Now showing items 1-20 of 26

    • Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia 

      Newman, K D; Dunn, Peter Francis; Owens, J W; Schulick, A H; Virmani, R; Sukhova, Galina K.; Libby, Peter; Dichek, D A (American Society for Clinical Investigation, 1995)
      Adenovirus vectors are capable of high efficiency in vivo arterial gene transfer, and are currently in use as therapeutic agents in animal models of vascular disease. However, despite substantial data on the ability of ...
    • Allergic Lung Inflammation Aggravates Angiotensin II–Induced Abdominal Aortic Aneurysms in Mice 

      Liu, Cong-Lin; Wang, Yi; Liao, Mengyang; Wemmelund, Holger; Ren, Jingyuan; Fernandes, Cleverson; Zhou, Yi; Sukhova, Galina K.; Lindholt, Jes S.; Johnsen, Søren P.; Zhang, Jin-Ying; Cheng, Xiang; Huang, Xiaozhu; Daugherty, Alan; Levy, Bruce David; Libby, Peter; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2015)
    • Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice 

      Liu, Cong-Lin; Wang, Yi; Liao, Mengyang; Santos, Marcela Malheiro; Fernandes, Cleverson; Sukhova, Galina K.; Zhang, Jin-Ying; Cheng, Xiang; Yang, Chongzhe; Huang, Xiaozhu; Levy, Bruce David; Libby, Peter; Wu, Gongxiong; Shi, Guo-Ping (Elsevier BV, 2016)
      Inflammation drives asthma and atherosclerosis. Clinical studies suggest that asthmatic patients have a high risk of atherosclerosis. Yet this hypothesis remains uncertain, given that Th2 imbalance causes asthma whereas ...
    • Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3 

      Qin, Zhexue; Bagley, Jessamyn; Sukhova, Galina K.; Baur, Wendy E.; Park, Ho-Jin; Beasley, Debbie; Libby, Peter; Zhang, Yali; Galper, Jonas B. (Elsevier BV, 2015)
      Abdominal Aortic Aneurysm (AAA) is a major cause of mortality and morbidity in men over 65 years of age. Male apolipoprotein E knockout (ApoE−/−) mice infused with angiotensin II (AngII) develop AAA. Although AngII stimulates ...
    • Asthma Associates With Human Abdominal Aortic Aneurysm and RuptureSignificance 

      Liu, Cong-Lin; Wemmelund, Holger; Wang, Yi; Liao, Mengyang; Lindholt, Jes S.; Johnsen, Søren P.; Vestergaard, Henrik; Fernandes, Cleverson; Sukhova, Galina K.; Cheng, Xiang; Zhang, Jin-Ying; Yang, Chongzhe; Huang, Xiaozhu; Daugherty, Alan; Levy, Bruce David; Libby, Peter; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2016)
      Objective—Both asthma and abdominal aortic aneurysms (AAA) involve inflammation. It remains unknown whether these diseases interact. Approach and Results—Databases analyzed included Danish National Registry of Patients, ...
    • Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice 

      Sun, Jiusong; Sukhova, Galina K.; Zhang, Jie; Chen, Han; Sjoberg, Sara; Libby, Peter; Xia, Mingcan; Xiong, Na; Gelb, Bruce D.; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2011)
      Objective: Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression of CatK in human abdominal aortic aneurysm (AAA) lesions. Whether this protease participates directly ...
    • Cathepsin L Activity Is Essential to Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice 

      Sun, Jiusong; Sukhova, Galina K.; Zhang, Jie; Chen, Han; Sjoberg, S.; Libby, Peter; Xiang, M.; Wang, J.; Peters, C.; Reinheckel, T.; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2011)
      Objective—The development of abdominal aortic aneurysms (AAA) requires extensive aortic wall matrix degradation. Human AAA lesions express high levels of cathepsin L (CatL), one of the most potent mammalian elastases. ...
    • Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells 

      Liu, Jian; Sukhova, Galina K.; Yang, Jin-Tian; Sun, Jiusong; Ma, Likun; Ren, An; Xu, Wei-Hua; Fu, Huanxiang; Dolganov, Gregory M.; Hu, Chengcheng; Libby, Peter; Shi, Guo-Ping (Elsevier BV, 2006)
      The cysteine protease cathepsin L is one of the most potent mammalian elastases and collagenases, widely expressed at basal levels in most tested tissues and cell types, and regulated by pro-inflammatory stimuli. The ...
    • CXCR3 Controls T-Cell Accumulation in Fat Inflammation 

      Rocha, V. Z.; Folco, Eduardo; Ozdemir, Cafer; Sheikine, Y.; Christen, T.; Sukhova, Galina K.; Tang, E. H. C.; Bittencourt, M. S.; Santos, R. D.; Luster, Andrew David; Cohen, David E; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 2014)
      Objective—Obesity associates with increased numbers of inflammatory cells in adipose tissue (AT), including T cells, but the mechanism of T-cell recruitment remains unknown. This study tested the hypothesis that the chemokine ...
    • Cystatin C deficiency in human atherosclerosis and aortic aneurysms 

      Shi, Guo-Ping; Sukhova, Galina K.; Grubb, Anders; Ducharme, Anique; Rhode, Luis H.; Lee, Richard Theodore; Ridker, Paul M.; Libby, Peter; Chapman, Harold A. (American Society for Clinical Investigation, 1999)
      The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves breakdown of the elastic laminae. Elastolytic cysteine proteases, including cathepsins S and K, are overexpressed at sites of arterial elastin ...
    • Deficiency of cathepsin S reduces atherosclerosis in LDL receptor–deficient mice 

