Now showing items 1-5 of 5

    • Genetic Targeting of the Endoderm with Claudin-6CreER 

      Anderson, William J.; Zhou, Qiao; Alcalde, Victor; Kaneko, Osamu F; Blank, Leah J; Sherwood, Richard Irving; Guseh, James Sawalla; Rajagopal, Jayaraj; Melton, Douglas A. (Wiley-Blackwell, 2008)
      A full description of the ontogeny of the β cell would guide efforts to generate β cells from embryonic stem cells (ESCs). The first step requires an understanding of definitive endoderm: the genes and signals responsible ...
    • In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes 

      Li, Weida; Nakanishi, Mio; Zumsteg, Adrian; Shear, Matthew; Wright, Christopher; Melton, Douglas A; Zhou, Qiao (eLife Sciences Publications, Ltd, 2014)
      Direct lineage conversion of adult cells is a promising approach for regenerative medicine. A major challenge of lineage conversion is to generate specific cell subtypes. The pancreatic islets contain three major ...
    • A Multipotent Progenitor Domain Guides Pancreatic Organogenesis 

      Zhou, Qiao; Law, Anica Chi-Ying; Rajagopal, Jayaraj; Anderson, William J.; Gray, Paul A.; Melton, Douglas A. (Elsevier BV, 2007)
      The mammalian pancreas is constructed during embryogenesis by multipotent progenitors, the identity and function of which remain poorly understood. We performed genome-wide transcription factor expression analysis of the ...
    • Notch signaling promotes airway mucous metaplasia and inhibits alveolar development 

      Guseh, James Sawalla; Bores, S. A.; Stanger, B. Z.; Zhou, Qiao; Anderson, William J.; Melton, Douglas A.; Rajagopal, Jayaraj (The Company of Biologists, 2009)
      The airways are conduits that transport atmospheric oxygen to the distal alveolus. Normally, airway mucous cells are rare. However, diseases of the airway are often characterized by mucous metaplasia, in which there are ...
    • De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts 

      Chen, Yi-Ju; Finkbeiner, Stacy R.; Weinblatt, Daniel; Emmett, Matthew J.; Tameire, Feven; Yousefi, Maryam; Yang, Chenghua; Maehr, Rene; Zhou, Qiao; Shemer, Ruth; Dor, Yuval; Li, Changhong; Spence, Jason R.; Stanger, Ben Z. (2014)
      SUMMARY The ability to interconvert terminally differentiated cells could serve as a powerful tool for cell-based treatment of degenerative diseases, including diabetes mellitus. To determine which, if any, adult tissues ...