tumor, is also ...
    • Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells 

      Nishida, Atsushi; Nagahama, Kiyotaka; Imaeda, Hirotsugu; Ogawa, Atsuhiro; Lau, Cindy W.; Kobayashi, Taku; Hisamatsu, Tadakazu; Preffer, Frederic I.; Mizoguchi, Emiko; Ikeuchi, Hiroki; Hibi, Toshifumi; Fukuda, Minoru; Andoh, Akira; Blumberg, Richard S.; Mizoguchi, Atsushi (The Rockefeller University Press, 2012)
      Immune responses are modified by a diverse and abundant repertoire of carbohydrate structures on the cell surface, which is known as the glycome. In this study, we propose that a unique glycome that can be identified through ...
    • MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors 

      Lu, Jun; Guo, Shangqin; Ebert, Benjamin L.; Zhang, Hao; Peng, Xiao; Bosco, Jocelyn; Pretz, Jennifer Lee; Schlanger, Rita; Wang, Judy Y.; Mak, Raymond Heungwing; Dombkowski, David M.; Preffer, Frederic Ira; Scadden, David Thomas; Golub, Todd Robert (Elsevier BV, 2008)
      Lineage specification is a critical issue in developmental and regenerative biology. We hypothesized that microRNAs (miRNAs) are important participants in that process and used the poorly-understood regulation of ...
    • Mixed Chimerism, Lymphocyte Recovery, and Evidence for Early Donor-Specific Unresponsiveness in Patients Receiving Combined Kidney and Bone Marrow Transplantation to Induce Tolerance 

      LoCascio, Samuel A.; Morokata, Tatsuaki; Chittenden, Meredith; Preffer, Frederic Ira; Dombkowski, David M.; Andreola, Giovanna; Crisalli, Kerry; Kawai, Tatsuo; Saidman, Susan L.; Spitzer, Thomas Richard; Tolkoff-Rubin, Nina Ellen; Cosimi, A. Benedict; Sachs, David H.; Sykes, Megan (Ovid Technologies (Wolters Kluwer Health), 2010)
      Background We have previously reported operational tolerance in patients receiving HLA-mismatched combined kidney and bone marrow transplantation (CKBMT). We now report on transient multilineage hematopoietic chimerism ...
    • Mullerian inhibiting substance preferentially inhibits stem/progenitors in human ovarian cancer cell lines compared with chemotherapeutics 

      Wei, X.; Dombkowski, D.; Meirelles, K.; Pieretti-Vanmarcke, R.; Szotek, P. P.; Chang, H; Preffer, Frederic Ira; Mueller, Peter Raff; Teixeira, J; MacLaughlin, D. T.; Donahoe, Patricia (Proceedings of the National Academy of Sciences, 2010)
      Cancer stem cells are proposed to be tumor-initiating cells capable of tumorigenesis, recurrence, metastasis, and drug resistance, and, like somatic stem cells, are thought to be capable of unlimited self-renewal and, when ...
    • Prethymic Cytoplasmic CD3 Negative Acute Lymphoblastic Leukemia or Acute Undifferentiated Leukemia: A Case Report 

      Cannizzo, Elisa; Carulli, Giovanni; Del Vecchio, Luigi; Azzarà, Antonio; Galimberti, Sara; Ottaviano, Virginia; Preffer, Frederic Ira; Petrini, Mario (Hindawi Publishing Corporation, 2011)
      Acute undiffentiated leukemia (AUL) is an acute leukemia with no more than one membrane marker of any given lineage. Blasts often express HLA-DR, CD34, and/or CD38 and may be positive for terminal deoxynucleotidyl transferase ...