Browsing by Author "Mannstadt, Beate"
Now showing items 1-9 of 9
-
Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice
Zhou, Jingming; Chen, Qian; Lanske, Beate; Fleming, Braden C; Terek, Richard; Wei, Xiaochun; Zhang, Ge; Wang, Shaowei; Li, Kai; Wei, Lei (BioMed Central, 2014)Introduction: Previous observations implicate Indian hedgehog (Ihh) signaling in osteoarthritis (OA) development because it regulates chondrocyte hypertrophy and matrix metallopeptidase 13 (MMP-13) expression. However, ... -
FGF23 Deficiency Leads to Mixed Hearing Loss and Middle Ear Malformation in Mice
Lysaght, Andrew C.; Yuan, Quan; Fan, Yi; Kalwani, Neil; Caruso, Paul; Cunnane, MaryBeth; Lanske, Beate; Stanković, Konstantina M. (Public Library of Science, 2014)Fibroblast growth factor 23 (FGF23) is a circulating hormone important in phosphate homeostasis. Abnormal serum levels of FGF23 result in systemic pathologies in humans and mice, including renal phosphate wasting diseases ... -
FGF23 neutralization improves bone quality and osseointegration of titanium implants in chronic kidney disease mice
Sun, Ningyuan; Guo, Yuchen; Liu, Weiqing; Densmore, Michael; Shalhoub, Victoria; Erben, Reinhold G.; Ye, Ling; Lanske, Beate; Yuan, Quan (Nature Publishing Group, 2015)Chronic kidney disease (CKD) is a worldwide health problem. Serum levels of FGF23, a phosphaturic hormone, increase at the earliest stages of CKD, and have been found to be independently associated with the mortality and ... -
Fibroblast Growth Factor–23 and Cardiac Structure and Function
Agarwal, Isha; Ide, Noriko; Ix, Joachim H.; Kestenbaum, Bryan; Lanske, Beate; Schiller, Nelson B.; Whooley, Mary A.; Mukamal, Kenneth J. (Blackwell Publishing Ltd, 2014)Background: Fibroblast growth factor–23 (FGF‐23) is a phosphaturic factor previously associated with left ventricular hypertrophy and systolic dysfunction among individuals with chronic kidney disease. Whether FGF‐23 acts ... -
Genetic evidence of serum phosphate-independent functions of FGF-23 on bone
Sitara, Despina; Kim, Somi; Razzaque, Mohammed Shawkat; Bergwitz, Clemens; Taguchi, Takashi; Schüler, Christiane; Erben, Reinhold G.; Lanske, Beate Klara Maria (Public Library of Science, 2008)Maintenance of physiologic phosphate balance is of crucial biological importance, as it is fundamental to cellular function, energy metabolism, and skeletal mineralization. Fibroblast growth factor-23 (FGF-23) is a master ... -
Molecular interactions of FGF23 and PTH in phosphate regulation
Lanske, Beate; Razzaque, Mohammed S. (2014)Bone-derived fibroblast growth factor-23 (FGF23) plays an important role in systemic phosphate turnover. Increased FGF23 activity results in hypophosphatemic, while reduced activity is linked to hyperphosphatemic disorders. ... -
Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion
Olauson, Hannes; Lindberg, Karolina; Amin, Risul; Sato, Tadatoshi; Jia, Ting; Goetz, Regina; Mohammadi, Moosa; Andersson, Göran; Lanske, Beate; Larsson, Tobias E. (Public Library of Science, 2013)Klotho acts as a co-receptor for and dictates tissue specificity of circulating FGF23. FGF23 inhibits PTH secretion, and reduced Klotho abundance is considered a pathogenic factor in renal secondary hyperparathyroidism. ... -
VEGF-Dependent Mechanisms Controlling Osteoblast Differentiation and Bone Formation During Bone Repair
Hu, Kai (2015-05-05)Osteoblast-derived vascular endothelial growth factor (VEGF) is important for bone development and postnatal bone homeostasis. Several studies have demonstrated that VEGF affects bone repair and regeneration; however, the ... -
Vitamin D Supplementation Enhances the Fixation of Titanium Implants in Chronic Kidney Disease Mice
Liu, Weiqing; Zhang, Shiwen; Zhao, Dan; Zou, Huawei; Sun, Ningyuan; Liang, Xing; Dard, Michel; Lanske, Beate; Yuan, Quan (Public Library of Science, 2014)Vitamin D (Vit D) deficiency is a common condition in chronic kidney disease (CKD) patients that negatively affects bone regeneration and fracture healing. Previous study has shown that timely healing of titanium implants ...