Now showing items 1-6 of 6

    • HIV-1-Induced Small T Cell Syncytia Can Transfer Virus Particles to Target Cells through Transient Contacts 

      Symeonides, Menelaos; Murooka, Thomas T.; Bellfy, Lauren N.; Roy, Nathan H.; Mempel, Thorsten R.; Thali, Markus (MDPI, 2015)
      HIV-1 Env mediates fusion of viral and target cell membranes, but it can also mediate fusion of infected (producer) and target cells, thus triggering the formation of multinucleated cells, so-called syncytia. Large, round, ...
    • HIV-infected T cells are migratory vehicles for viral dissemination 

      Murooka, Thomas; Deruaz, Maud; Marangoni, Francesco; Vrbanac, Vladimir D.; Seung, Edward N.; Von Andrian, Ulrich H.; Tager, Andrew Martin; Luster, Andrew David; Mempel, Thorsten Roman (2012)
      After host entry through mucosal surfaces, HIV-1 disseminates to lymphoid tissues to establish a generalized infection of the immune system. The mechanisms by which this virus spreads among permissive target cells locally ...
    • A Near-Infrared Cell Tracker Reagent for Multiscopic In Vivo Imaging and Quantification of Leukocyte Immune Responses 

      Berger, Cedric R.; Figueiredo, Jose-Luiz; Swirski, Filip K.; Mempel, Thorsten Roman; Von Andrian, Ulrich H.; Pittet, Mikael J.; Weissleder, Ralph (Public Library of Science, 2007)
      The complexity of the tumor microenvironment necessitates that cell behavior is studied in a broad, multi-scale context. Although tomographic and microscopy-based far and near infrared fluorescence (NIRF, >650 nm) imaging ...
    • PEG-Like Nanoprobes: Multimodal, Pharmacokinetically and Optically Tunable Nanomaterials 

      Guo, Yanyan; Yuan, Hushan; Claudio, Natalie M.; Kura, Sreekanth; Shakerdge, Naomi; Mempel, Thorsten R.; Bacskai, Brian J.; Josephson, Lee (Public Library of Science, 2014)
      “PEG-like Nanoprobes” (PN’s) are pharmacokinetically and optically tunable nanomaterials whose disposition in biological systems can be determined by fluorescence or radioactivity. PN’s feature a unique design where a ...
    • A single glycan on IgE is indispensable for initiation of anaphylaxis 

      Shade, Kai-Ting C.; Platzer, Barbara; Washburn, Nathaniel; Mani, Vinidhra; Bartsch, Yannic C.; Conroy, Michelle; Pagan, Jose D.; Bosques, Carlos; Mempel, Thorsten R.; Fiebiger, Edda; Anthony, Robert M. (The Rockefeller University Press, 2015)
      Immunoglobulin ε (IgE) antibodies are the primary mediators of allergic diseases, which affect more than 1 in 10 individuals worldwide. IgE specific for innocuous environmental antigens, or allergens, binds and sensitizes ...
    • Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters 

      Lai, Charles P.; Kim, Edward Y.; Badr, Christian E.; Weissleder, Ralph; Mempel, Thorsten R.; Tannous, Bakhos A.; Breakefield, Xandra O. (Nature Pub. Group, 2015)
      Accurate spatiotemporal assessment of extracellular vesicle (EV) delivery and cargo RNA translation requires specific and robust live-cell imaging technologies. Here we engineer optical reporters to label multiple EV ...