Now showing items 1-2 of 2

    • Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer 

      Bowman-Colin, Christian; Xia, B.; Bunting, S.; Klijn, C.; Drost, R.; Bouwman, P.; Fineman, L.; Chen, X.; Culhane, Aedin; Cai, H.; Rodig, Scott J.; Bronson, Roderick Terry; Jonkers, J.; Nussenzweig, A.; Kanellopoulou, C.; Livingston, David Morse (Proceedings of the National Academy of Sciences, 2013)
      Germ-line mutations in PALB2 lead to a familial predisposition to breast and pancreatic cancer or to Fanconi Anemia subtype N. PALB2 performs its tumor suppressor role, at least in part, by supporting homologous ...
    • RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites 

      Sobhian, B.; Shao, G.; Lilli, D. R.; Culhane, Aedin; Moreau, Lisa; Xia, B.; Livingston, David Morse; Greenberg, R. A. (American Association for the Advancement of Science (AAAS), 2007)
      Mutations affecting the BRCT domains of the breast cancer–associated tumor suppressor BRCA1 disrupt the recruitment of this protein to DNA double-strand breaks (DSBs). The molecular structures at DSBs recognized by BRCA1 ...