Now showing items 1-5 of 5

    • An Antimicrobial Peptidomimetic Induces Mucorales Cell Death through Mitochondria-Mediated Apoptosis 

      Barbu, E. Magda; Shirazi, Fazal; McGrath, Danielle M.; Albert, Nathaniel; Sidman, Richard L.; Pasqualini, Renata; Arap, Wadih; Kontoyiannis, Dimitrios P. (Public Library of Science, 2013)
      The incidence of mucormycosis has dramatically increased in immunocompromised patients. Moreover, the array of cellular targets whose inhibition results in fungal cell death is rather limited. Mitochondria have been ...
    • Bone marrow-derived CD13+ cells sustain tumor progression: A potential non-malignant target for anticancer therapy 

      Dondossola, Eleonora; Corti, Angelo; Sidman, Richard L; Arap, Wadih; Pasqualini, Renata (Landes Bioscience, 2014)
      Non-malignant cells found within neoplastic lesions express alanyl (membrane) aminopeptidase (ANPEP, best known as CD13), and CD13-null mice exhibit limited tumor growth and angiogenesis. We have recently demonstrated that ...
    • Brain endothelial cell‐targeted gene therapy of neurovascular disorders 

      Marchiò, Serena; Sidman, Richard L; Arap, Wadih; Pasqualini, Renata (John Wiley and Sons Inc., 2016)
      Neurovascular disorders are difficult to treat due to the blood–brain barrier (BBB), which prevents delivery of most drugs from the blood into the brain. Gene therapy can potentially overcome this barrier, but classical ...
    • Combinatorial Targeting and Discovery of Ligand-Receptors in Organelles of Mammalian Cells 

      Rangel, Roberto; Guzman-Rojas, Liliana; le Roux, Lucia G.; Staquicini, Fernanda I.; Hosoya, Hitomi; Barbu, E. Magda; Ozawa, Michael G.; Nie, Jing; Langley, Robert R.; Sage, E. Helene; Koivunen, Erkki; Gelovani, Juri G.; Lobb, Roy R.; Pasqualini, Renata; Arap, Wadih; Sidman, Richard Leon; Dunner, Kenneth, Jr. (Nature Pub. Group, 2012)
      Phage display screening allows the study of functional protein–protein interactions at the cell surface, but investigating intracellular organelles remains a challenge. Here we introduce internalizing-phage libraries to ...
    • Functional Multipotency of Stem Cells: A Conceptual Review of Neurotrophic Factor-Based Evidence and Its Role in Translational Research 

      Kabatas, Serdar; Wakeman, Dustin R; Wang, Junmei; Snyder, Evan Y; Teng, Yang D.; Yu, Dou; Ropper, Alexander Eli; Li, Jianxue; Sullivan, Maryrose P.; Redmond, D. Eugene; Langer, Robert S.; Sidman, Richard Leon (Bentham Science Publishers, 2011)
      We here propose an updated concept of stem cells (SCs), with an emphasis on neural stem cells (NSCs). The conventional view, which has touched principally on the essential property of lineage multipotency (e.g., the ability ...