Now showing items 1-20 of 129

    • Accumulated Lead Exposure and Risk of Age-Related Cataract in Men 

      Schaumberg, Debra Ann; Mendes, Flavia; Balaram, Mini; Dana, Reza; Sparrow, David; Hu, Howard (American Medical Association (AMA), 2004)
      Context Low-level lead exposure may increase the risk for a number of chronic age-related diseases. Several studies have documented the presence of lead in lenses with cataract. The intrusion of lead into the lens may alter ...
    • Alloimmunity and Tolerance in Corneal Transplantation 

      Amouzegar, Afsaneh; Chauhan, Sunil Kumar; Dana, Reza (The American Association of Immunologists, 2016)
      Corneal transplantation is one of the most prevalent and successful forms of solid tissue transplantation. Despite favorable outcomes, immune-mediated graft rejection still remains the major cause of corneal allograft ...
    • Alteration of Galectin-3 in Tears of Patients With Dry Eye Disease 

      Uchino, Yuichi; Mauris, Jerome; Woodward, Ashley Morgan; Dieckow, Julia; Amparo, Francisco; Dana, Reza; Mantelli, Flavio; Argueso, Pablo (Elsevier BV, 2015)
      Purpose To investigate the expression, release, and proteolytic degradation of galectin-3 in patients with dry eye disease. Design Observational case series with a comparison group. Methods Tear washes and ...
    • Alterations in Corneal Stromal Dendritic Cell Phenotype and Distribution in Inflammation 

      Hamrah, Pedram; Liu, Ying; Zhang, Qiang; Dana, Reza (American Medical Association (AMA), 2003)
      Background The normal corneal stroma is endowed with large numbers of resident dendritic cells (DCs). The purpose of this study was to examine the phenotype and distribution of these cells in inflammation. Methods ...
    • Amelioration of Murine Dry Eye Disease by Topical Antagonist to Chemokine Receptor 2 

      Goyal, Sunali; Chauhan, Sunil Kumar; Zhang, Qiang; Dana, Reza (American Medical Association (AMA), 2009)
      Objective To determine the effect of a topical antagonist to the chemokine receptor 2 (CCR2) in a murine model of dry eye disease. Methods The effects of a topical CCR2 antagonist and a vehicle control treatment were ...
    • Animal Models of Dry Eye: A Critical Assessment of Opportunities and Limitations 

      Barabino, Stefano; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2004)
    • Anti-angiogenesis Effect of the Novel Anti-inflammatory and Pro-resolving Lipid Mediators 

      Jin, Yiping; Arita, Makoto; Zhang, Qiang; Saban, Daniel R.; Chauhan, Sunil Kumar; Chiang, Nan; Serhan, Charles Nicholas; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2009)
      Purpose.Resolvins and lipoxins are lipid mediators generated from essential polyunsaturated fatty acids that are the first dual anti-inflammatory and pro-resolving signals identified in the resolution phase of inflammation. ...
    • Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage 

      Fuchsluger, T A; Jurkunas, Ula V.; Kazlauskas, Andrius; Dana, Reza (Springer Nature, 2011)
      Corneal transplantation is the most common form of grafting performed worldwide. Corneal endothelial cells (EC) form a monolayer in the posterior portion of the cornea and are essential for corneal transparency. EC loss ...
    • Autoimmunity in Dry Eye Is Due to Resistance of Th17 to Treg Suppression 

      Chauhan, Sunil Kumar; El Annan, Jaafar; Ecoiffier, Tatiana; Goyal, Sunali; Zhang, Q.; Saban, Daniel R.; Dana, Reza (The American Association of Immunologists, 2009)
      Dry eye disease (DED), an inflammatory autoimmune disorder affecting the ocular surface, degrades visual performance and the quality of life of more than 10 million people in the United States alone. The primary limitation ...
    • b-FGF Induces Corneal Blood and Lymphatic Vessel Growth in a Spatially Distinct Pattern 

      Hajrasouliha, Amir R.; Sadrai, Zahra; Chauhan, Sunil Kumar; Dana, Reza (Ovid Technologies (Wolters Kluwer Health), 2012)
      Purpose To study the spatial variances in ligand expression and angiogenic effect in response to the inflammatory response induced by b-FGF. Methods b-FGF micropellets (80ng) were implanted in the temporal side ...
    • Bilateral corneal ulceration in ocular graft-versus-host disease 

      Stevenson, William; Shikari, Hasanain; Saboo, Ujwala; Amparo, Francisco; Dana, Reza (Dove Medical Press Ltd., 2013)
      Purpose To report on corneal ulceration in ocular graft-versus-host disease (GVHD). Methods This was a retrospective, observational case series investigating corneal ulceration and perforation in a cohort of ocular ...
    • Blockade of CD40-CD154 Costimulatory Pathway Promotes Survival of Allogeneic Corneal Transplants 

