Now showing items 1-6 of 6

    • Allele-Specific Methylation Occurs at Genetic Variants Associated with Complex Disease 

      Hutchinson, John N.; Raj, Towfique; Fagerness, Jes; Stahl, Eli; Viloria, Fernando T.; Gimelbrant, Alexander; Seddon, Johanna; Daly, Mark; Chess, Andrew; Plenge, Robert (Public Library of Science, 2014)
      We hypothesize that the phenomenon of allele-specific methylation (ASM) may underlie the phenotypic effects of multiple variants identified by Genome-Wide Association studies (GWAS). We evaluate ASM in a human population ...
    • Autosomal Monoallelic Expression in the Mouse 

      Zwemer, Lillian M; Zak, Alexander; Thompson, Benjamin R; Kirby, Andrew; Daly, Mark Joseph; Chess, Andrew; Gimelbrant, Alexander (BioMed Central, 2012)
      Background: Random monoallelic expression defines an unusual class of genes displaying random choice for expression between the maternal and paternal alleles. Once established, the allele-specific expression pattern is ...
    • Chromatin Signature Identifies Monoallelic Gene Expression Across Mammalian Cell Types 

      Nag, Anwesha; Vigneau, Sébastien; Savova, Virginia; Zwemer, Lillian M.; Gimelbrant, Alexander A. (Genetics Society of America, 2015)
      Monoallelic expression of autosomal genes (MAE) is a widespread epigenetic phenomenon which is poorly understood, due in part to current limitations of genome-wide approaches for assessing it. Recently, we reported that a ...
    • Chromatin signature of widespread monoallelic expression 

      Nag, Anwesha; Savova, Virginia; Fung, Ho-Lim; Miron, Alexander; Yuan, Guo-Cheng; Zhang, Kun; Gimelbrant, Alexander A (eLife Sciences Publications, Ltd, 2013)
      In mammals, numerous autosomal genes are subject to mitotically stable monoallelic expression (MAE), including genes that play critical roles in a variety of human diseases. Due to challenges posed by the clonal nature of ...
    • dbMAE: the database of autosomal monoallelic expression 

      Savova, Virginia; Patsenker, Jon; Vigneau, Sébastien; Gimelbrant, Alexander A. (Oxford University Press, 2016)
      Recently, data on ‘random’ autosomal monoallelic expression has become available for the entire genome in multiple human and mouse tissues and cell types, creating a need for better access and dissemination. The database ...
    • Genes with monoallelic expression contribute disproportionately to genetic diversity in humans 

      Savova, Virginia; Chun, Sung; Sohail, Mashaal; McCole, Ruth B.; Witwicki, Robert; Gai, Lisa; Lenz, Tobias L.; Wu, C.-ting; Sunyaev, Shamil R.; Gimelbrant, Alexander A. (2016)
      An unexpectedly large number of human autosomal genes are subject to monoallelic expression (MAE). Our analysis of 4,227 such genes reveals surprisingly high genetic variation across human populations. This increased ...