Now showing items 1-4 of 4

    • Molecular basis of caspase-1 polymerization and its inhibition by a novel capping mechanism 

      Lu, Alvin; Li, Yang; Schmidt, Florian I.; Yin, Qian; Chen, Shuobing; Fu, Tian-Min; Tong, Alexander B.; Ploegh, Hidde L.; Mao, Youdong; Wu, Hao (2016)
      Inflammasomes are cytosolic caspase-1 activation complexes that sense intrinsic and extrinsic danger signals to trigger inflammatory responses and pyroptotic cell death. Homotypic interactions by Pyrin domains (PYD) and ...
    • Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer 

      Mao, Youdong; Wang, Liping; Gu, Christopher H.; Herschhorn, Alon Menachem; Xiang, Shi-Hua; Haim, Hillel; Yang, Xinzhen; Sodroski, Joseph Gerard (2012)
      The trimeric human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) spike is a molecular machine that mediates virus entry into host cells and is the sole target for virus-neutralizing antibodies. The ...
    • A Twin-Cysteine Motif in the V2 Region of gp120 Is Associated with SIV Envelope Trimer Stabilization 

      Bohl, Christopher; Bowder, Dane; Thompson, Jesse; Abrahamyan, Levon; Gonzalez-Ramirez, Sandra; Mao, Youdong; Sodroski, Joseph; Wood, Charles; Xiang, Shi-hua (Public Library of Science, 2013)
      The V1 and V2 variable regions of the primate immunodeficiency viruses contribute to the trimer association domain of the gp120 exterior envelope glycoprotein. A pair of V2 cysteine residues at 183 and 191 (“twin cysteines”) ...
    • Unsupervised Cryo-EM Data Clustering through Adaptively Constrained K-Means Algorithm 

      Xu, Yaofang; Wu, Jiayi; Yin, Chang-Cheng; Mao, Youdong (Public Library of Science, 2016)
      In single-particle cryo-electron microscopy (cryo-EM), K-means clustering algorithm is widely used in unsupervised 2D classification of projection images of biological macromolecules. 3D ab initio reconstruction requires ...