Browsing by Author "Tanaka, Atsushi"

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    • PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin 

      Narendra, Derek P.; Jin, Seok Min; Tanaka, Atsushi; Suen, Der-Fen; Gautier, Clement A.; Shen, Jie; Cookson, Mark R.; Youle, Richard J. (Public Library of Science, 2010)
      Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their ...