Browsing by Author "Brusic, Vladimir"
Now showing items 1-7 of 7
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Conservation Analysis of Dengue Virus T-cell Epitope-Based Vaccine Candidates Using Peptide Block Entropy
Olsen, Lars Rønn; Zhang, Guang Lan; Keskin, Derin Benerci; Reinherz, Ellis Leonard; Brusic, Vladimir (Frontiers Research Foundation, 2011)Broad coverage of the pathogen population is particularly important when designing CD8+ T-cell epitope vaccines against viral pathogens. Traditional approaches are based on combinations of highly conserved T-cell epitopes. ... -
Direct Identification of an HPV-16 Tumor Antigen from Cervical Cancer Biopsy Specimens
Keskin, Derin Benerci; Reinhold, Bruce B.; Lee, Sun Young; Zhang, Guanglan; Lank, Simon; O’Connor, David H.; Berkowitz, Ross Stuart; Brusic, Vladimir; Kim, Seung Jo; Reinherz, Ellis Leonard (Frontiers Research Foundation, 2011)Persistent infection with high-risk human papilloma viruses (HPV) is the worldwide cause of many cancers, including cervical, anal, vulval, vaginal, penile, and oropharyngeal. Since T cells naturally eliminate the majority ... -
Evaluation of MHC Class I Peptide Binding Prediction Servers: Applications for Vaccine Research
Lin, Hong Huang; Ray, Surajit; Tongchusak, Songsak; Reinherz, Ellis Leonard; Brusic, Vladimir (BioMed Central, 2008)Background: Protein antigens and their specific epitopes are formulation targets for epitope-based vaccines. A number of prediction servers are available for identification of peptides that bind major histocompatibility ... -
HPVdb: a data mining system for knowledge discovery in human papillomavirus with applications in T cell immunology and vaccinology
Zhang, Guang Lan; Riemer, Angelika B.; Keskin, Derin B.; Chitkushev, Lou; Reinherz, Ellis L.; Brusic, Vladimir (Oxford University Press, 2014)High-risk human papillomaviruses (HPVs) are the causes of many cancers, including cervical, anal, vulvar, vaginal, penile and oropharyngeal. To facilitate diagnosis, prognosis and characterization of these cancers, it is ... -
Large-Scale Analysis of B-Cell Epitopes on Influenza Virus Hemagglutinin – Implications for Cross-Reactivity of Neutralizing Antibodies
Sun, Jing; Kudahl, Ulrich J.; Simon, Christian; Cao, Zhiwei; Reinherz, Ellis L.; Brusic, Vladimir (Frontiers Media S.A., 2014)Influenza viruses continue to cause substantial morbidity and mortality worldwide. Fast gene mutation on surface proteins of influenza virus result in increasing resistance to current vaccines and available antiviral drugs. ... -
Predicting Peptides Binding to MHC Class II Molecules Using Multi-objective Evolutionary Algorithms
Rajapakse, Menaka; Schmidt, Bertil; Feng, Lin; Brusic, Vladimir (BioMed Central, 2007)Background: Peptides binding to Major Histocompatibility Complex (MHC) class II molecules are crucial for initiation and regulation of immune responses. Predicting peptides that bind to a specific MHC molecule plays an ... -
Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing
Lank, Simon M; Golbach, Brittney A; Creager, Hannah M; Wiseman, Roger W; Keskin, Derin Benerci; Reinherz, Ellis Leonard; Brusic, Vladimir; O’Connor, David H (BioMed Central, 2012)Background: High-resolution HLA genotyping is a critical diagnostic and research assay. Current methods rarely achieve unambiguous high-resolution typing without making population-specific frequency inferences due to a ...