Now showing items 1-20 of 25

    • Adiponectin Deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling 

      Medoff, Benjamin D.; Okamoto, Yoshihisa; Leyton, Patricio; Weng, Meiqian; Sandall, Barry P.; Raher, Michael J.; Kihara, Shinji; Bloch, Kenneth Daniel; Libby, Peter; Luster, Andrew David (American Thoracic Society, 2009)
      Obesity is associated with an increased incidence and severity of asthma, as well as other lung disorders, such as pulmonary hypertension. Adiponectin (APN), an antiinflammatory adipocytokine, circulates at lower levels ...
    • Allergic Non-Asthmatic Adults Have Regional Pulmonary Responses to Segmental Allergen Challenge 

      Kelly, Vanessa J.; Winkler, Tilo; Venegas, Jose G.; Kone, Mamary; Hamilos, Daniel L.; Afshar, Roshi; Cho, Josalyn L.; Luster, Andrew D.; Medoff, Benjamin D.; Harris, R. Scott (Public Library of Science, 2015)
      Background: Allergic non-asthmatic (ANA) adults experience upper airway symptoms of allergic disease such as rhinorrhea, congestion and sneezing without symptoms of asthma. The aim of this study was to utilize PET-CT ...
    • Borrelia burgdorferi Stimulation of Chemokine Secretion by Cells of Monocyte Lineage in Patients with Lyme Arthritis 

      Shin, Junghee J; Strle, Klemen; Glickstein, Lisa J; Luster, Andrew David; Steere, Allen Caruthers (BioMed Central, 2010)
      Introduction: Joint fluid in patients with Lyme arthritis often contains high levels of CCL4 and CCL2, which are chemoattractants for monocytes and some T cells, and CXCL9 and CXCL10, which are chemoattractants for CD4+ ...
    • CCR5 Is Essential for NK Cell Trafficking and Host Survival following Toxoplasma gondii Infection 

      Khan, Imtiaz A; Thomas, Seddon Y; Moretto, Magali M; Lee, Frederick S; Islam, Sabina A.; Combe, Crescent; Schwartzman, Joseph D; Luster, Andrew David (Public Library of Science, 2006)
      The host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate ...
    • Crystalline silica-induced leukotrieneB4-dependent inflammation promotes lung tumor growth 

      Satpathy, Shuchismita R.; Jala, Venkatakrishna R.; Bodduluri, Sobha R.; Krishnan, Elangovan; Hegde, Bindu; Hoyle, Gary; Fraig, Mostafa; Luster, Andrew D.; Haribabu, Bodduluri (2015)
      Chronic exposure to crystalline silica (CS) causes silicosis, an irreversible lung inflammatory disease that may eventually lead to lung cancer. In this study, we demonstrate that in K-rasLA1 mice, CS exposure markedly ...
    • CXCR3 Controls T-Cell Accumulation in Fat Inflammation 

      Rocha, V. Z.; Folco, Eduardo; Ozdemir, Cafer; Sheikine, Y.; Christen, T.; Sukhova, Galina K.; Tang, E. H. C.; Bittencourt, M. S.; Santos, R. D.; Luster, Andrew David; Cohen, David E; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 2014)
      Objective—Obesity associates with increased numbers of inflammatory cells in adipose tissue (AT), including T cells, but the mechanism of T-cell recruitment remains unknown. This study tested the hypothesis that the chemokine ...
    • Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells 

      Mach, François; Sauty, Alain; Iarossi, Albert S.; Sukhova, Galina K.; Neote, Kuldeep; Libby, Peter; Luster, Andrew David (American Society for Clinical Investigation, 1999)
      Activated T lymphocytes accumulate early in atheroma formation and persist at sites of lesion growth and rupture, suggesting that they may play an important role in the pathogenesis of atherosclerosis. Moreover, atherosclerotic ...
    • Eotaxin Expression after Segmental Allergen Challenge in Subjects with Atopic Asthma 

      Lilly, Craig M.; Nakamura, Hidetoshi; Belostotsky, Olga I.; Haley, Kathleen; Garcia-Zepeda, Eduardo A.; Luster, Andrew; Israel, Elliot (American Thoracic Society, 2001-06)
      Expression of pulmonary eotaxin protein and mRNA was determined in six subjects with atopic asthma and five nonatopic normal subjects. Levels of eotaxin expression and eosinophil mobilization were compared before and after ...
    • Evolutionarily Conserved Recognition and Innate Immunity to Fungal Pathogens by the Scavenger Receptors SCARF1 and CD36 

      Tampakakis, Emmanouil; Puckett, Lindsay; Tai, Melissa F.; Stewart, Cameron R.; Hickman, Suzanne E.; Moore, Kathryn J.; El Khoury, Joseph; Means, Terry K.; Mylonakis, Eleftherios; Colvin, Richard Anthony; Seung, Edward N.; Pukkila-Worley, Read; Calderwood, Stephen Beaven; Hacohen, Nir; Luster, Andrew David (Rockefeller University Press, 2009)
      Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 ...
    • HIV-infected T cells are migratory vehicles for viral dissemination 

