Browsing by Author "Zhong, Jiateng"
Now showing items 1-3 of 3
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DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction
Wang, Zhiwei; Inuzuka, Hiroyuki; Zhong, Jiateng; Fukushima, Hidefumi; Wan, Lixin; Liu, Pengda; Wei, Wenyi (Impact Journals LLC, 2012)The Mdm2 oncoprotein promotes p53 ubiquitination and destruction. Yet, exact molecular mechanisms of Mdm2 destruction itself, under DNA damaging conditions, remain unclear. Recently, we identified SCFβ-TRCP as a novel E3 ... -
Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2
Wang, Zhiwei; Inuzuka, Hiroyuki; Zhong, Jiateng; Liu, Pengda; Sarkar, Fazlul H.; Sun, Yi; Wei, Wenyi (Impact Journals LLC, 2012)The Skp2 (S-phase kinase associated protein 2) oncoprotein is often highly expressed in various types of human cancers. However, the mechanistic basis of its oncogenic function, as well as the upstream regulatory pathway(s) ... -
SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration
Zhong, Jiateng; Shaik, Shavali; Wan, Lixin; Tron, Adriana E.; Wang, Zhiwei; Sun, Liankun; Inuzuka, Hiroyuki; Wei, Wenyi (Impact Journals LLC, 2013)Metastasis suppressor 1 (MTSS1) is an important tumor suppressor protein, and loss of MTSS1 expression has been observed in several types of human cancers. Importantly, decreased MTSS1 expression is associated with more ...