Browsing by Author "Yuki, Koichi"
Now showing items 1-2 of 2
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An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2
Sen, Mehmet; Yuki, Koichi; Springer, Timothy A. (The Rockefeller University Press, 2013)How is massive conformational change in integrins achieved on a rapid timescale? We report crystal structures of a metastable, putative transition state of integrin αXβ2. The αXβ2 ectodomain is bent; however, a lattice ... -
Stereoselectivity of Isoflurane in Adhesion Molecule Leukocyte Function-Associated Antigen-1
Bu, Weiming; Pereira, Luis M.; Eckenhoff, Roderic G.; Yuki, Koichi (Public Library of Science, 2014)Background: Isoflurane in clinical use is a racemate of S- and R-isoflurane. Previous studies have demonstrated that the effects of S-isoflurane on relevant anesthetic targets might be modestly stronger (less than 2-fold) ...