Browsing by Author "Saslowsky, David E."
Now showing items 1-4 of 4
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Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W
Reimold, Fabian R.; Balasubramanian, Savithri; Doroquez, David B.; Shmukler, Boris E.; Zsengeller, Zsuzsanna K.; Saslowsky, David; Thiagarajah, Jay R.; Stillman, Isaac E.; Lencer, Wayne I.; Wu, Bai-Lin; Villalpando-Carrion, Salvador; Alper, Seth L. (Frontiers Media S.A., 2015)Congenital chloride diarrhea is an autosomal recessive disease caused by mutations in the intestinal lumenal membrane Cl−/HCO−3 exchanger, SLC26A3. We report here the novel SLC26A3 mutation G393W in a Mexican child, the ... -
Functional Analysis of VopF Activity Required for Colonization in Vibrio cholerae
Tam, Vincent C.; Suzuki, Masato; Coughlin, Margaret; Saslowsky, David; Biswas, Kuntal; Lencer, Wayne Isaac; Faruque, Shah M.; Mekalanos, John J. (American Society of Microbiology, 2010)Vibrio cholerae, a Gram-negative facultative pathogen, is the etiologic agent for the diarrheal disease cholera. We previously characterized a clinical isolate, AM-19226, that translocates a type III secretion system (T3SS) ... -
Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion
Saslowsky, David E.; Thiagarajah, Jay R.; McCormick, Beth A.; Lee, Jean C.; Lencer, Wayne I. (The American Society for Cell Biology, 2016)The apical brush border membrane (BBM) of intestinal epithelial cells forms a highly structured and dynamic environmental interface that serves to regulate cellular physiology and block invasion by intestinal microbes and ... -
Staphylococcus aureus Colonization of the Mouse Gastrointestinal Tract Is Modulated by Wall Teichoic Acid, Capsule, and Surface Proteins
Misawa, Yoshiki; Kelley, Kathryn A.; Wang, Xiaogang; Wang, Linhui; Park, Wan Beom; Birtel, Johannes; Saslowsky, David; Lee, Jean C. (Public Library of Science, 2015)Staphylococcus aureus colonizes the nose, throat, skin, and gastrointestinal (GI) tract of humans. GI carriage of S. aureus is difficult to eradicate and has been shown to facilitate the transmission of the bacterium among ...