Browsing by Author "D'Amore, Patricia"

Now showing items 1-20 of 67

    • Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture. 

      Lipton, S. A.; Wagner, John A.; Madison, Roger D.; D'Amore, Patricia Ann (Proceedings of the National Academy of Sciences, 1988)
      Postnatal rat retinal ganglion cells (RGCs) were identified with specific fluorescent labels and placed in culture. Under these conditions, the outgrowth of processes by RGCs was found to be promoted to a far greater degree ...

    • Adult Human Saphenous Vein Endothelial Cells: Assessment of Their Reproductive Capacity for Use in Endothelial Seeding of Vascular Prostheses 

      Watkins, Michael Thomas; Sharefkin, John B.; Zajtchuk, Rostik; Maciag, Tomas M.; D'Amore, Patricia Ann; Ryan, Una S.; Van Wart, Harold; Rich, Norman M. (Elsevier, 1984)

    • Arterial versus venous endothelial cells 

      dela Paz, Nathaniel G.; D'Amore, Patricia Ann (Springer Nature, 2008)
      Vascular endothelial cells (ECs) form the inner lining of all blood vessels from the largest artery and veins, viz., the aorta and venae cavae, respectively, to the capillaries that connect the arterial and venous systems. ...

    • Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms 

      Stalmans, Ingeborg; Ng, Yin-Shan; Rohan, Richard; Fruttiger, Marcus; Bouché, Ann; Yuce, Ali; Fujisawa, Hajime; Hermans, Bart; Shani, Moshe; Jansen, Sandra; Hicklin, Dan; Anderson, David J.; Gardiner, Tom; Hammes, Hans-Peter; Moons, Lieve; Dewerchin, Mieke; Collen, Désiré; Carmeliet, Peter; D'Amore, Patricia Ann (American Society for Clinical Investigation, 2002)
      The murine VEGF gene is alternatively transcribed to yield the VEGF120, VEGF164, and VEGF188 isoforms, which differ in their potential to bind to heparan sulfate and neuropilin-1 and to stimulate endothelial growth. Here, ...

    • Blood vessel maturation: vascular development comes of age 

      Darland, Diane C.; D'Amore, Patricia Ann (American Society for Clinical Investigation, 1999)

    • Cloning and mRNA expression of vascular endothelial growth factor in ischemic retinas of Macaca fascicularis. 

      Shima, David T.; Gougos, Anne; Miller, Joan Whitten; Tolentino, Michael; Robinson, Gerald; Adamis, Anthony Peter; D'Amore, Patricia Ann (2018-04-25)
      PURPOSE: To identify and isolate cDNAs for the alternatively spliced vascular endothelial growth factor (VEGF) mRNAs present in retina and to compare the relative levels of the splice variants and localization of VEGF mRNA ...

    • The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of Cells 

      Duan, Yajian; Ma, Gaoen; Huang, Xionggao; D'Amore, Patricia Ann; Zhang, Feng; Lei, Hetian (American Society for Biochemistry & Molecular Biology (ASBMB), 2016)
      The 309G allele of single nucleotide polymorphisms (SNPs) in the mouse double minute (MDM2) promoter locus is associated with a higher risk of cancer and proliferative vitreoretinopathy (PVR), but as to whether this SNP ...

    • Comparison of normal and tumorigenic endothelial cells: differences in thrombospondin production and responses to transforming growth factor-beta 

      RayChaudhury, Amlan; Frazier, William A.; D'Amore, Patricia Ann (1994)
      Cultured endothelial cells constitutively synthesize significant levels of thrombospondin, an extracellular matrix-associated protein with reported anti-anti-angiogenic properties. However, two murine endothelial cell ...

    • Contextual role for angiopoietins and TGFbeta1 in blood vessel stabilization 

      Ramsauer, Markus; D'Amore, Patricia Ann (The Company of Biologists, 2007)
      We used a 3D in-vitro model of angiogenesis to investigate the effects of different growth factors on vessel formation and stabilization in vitro. Vascular endothelial growth factor (VEGF) was the only factor that induced ...

    • Coordinated Vascular Endothelial Growth Factor Expression and Signaling During Skeletal Myogenic Differentiation 

      Bryan, Brad A.; Walshe, T. E.; Mitchell, Dianne C.; Havumaki, Josh S.; Saint-Geniez, Magali; Maharaj, Arindel S; Maldonado, Angel E.; D'Amore, Patricia Ann (American Society for Cell Biology (ASCB), 2007)
      Angiogenesis is largely controlled by hypoxia-driven transcriptional up-regulation and secretion of vascular endothelial growth factor (VEGF) and its binding to the endothelial cell tyrosine receptor kinases, VEGFR1 and ...

    • Demonstration of vasoproliferative activity from mammalian retina 

      Glaser, Bert M.; D'Amore, Patricia Ann; Michels, Ronald G.; Patz, Arnall; Fenselau, Allan (Rockefeller University Press, 1980)
      Vasoproliferative activity has been demonstrated in extracts of retinas from human, bovine, and feline sources. These retinal extracts are capable of stimulating (a) proliferation and thymidine uptake of bovine vascular ...

    • Development and pathology of the hyaloid, choroidal and retinal vasculature 

      Saint-Geniez, Magali; D'Amore, Patricia Ann (UPV/EHU Press, 2004)
      During embryogenesis, the development and differentiation of the eye requires the concomitant formation of the neural/glial elements along with a dense vascular network. The adult neural retina is supported by two distinct ...

    • Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors 

      Saint-Geniez, Magali; Maharaj, Arindel S. R.; Walshe, Tony E.; Tucker, Budd A.; Sekiyama, Eiichi; Kurihara, Tomoki; Darland, Diane C.; Young, Michael J.; D'Amore, Patricia Ann (Public Library of Science (PLoS), 2008)
      Background Vascular endothelial growth factor (VEGF) is well known for its role in normal and pathologic neovascularization. However, a growing body of evidence indicates that VEGF also acts on non-vascular cells, both ...

    • Endomucin prevents leukocyte–endothelial cell adhesion and has a critical role under resting and inflammatory conditions 

      Zahr, Alisar; Alcaide, Pilar; Yang, Jinling; Jones, Alexander; Gregory, Meredith; dela Paz, Nathaniel G.; Patel-Hett, Sunita; Nevers, Tania; Koirala, Adarsha; Luscinskas, Francis W.; Saint-Geniez, Magali; Ksander, Bruce; D'Amore, Patricia A.; Argüeso, Pablo (Nature Publishing Group, 2016)
      Endomucin is a membrane-bound glycoprotein expressed luminally by endothelial cells that line postcapillary venules, a primary site of leukocyte recruitment during inflammation. Here we show that endomucin abrogation on ...

    • Endothelial cell mitogens derived from retina and hypothalamus: biochemical and biological similarities 

      D'Amore, Patricia Ann; Klagsbrun, Michael (Rockefeller University Press, 1984)
      Bovine retina and hypothalamus contain anionic endothelial cell mitogens that display unusual affinities for the negatively charged glycosaminoglycan heparin. Both growth factor activities are acidic polypeptides (pl's of ...

    • Epoxyeicosanoids Promote Organ and Tissue Regeneration 

      Panigrahy, Dipak; Kalish, Brian T.; Huang, Sui; Bielenberg, Diane; Le, Hau D.; Yang, Jun; Edin, Matthew L.; Lee, Craig R.; Benny, Ofra; Mudge, Dayna K.; Butterfield, Catherine E.; Mammoto, Akiko; Mammoto, Tadanori; Inceoglu, Bora; Jenkins, Roger L.; Simpson, Mary A.; Akino, Tomoshige; Lih, Fred B.; Tomer, Kenneth B.; Ingber, Donald; Hammock, Bruce D.; Falck, John R.; Manthati, Vijaya L.; Kaipainen, Arja; D'Amore, Patricia; Puder, Mark; Zeldin, Darryl C.; Kieran, Mark W. (National Academy of Sciences, 2013-07-29)
      Epoxyeicosatrienoic acids (EETs), lipid mediators produced by cytochrome P450 epoxygenases, regulate inflammation, angiogenesis, and vascular tone. Despite pleiotropic effects on cells, the role of these epoxyeicosanoids ...

    • Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice 

      Panigrahy, Dipak; Edin, Matthew L.; Lee, Craig R.; Huang, Sui; Bielenberg, Diane; Butterfield, Catherine E.; Barnés, Carmen M.; Mammoto, Akiko; Mammoto, Tadanori; Luria, Ayala; Benny, Ofra; Chaponis, Deviney M.; Dudley, Andrew C.; Greene, Emily R.; Vergilio, Jo-Anne; Pietramaggiori, Giorgio; Scherer-Pietramaggiori, Sandra S.; Short, Sarah M.; Seth, Meetu; Lih, Fred B.; Tomer, Kenneth B.; Yang, Jun; Schwendener, Reto A.; Hammock, Bruce D.; Falck, John R.; Manthati, Vijaya L.; Ingber, Donald Elliot; Kaipainen, Arja; D'Amore, Patricia Ann; Kieran, Mark W.; Zeldin, Darryl C. (American Society for Clinical Investigation, 2012)
      Epoxyeicosatrienoic acids (EETs) are small molecules produced by cytochrome P450 epoxygenases. They are lipid mediators that act as autocrine or paracrine factors to regulate inflammation and vascular tone. As a result, ...

    • Expression and Role of VEGF in the Adult Retinal Pigment Epithelium 

      Ford, Knatokie M.; Saint-Geniez, Magali; Walshe, Tony; Zahr, Alisar; D'Amore, Patricia Ann (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      Purpose.: Despite a lack of active angiogenesis, VEGF is expressed in nearly every adult tissue, and recent evidence suggests that VEGF may serve as a survival factor for both vascular and nonvascular tissues. VEGF blockade ...

    • Expression and Role of VEGF-A in the Ciliary Body 

      Ford, Knatokie M.; Saint-Geniez, Magali; Walshe, Tony E.; D'Amore, Patricia Ann (Association for Research in Vision and Ophthalmology (ARVO), 2012)
      Purpose.: The role of VEGF-A in the normal ciliary body is largely unexplored. The ciliary body is similar in many respects to the choroid plexus of the brain, and we demonstrated previously the importance of VEGF-A in ...

    • Expression of fibroblast growth factor by F9 teratocarcinoma cells as a function of differentiation 

      Braunhut, Susan J.; Gudas, Lorraine J.; Kurokawa, Tsutomu; Sasse, Joachim; D'Amore, Patricia Ann (Rockefeller University Press, 2018-04-25)
      Growth factors may be required at sites of mechanical injury and normal wear and tear in vivo, suggesting that the direct action of mechanical forces on cells could lead to growth factor release. Scraping of cells from the ...