Now showing items 1-5 of 5

    • Developmental Decrease of Neuronal Chloride Concentration Is Independent of Trauma in Thalamocortical Brain Slices 

      Glykys, Joseph; Staley, Kevin J. (Public Library of Science, 2016)
      The intraneuronal chloride concentration ([Cl-]i) is paramount for determining the polarity of signaling at GABAA synapses in the central nervous system. Sectioning hippocampal brain slices increases [Cl-]i in the superficial ...
    • Diazepam effect during early neonatal development correlates with neuronal Cl− 

      Glykys, Joseph; Staley, Kevin J. (John Wiley and Sons Inc., 2015)
      Abstract Objective: Although benzodiazepines and other GABAA receptors allosteric modulators are used to treat neonatal seizures, their efficacy may derive from actions on subcortical structures. Side effects of benzodiazepines ...
    • Neuroprotective levels of IGF-1 exacerbate epileptogenesis after brain injury 

      Song, Yu; Pimentel, Corrin; Walters, Katherine; Boller, Lauren; Ghiasvand, Shabnam; Liu, Jing; Staley, Kevin J.; Berdichevsky, Yevgeny (Nature Publishing Group, 2016)
      Exogenous Insulin-Like Growth Factor-1 (IGF-1) is neuroprotective in animal models of brain injury, and has been considered as a potential therapeutic. Akt-mTOR and MAPK are downstream targets of IGF-1 signaling that are ...
    • Staged anticonvulsant screening for chronic epilepsy 

      Berdichevsky, Yevgeny; Saponjian, Yero; Park, Kyung‐Il; Roach, Bonnie; Pouliot, Wendy; Lu, Kimberly; Swiercz, Waldemar; Dudek, F. Edward; Staley, Kevin J. (John Wiley and Sons Inc., 2016)
      Abstract Objective: Current anticonvulsant screening programs are based on seizures evoked in normal animals. One‐third of epileptic patients do not respond to the anticonvulsants discovered with these models. We evaluated ...
    • What Elements of the Inflammatory System Are Necessary for Epileptogenesis In Vitro?1,2 

      Park, Kyung-Il; Dzhala, Volodymyr; Saponjian, Yero; Staley, Kevin J. (Society for Neuroscience, 2015)
      Abstract Epileptogenesis in vivo can be altered by manipulation of molecules such as cytokines and complement that subserve intercellular signaling in both the inflammatory and central nervous systems. Because of the dual ...