Now showing items 1-10 of 10

    • The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer 

      Cotter, Kristina; Liberman, Rachel; Sun-Wada, GeHong; Wada, Yoh; Sgroi, Dennis; Naber, Stephen; Brown, Dennis; Breton, Sylvie; Forgac, Michael (Impact Journals LLC, 2016)
      The vacuolar (H+)-ATPases (V-ATPases) are a family of ATP-driven proton pumps that acidify intracellular compartments and transport protons across the plasma membrane. Previous work has demonstrated that plasma membrane ...
    • Assessment of the prognostic and predictive utility of the Breast Cancer Index (BCI): an NCIC CTG MA.14 study 

      Sgroi, Dennis C.; Chapman, Judy-Anne W.; Badovinac-Crnjevic, T.; Zarella, Elizabeth; Binns, Shemeica; Zhang, Yi; Schnabel, Catherine A.; Erlander, Mark G.; Pritchard, Kathleen I.; Han, Lei; Shepherd, Lois E.; Goss, Paul E.; Pollak, Michael (BioMed Central, 2016)
      Background: Biomarkers that can be used to accurately assess the residual risk of disease recurrence in women with hormone receptor–positive breast cancer are clinically valuable. We evaluated the prognostic value of the ...
    • A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity 

      McMullin, Ryan P; Wittner, Ben S; Yang, Chuanwei; Denton-Schneider, Benjamin R; Hicks, Daniel; Singavarapu, Raj; Moulis, Sharon; Lee, Jeongeun; Akbari, Mohammad R; Narod, Steven A; Aldape, Kenneth D; Steeg, Patricia S; Ramaswamy, Sridhar; Sgroi, Dennis C (BioMed Central, 2014)
      Introduction: There is an unmet clinical need for biomarkers to identify breast cancer patients at an increased risk of developing brain metastases. The objective is to identify gene signatures and biological pathways ...
    • Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes 

      Marselli, Lorella; Thorne, Jeffrey; Dahiya, Sonika; Sgroi, Dennis Charles; Sharma, Arun J.; Bonner-Weir, Susan; Weir, Gordon Campbell; Marchetti, Piero (Public Library of Science, 2010)
      Background: Changes in gene expression in pancreatic beta-cells from type 2 diabetes (T2D) should provide insights into their abnormal insulin secretion and turnover. Methodology/Principal Findings: Frozen sections were ...
    • Identification and Rational Redesign of Peptide Ligands to CRIP1, A Novel Biomarker for Cancers 

      Hao, Jihua; Serohijos, Adrian; Newton, Gail; Tassone, Gina; Wang, Zuncai; Sgroi, Dennis Charles; Dokholyan, Nikolay V.; Basilion, James P. (Public Library of Science, 2008)
      Cysteine-rich intestinal protein 1 (CRIP1) has been identified as a novel marker for early detection of cancers. Here we report on the use of phage display in combination with molecular modeling to identify a high-affinity ...
    • Prevalence and Predictors of Loss of Wild Type BRCA1 in Estrogen Receptor Positive and Negative BRCA1-Associated Breast Cancers 

      Fetten, Katharina; Yassin, Yosuf; Buraimoh, Ayodele; Kim, Ji-Young; Legare, Robert D; Tung, Nadine Muskatel; Miron, Alexander; Schnitt, Stuart Jay; Gautam, Shiva Prasad; Kaplan, Jennifer; Szasz, Attila M.; Tian, Ruiyang; Wang, Zhigang C.; Collins, Laura Christine; Brock, Jane Elizabeth; Krag, Karen; Sgroi, Dennis Charles; Ryan, Paula D.; Silver, Daniel P.; Garber, Judy Ellen; Richardson, Andrea Lynn (BioMed Central, 2010)
      Introduction: The majority of breast cancers that occur in BRCA1 mutation carriers (BRCA1 carriers) are estrogen receptor-negative (ER-). Therefore, it has been suggested that ER negativity is intrinsic to BRCA1 cancers ...
    • Protective Unfolded Protein Response in Human Pancreatic Beta Cells Transplanted into Mice 

      Kennedy, Jeffrey; Katsuta, Hitoshi; Jung, Min-Ho; Marselli, Lorella; Goldfine, Allison Braunwald; Balis, Ulysses J.; Sgroi, Dennis Charles; Bonner-Weir, Susan; Weir, Gordon Campbell (Public Library of Science, 2010)
      Background: There is great interest about the possible contribution of ER stress to the apoptosis of pancreatic beta cells in the diabetic state and with islet transplantation. Methods and Findings: Expression of genes ...
    • Re-evaluating Early Breast Neoplasia 

      Moulis, Sharon; Sgroi, Dennis Charles (BioMed Central, 2008)
      Historically, histomorphological and epidemiological data suggested that atypical ductal hyperplasia and ductal carcinoma in situ are the earliest recognizable neoplastic stages of breast cancer progression. Over the past ...
    • Resolving Cancer-Stroma Interfacial Signaling and Interventions with Micropatterned Tumor-Stromal Assays 

      Shen, Keyue; Luk, Samantha; Hicks, Daniel F; Elman, Jessica S; Bohr, Stefan; Iwamoto, Yoshiko; Murray, Ryan; Pena, Kristen; Wang, Fangjing; Seker, Erkin; Weissleder, Ralph; Yarmush, Martin L; Toner, Mehmet; Sgroi, Dennis; Parekkadan, Biju (2014)
      Tumor-stromal interactions are a determining factor in cancer progression. In vivo, the interaction interface is associated with spatially-resolved distributions of cancer and stromal phenotypes. Here, we establish a ...
    • Tumor antigens as proteogenomic biomarkers in invasive ductal carcinomas 

      Olsen, Lars Rønn; Campos, Benito; Winther, Ole; Sgroi, Dennis C; Karger, Barry L; Brusic, Vladimir (BioMed Central, 2014)
      Background: The majority of genetic biomarkers for human cancers are defined by statistical screening of high-throughput genomics data. While a large number of genetic biomarkers have been proposed for diagnostic and ...