Browsing by Author "Sasisekharan, Ram"
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Determinants of Glycan Receptor Specificity of H2N2 Influenza A Virus Hemagglutinin
Viswanathan, Karthik; Koh, Xiaoying; Chandrasekaran, Aarthi; Pappas, Claudia; Raman, Rahul; Srinivasan, Aravind; Shriver, Zachary; Tumpey, Terrence M.; Sasisekharan, Ram (Public Library of Science, 2010)The H2N2 subtype of influenza A virus was responsible for the Asian pandemic of 1957-58. However, unlike other subtypes that have caused pandemics such as H1N1 and H3N2, which continue to circulate among humans, H2N2 stopped ... -
Modular glycosphere assays for high-throughput functional characterization of influenza viruses
Hobbie, Sven N; Viswanathan, Karthik; Bachelet, Ido; Aich, Udayanath; Shriver, Zachary; Subramanian, Vidya; Raman, Rahul; Sasisekharan, Ram (BioMed Central, 2013)Background: The ongoing global efforts to control influenza epidemics and pandemics require high-throughput technologies to detect, quantify, and functionally characterize viral isolates. The 2009 influenza pandemic as ... -
Receptor Specificity and Transmission of H2N2 Subtype Viruses Isolated from the Pandemic of 1957
Pappas, Claudia; Viswanathan, Karthik; Chandrasekaran, Aarthi; Raman, Rahul; Katz, Jacqueline M.; Sasisekharan, Ram; Tumpey, Terrence M. (Public Library of Science, 2010)Influenza viruses of the H2N2 subtype have not circulated among humans in over 40 years. The occasional isolation of avian H2 strains from swine and avian species coupled with waning population immunity to H2 hemagglutinin ... -
A Single Base-Pair Change in 2009 H1N1 Hemagglutinin Increases Human Receptor Affinity and Leads to Efficient Airborne Viral Transmission in Ferrets
Jayaraman, Akila; Pappas, Claudia; Raman, Rahul; Belser, Jessica A.; Viswanathan, Karthik; Shriver, Zachary; Tumpey, Terrence M.; Sasisekharan, Ram (Public Library of Science, 2011)The 2009 H1N1 influenza A virus continues to circulate among the human population as the predominant H1N1 subtype. Epidemiological studies and airborne transmission studies using the ferret model have shown that the ...