Browsing by Author "Wu, Hongtan"

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    • The kinases Mst1 and Mst2 positively regulate phagocyte ROS induction and bactericidal activity 

      Geng, Jing; Sun, Xiufeng; Wang, Ping; Zhang, Shihao; Wang, Xiaozhen; Wu, Hongtan; Hong, Lixin; Xie, Changchuan; Li, Xun; Zhao, Hao; Liu, Qingxu; Jiang, Mingting; Chen, Qinghua; Zhang, Jinjia; Li, Yang; Song, Siyang; Wang, Hong-Rui; Zhou, Rongbin; Johnson, Randy L.; Chien, Kun-Yi; Lin, Sheng-Cai; Han, Jiahuai; Avruch, Joseph; Chen, Lanfen; Zhou, Dawang (2015)
      Summary Mitochondria need to be juxtaposted to phagosomes to synergistically produce ample reactive oxygen species (ROS) in phagocytes for pathogens killing. However, how phagosomes transmit signal to recruit mitochondria ...

    • Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance 

      Zhou, Dawang; Zhang, Yongyou; Wu, Hongtan; Barry, Evan; Yin, Yi; Lawrence, Earl; Dawson, Dawn; Willis, Joseph E.; Markowitz, Sanford D.; Camargo, Fernando D.; Avruch, Joseph (National Academy of Sciences, 2011)
      Ablation of the kinases Mst1 and Mst2, orthologs of the Drosophila antiproliferative kinase Hippo, from mouse intestinal epithelium caused marked expansion of an undifferentiated stem cell compartment and loss of secretory ...