      Murooka, Thomas; Deruaz, Maud; Marangoni, Francesco; Vrbanac, Vladimir D.; Seung, Edward N.; Von Andrian, Ulrich H.; Tager, Andrew Martin; Luster, Andrew David; Mempel, Thorsten Roman (2012)
      After host entry through mucosal surfaces, HIV-1 disseminates to lymphoid tissues to establish a generalized infection of the immune system. The mechanisms by which this virus spreads among permissive target cells locally ...
    • The Humanized BLT Mouse to Study HIV Transmission 

      Deruaz, Maud; Murooka, Thomas; Dudek, Timothy E; Vrbanac, VD; Tivet, T; Bankert, KC; Allen, Todd; Tager, Andrew Martin; Luster, Andrew David (BioMed Central, 2012)
    • ICOS-Expressing Lymphocytes Promote Resolution of CD8-Mediated Lung Injury in a Mouse Model of Lung Rejection 

      Wu, Qiang; Gardiner, Gail J.; Berry, Elizabeth; Wagner, Sarah R.; Lu, Tiffany; Clay, Bryan S.; Moore, Tamson V.; Ferreira, Caroline M.; Williams, Jesse W.; Luster, Andrew D.; Medoff, Benjamin D.; Cannon, Judy L.; Sperling, Anne I.; Shilling, Rebecca A. (Public Library of Science, 2013)
      Acute rejection, a common complication of lung transplantation, may promote obliterative bronchiolitis leading to graft failure in lung transplant recipients. During acute rejection episodes, CD8+ T cells can contribute ...
    • Identification of human CCR8 as a CCL18 receptor 

      Islam, Sabina A.; Ling, Morris F.; Leung, John; Shreffler, Wayne G.; Luster, Andrew D. (The Rockefeller University Press, 2013)
      The CC chemokine ligand 18 (CCL18) is one of the most highly expressed chemokines in human chronic inflammatory diseases. An appreciation of the role of CCL18 in these diseases has been hampered by the lack of an identified ...
    • IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection 

      Adoro, Stanley; Cubillos-Ruiz, Juan R.; Chen, Xi; Deruaz, Maud; Vrbanac, Vladimir D.; Song, Minkyung; Park, Suna; Murooka, Thomas T.; Dudek, Timothy E.; Luster, Andrew D.; Tager, Andrew M.; Streeck, Hendrik; Bowman, Brittany; Walker, Bruce D.; Kwon, Douglas S.; Lazarevic, Vanja; Glimcher, Laurie H. (Nature Pub. Group, 2015)
      Initial events after exposure determine HIV-1 disease progression, underscoring a critical need to understand host mechanisms that interfere with initial viral replication. Although associated with chronic HIV-1 control, ...
    • IL-23 Induces Atopic Dermatitis-Like Inflammation Instead of Psoriasis-Like Inflammation in CCR2-Deficient Mice 

      Bromley, Shannon; Larson, Ryan P.; Ziegler, Steven F.; Luster, Andrew David (Public Library of Science, 2013)
      Psoriasis is an immune-mediated chronic inflammatory skin disease, characterized by epidermal hyperplasia and infiltration of leukocytes into the dermis and epidermis. IL-23 is expressed in psoriatic skin, and IL-23 injected ...
    • Leukotriene B4-Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation 

      Oyoshi, Michiko K.; He, Rui; Li, Yitang; Mondal, Subhanjan; Yoon, Juhan; Afshar, Roshi; Chen, Mei; Lee, David M.; Luo, Hongbo; Luster, Andrew David; Cho, John S.; Miller, Lloyd S.; Larson, Allison; Murphy, George Francis; Geha, Raif Salim (Elsevier BV, 2012)
      Scratching triggers skin flares in atopic dermatitis. We demonstrate that scratching of human skin and tape stripping of mouse skin cause neutrophil influx. In mice, this influx was largely dependent on the generation of ...
    • Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4 

      Mikhak, Zamaneh; Strassner, James P.; Luster, Andrew D. (The Rockefeller University Press, 2013)
      T cell trafficking into the lung is critical for lung immunity, but the mechanisms that mediate T cell lung homing are not well understood. Here, we show that lung dendritic cells (DCs) imprint T cell lung homing, as lung ...
    • Neutralizing Anti-HIV Antibodies Develop in a Humanized Mouse Model of HIV-1 Infection 

      Vrbanac, V; Tivey, T; Cariappa, A; Seung, Edward N.; Dugast, Anne-Sophie; Dudek, Timothy E; Mattoo, Hamid Rasheed; Murooka, Thomas; Pillai, Shiv Subramaniam; Tager, Andrew Martin; Luster, Andrew David (BioMed Central, 2012)
    • Novel approach to inhibiting chemokine function 

      Ling, Morris; Luster, Andrew David (WILEY-VCH Verlag, 2011)
    • PD-1 Blockade in Chronically HIV-1-Infected Humanized Mice Suppresses Viral Loads 

      Seung, Edward; Dudek, Timothy E.; Allen, Todd M.; Freeman, Gordon J.; Luster, Andrew D.; Tager, Andrew M. (Public Library of Science, 2013)
      An estimated 34 million people are living with HIV worldwide (UNAIDS, 2012), with the number of infected persons rising every year. Increases in HIV prevalence have resulted not only from new infections, but also from ...