      Sukhova, Galina K.; Zhang, Yaou; Pan, Jie-Hong; Wada, Youichiro; Yamamoto, Takashi; Naito, Makoto; Kodama, Tatsuhiko; Tsimikas, Sotirios; Witztum, Joseph L.; Lu, Michael L.; Sakara, Yasuhiko; Chin, Michael T.; Libby, Peter; Shi, Guo-Ping (American Society for Clinical Investigation, 2003)
      Human atherosclerotic lesions overexpress the lysosomal cysteine protease cathepsin S (Cat S), one of the most potent mammalian elastases known. In contrast, atheromata have low levels of the endogenous Cat S inhibitor ...
    • Deletion of EP4 on Bone Marrow-Derived Cells Enhances Inflammation and Angiotensin II-Induced Abdominal Aortic Aneurysm Formation 

      Tang, E. H. C.; Shvartz, E.; Shimizu, K.; Rocha, V. Z.; Zheng, Chunyu; Fukuda, D.; Shi, Guo-Ping; Sukhova, Galina K.; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 2010)
      Objective—To examine whether a lack of prostaglandin E receptor 4 (EP4) on bone marrow–derived cells would increase local inflammation and enhance the formation of abdominal aortic aneurysm (AAA) in vivo. Methods and ...
    • Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells 

      Mach, François; Sauty, Alain; Iarossi, Albert S.; Sukhova, Galina K.; Neote, Kuldeep; Libby, Peter; Luster, Andrew David (American Society for Clinical Investigation, 1999)
      Activated T lymphocytes accumulate early in atheroma formation and persist at sites of lesion growth and rupture, suggesting that they may play an important role in the pathogenesis of atherosclerosis. Moreover, atherosclerotic ...
    • Echocardiography-derived left ventricular end-systolic regional wall stress and matrix remodeling after experimental myocardial infarction 

      Rohde, Luis E; Aikawa, Masanori; Cheng, George Z; Sukhova, Galina K.; Solomon, Scott David; Libby, Peter; Pfeffer, Janice; Pfeffer, Marc Alan; Lee, Richard Theodore (Elsevier BV, 1999)
      OBJECTIVES We tested the hypothesis that regional end-systolic left ventricular (ESLV) wall stress is associated with extracellular matrix remodeling activity after myocardial infarction (MI). BACKGROUND Increased ...
    • Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells 

      Sukhova, Galina K.; Shi, Guo-Ping; Simon, D I; Chapman, H A; Libby, Peter (American Society for Clinical Investigation, 1998)
      Formation of the atherosclerotic intima must involve altered metabolism of the elastin-rich arterial extracellular matrix. Proteases potentially involved in these processes remain unclear. This study examined the expression ...
    • Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in MiceNovelty and Significance 

      Franck, Grégory; Mawson, Thomas L.; Sausen, Grasiele; Salinas, Manuel; Masson, Gustavo Santos; Cole, Andrew James; Beltrami-Moreira, Marina; Chatzizisis, Yiannis; Quillard, Thibault; Tesmenitsky, Yevgenia; Shvartz, Eugenia; Sukhova, Galina K.; Swirski, Filip K.; Nahrendorf, Matthias; Aikawa, Elena; Croce, Kevin James; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 2017)
    • IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms 

      Wang, Jing; Lindholt, Jes S; Sukhova, Galina K; Shi, Michael A; Xia, Mingcan; Chen, Han; Xiang, Meixiang; He, Aina; Wang, Yi; Xiong, Na; Libby, Peter; Wang, Jian-An; Shi, Guo-Ping (BlackWell Publishing Ltd, 2014)
      Immunoglobulin E (IgE) activates mast cells (MCs). It remains unknown whether IgE also activates other inflammatory cells, and contributes to the pathogenesis of abdominal aortic aneurysms (AAAs). This study demonstrates ...
    • Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques 

      Galis, Z S; Sukhova, Galina K.; Lark, M W; Libby, Peter (American Society for Clinical Investigation, 1994)
      Dysregulated extracellular matrix (ECM) metabolism may contribute to vascular remodeling during the development and complication of human atherosclerotic lesions. We investigated the expression of matrix metalloproteinases ...
    • Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter 

      Wang, Jing; Sun, Chongxiu; Gerdes, Norbert; Liu, Conglin; Liao, Mengyang; Liu, Jianping; Shi, Michael A; He, Aina; Zhou, Yi; Sukhova, Galina K.; Chen, Huimei; Cheng, Xian; Kuzuya, Masafumi; Murohara, Toyoaki; Zhang, Jie; Cheng, Xiang; Jiang, Mengmeng; Shull, Gary E; Rogers, Shaunessy; Yang, Chao-Ling; Ke, Qiang; Jelen, Sabina; Bindels, René; Ellison, David H; Jarolim, Petr; Libby, Peter; Shi, Guo-Ping (Nature Publishing Group, 2015)
      Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms1, 2. Interruption of IL18 action reduces atherosclerosis in mice3, 4. Here, we show that absence of the IL18 receptor (IL18r) does not ...
    • Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions 

      Tang, E. H. C.; Shimizu, K.; Christen, T.; Rocha, V. Z.; Shvartz, E.; Tesmenitsky, Y.; Sukhova, Galina K.; Shi, Guo-Ping; Libby, Peter (Oxford University Press (OUP), 2010)
      Aim: Prostaglandin E2, by ligation of its receptor EP4, suppresses the production of inflammatory cytokines and chemokines in macrophages in vitro. Thus, activation of EP4 may constitute an endogenous anti-inflammatory ...