Now showing items 1-5 of 5

    • The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine 

      Vassy, Jason L; Lautenbach, Denise M; McLaughlin, Heather M; Kong, Sek Won; Christensen, Kurt D; Krier, Joel; Kohane, Isaac S; Feuerman, Lindsay Z; Blumenthal-Barby, Jennifer; Roberts, J Scott; Lehmann, Lisa Soleymani; Ho, Carolyn Y; Ubel, Peter A; MacRae, Calum A; Seidman, Christine E; Murray, Michael F; McGuire, Amy L; Rehm, Heidi L; Green, Robert C (BioMed Central, 2014)
      Background: Whole genome sequencing (WGS) is already being used in certain clinical and research settings, but its impact on patient well-being, health-care utilization, and clinical decision-making remains largely unstudied. ...
    • NIH working group report—using genomic information to guide weight management: From universal to precision treatment 

      Bray, Molly S; Loos, Ruth JF; McCaffery, Jeanne M; Ling, Charlotte; Franks, Paul W; Weinstock, George M; Snyder, Michael P; Vassy, Jason L; Agurs-Collins, Tanya (John Wiley & Sons, Ltd, 2015)
      Objective: Precision medicine utilizes genomic and other data to optimize and personalize treatment. Although more than 2,500 genetic tests are currently available, largely for extreme and/or rare phenotypes, the question ...
    • Personalized Genetic Risk Counseling to Motivate Diabetes Prevention: A randomized trial 

      Grant, Richard W.; O’Brien, Kelsey E.; Waxler, Jessica L.; Vassy, Jason L.; Delahanty, Linda M.; Bissett, Laurie G.; Green, Robert C.; Stember, Katherine G.; Guiducci, Candace; Park, Elyse R.; Florez, Jose C.; Meigs, James B. (American Diabetes Association, 2013)
      OBJECTIVE To examine whether diabetes genetic risk testing and counseling can improve diabetes prevention behaviors. RESEARCH DESIGN AND METHODS We conducted a randomized trial of diabetes genetic risk counseling among ...
    • Race-Ethnic Differences in the Association of Genetic Loci with HbA1c levels and Mortality in U.S. Adults: The Third National Health and Nutrition Examination Survey (NHANES III) 

      Grimsby, Jonna L; Porneala, Bianca C; Yang, Quanhe; Dupuis, Josée; Liu, Tiebin; Yesupriya, Ajay; Chang, Man-Huei; Ned, Renee M; Dowling, Nicole F; Khoury, Muin J; Vassy, Jason Lyell; Florez, Jose Carlos; Meigs, James Benjamin (BioMed Central, 2012)
      Background: Hemoglobin A1c (HbA1c) levels diagnose diabetes, predict mortality and are associated with ten single nucleotide polymorphisms (SNPs) in white individuals. Genetic associations in other race groups are not ...
    • A systematic approach to the reporting of medically relevant findings from whole genome sequencing 

      McLaughlin, Heather M; Ceyhan-Birsoy, Ozge; Christensen, Kurt D; Kohane, Isaac S; Krier, Joel; Lane, William J; Lautenbach, Denise; Lebo, Matthew S; Machini, Kalotina; MacRae, Calum A; Azzariti, Danielle R; Murray, Michael F; Seidman, Christine E; Vassy, Jason L; Green, Robert C; Rehm, Heidi L (BioMed Central, 2014)
      Background: The MedSeq Project is a randomized clinical trial developing approaches to assess the impact of integrating genome sequencing into clinical medicine. To facilitate the return of results of potential medical ...