Now showing items 1-5 of 5

    • Emotional enhancement of memory: how norepinephrine enables synaptic plasticity 

      Tully, Keith Leo; Bolshakov, Vadim (BioMed Central, 2010)
      Changes in synaptic strength are believed to underlie learning and memory. We explore the idea that norepinephrine is an essential modulator of memory through its ability to regulate synaptic mechanisms. Emotional arousal ...
    • Identity of Endogenous NMDAR Glycine Site Agonist in Amygdala Is Determined by Synaptic Activity Level 

      Li, Yan; Sacchi, Silvia; Pollegioni, Loredano; Basu, Alo C.; Coyle, Joseph T.; Bolshakov, Vadim Y. (2013)
      Mechanisms of NMDA receptor-dependent synaptic plasticity contribute to the acquisition and retention of conditioned fear memory. However, synaptic rules which may determine the extent of NMDA receptor activation in the ...
    • Kainate Receptor-Mediated Modulation of Hippocampal Fast Spiking Interneurons in a Rat Model of Schizophrenia 

      Gisabella, Barbara B.; Bolshakov, Vadim; Benes, Francine Mary (Public Library of Science, 2012)
      Kainate receptor (KAR) subunits are believed to be involved in abnormal GABAergic neurotransmission in the hippocampus (HIPP) in schizophrenia (SZ) and bipolar disorder. Postmortem studies have shown changes in the expression ...
    • Modulation of anxiety and fear via distinct intrahippocampal circuits 

      Engin, Elif; Smith, Kiersten S; Gao, Yudong; Nagy, David; Foster, Rachel A; Tsvetkov, Evgeny; Keist, Ruth; Crestani, Florence; Fritschy, Jean-Marc; Bolshakov, Vadim Y; Hajos, Mihaly; Heldt, Scott A; Rudolph, Uwe (eLife Sciences Publications, Ltd, 2016)
      Recent findings indicate a high level of specialization at the level of microcircuits and cell populations within brain structures with regards to the control of fear and anxiety. The hippocampus, however, has been treated ...
    • Recent advances in basic neurosciences and brain disease: from synapses to behavior 

      Bi, Guo-Qiang; Bu, Guojun; Chen, Zhou-Feng; Collingridge, Graham L; Cooper, Robin L; Coorssen, Jens R; El-Husseini, Alaa; Galhardo, Vasco; Gan, Wen-Biao; Gu, Jianguo; Inoue, Kazuhide; Isaac, John; Iwata, Koichi; Jia, Zhengping; Kaang, Bong-Kiun; Kawamata, Mikito; Kida, Satoshi; Klann, Eric; Kohno, Tatsuro; Li, Xiao-Jiang; Nader, Karim; Oh, Uhtaek; Ren, Ke; Roder, John C; Salter, Michael W; Song, Weihong; Sugita, Shuzo; Tang, Shao-Jun; Tao, Yuanxiang; Woo, Newton; Woodin, Melanie A; Yoshimura, Megumu; Xu, Zao C; Zhen, Mei; Zhuo, Min; Bolshakov, Vadim; Cahill, Catherine M.; Li, Min; McDonald, John F.; Nguyen, Peter V.; Wang, Yu Tian; Yan, Zhen; Xu, Ming; Zhang, Xia (BioMed Central, 2006)
      Understanding basic neuronal mechanisms hold the hope for future treatment of brain disease. The 1st international conference on synapse, memory, drug addiction and pain was held in beautiful downtown Toronto, Canada on ...