      Qian, Ying; Boisgerault, Florence; Benichou, Gilles A.; Dana, Reza (Association for Research in Vision and Ophthalmology, 2001)
      purpose. To determine the effect of systemic anti-CD154 monoclonal antibody on the survival of orthotopic murine corneal transplants. methods. BALB/c mice were used as recipients of syngeneic, multiple minor histocompatability ...
    • Blockade of Prolymphangiogenic Vascular Endothelial Growth Factor C in Dry Eye Disease 

      Goyal, Sunali; Chauhan, Sunil Kumar; Dana, Reza (American Medical Association (AMA), 2012)
      Objective To determine if blocking prolymphangiogenic factors like VEGF-C would suppress alloimmunity in dry eye disease (DED) using a murine model. Methods The effects of intraperitoneal injections of 400 μg of ...
    • CCL-21 Conditioned Regulatory T Cells Induce Allotolerance through Enhanced Homing to Lymphoid Tissue 

      Chauhan, Sunil Kumar; Saban, Daniel R.; Dohlman, Thomas H.; Dana, Reza (The American Association of Immunologists, 2013)
      Regulatory T cells (Tregs) are instrumental in the induction and maintenance of tolerance, including in transplantation. Tregs induce allotolerance by interacting with antigen-presenting cells (APC) and T cells, interactions ...
    • CCR5 Chemokine Receptor Mediates Recruitment of MHC Class II-Positive Langerhans Cells in the Mouse Corneal Epithelium 

      Yamagami, Satoru; Hamrah, Pedram; Miyamoto, Kazuhisa; Miyazaki, Dai; Dekaris, Iva; Dawson, Tracey; Lu, Bao; Gerard, Craig; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2005)
      purpose. To characterize the chemokines and chemokine receptors that mediate the effect of proinflammatory cytokines, interleukin (IL)-1 and tumor necrosis factor (TNF)-α, on the recruitment of MHC class II+ Langerhans ...
    • The CCR6/CCL20 Axis Mediates Th17 Cell Migration to the Ocular Surface in Dry Eye Disease 

      Dohlman, Thomas H.; Chauhan, Sunil Kumar; Kodati, Shilpa; Hua, Jing; Chen, Yihe; Omoto, Masahiro; Sadrai, Zahra; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2013)
      Purpose. Th17 cells are believed to be the primary effector cells in the pathogenesis of dry eye disease (DED). However, the mechanisms by which Th17 cells migrate from the lymphoid tissues to the ocular surface are ...
    • CCR7 Is Critical for the Induction and Maintenance of Th17 Immunity in Dry Eye Disease 

      Kodati, Shilpa; Chauhan, Sunil Kumar; Chen, Yihe; Dohlman, Thomas H.; Karimian, Parisa; Saban, Daniel; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2014)
      Purpose. We characterized antigen-presenting cell (APC)–relevant chemokine receptor expression in dry eye disease (DED), and investigated the effect of topical CC chemokine receptor (CCR)-7 blockade specifically on Th17 ...
    • Cellular Changes of the Corneal Epithelium and Stroma in Herpes Simplex Keratitis 

      Hamrah, Pedram; Sahin, Afsun; Dastjerdi, Mohammad H.; Shahatit, Bashar M.; Bayhan, Hasan A.; Dana, Reza; Pavan-Langston, Deborah (Elsevier BV, 2012)
      Purpose To analyze the morphology of corneal epithelial cells and keratocytes by in vivo confocal microscopy (IVCM) in patients with herpes simplex keratitis (HSK) as associated with corneal innervation. Design ...
    • Change in Prostaglandin Expression Levels and Synthesizing Activities in Dry Eye Disease 

      Shim, Jongwoo; Park, Changhun; Lee, Hyun Soo; Park, Min Soo; Lim, Hyung Taek; Chauhan, Sunil Kumar; Dana, Reza; Lee, Hyon; Lee, Hyung Keun (Elsevier BV, 2012)
      Objective To investigate the expression level of prostaglandins (PGs) and their de novo synthesis in dry eye (DE) disease. Design Cross-sectional case-control study and in vivo mouse experimental study. Parti ...
    • Characterization of Effector T Cells in Dry Eye Disease 

      Annan, Jaafar; Chauhan, Sunil; Ecoiffier, Tatiana; Zhang, Qiang; Saban, Daniel; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2009)
      purpose. Dry eye disease (DED) is associated with ocular surface inflammation that is thought to be mediated primarily by CD4 T cells. The purpose of this study was to investigate whether this T cell–mediated immune response ...