Now showing items 1-6 of 6

    • Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome 

      Hall, Kathryn Tayo; Lembo, Anthony J.; Kirsch, Irving; Ziogas, Dimitrios C.; Douaiher, Jeffrey; Jensen, Karin; Conboy, Lisa Ann; Kelley, John Michael; Kokkotou, Efi G.; Kaptchuk, Ted Jack (Public Library of Science, 2012)
      Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in ...
    • A Neural Mechanism for Nonconscious Activation of Conditioned Placebo and Nocebo Responses 

      Jensen, Karin B.; Kaptchuk, Ted J.; Chen, Xiaoyan; Kirsch, Irving; Ingvar, Martin; Gollub, Randy L.; Kong, Jian (Oxford University Press, 2014)
      Fundamental aspects of human behavior operate outside of conscious awareness. Yet, theories of conditioned responses in humans, such as placebo and nocebo effects on pain, have a strong emphasis on conscious recognition ...
    • Patients with fibromyalgia display less functional connectivity in the brain’s pain inhibitory network 

      Jensen, Karin; Loitoile, Rita; Kosek, Eva; Petzke, Frank; Carville, Serena; Fransson, Peter; Marcus, Hanke; Williams, Steven CR; Choy, Ernest; Mainguy, Yves; Vitton, Olivier; Gracely, Richard H; Gollub, Randy L.; Ingvar, Martin; Kong, Jian (BioMed Central, 2012)
      Background: There is evidence for augmented processing of pain and impaired endogenous pain inhibition in Fibromyalgia syndrome (FM). In order to fully understand the mechanisms involved in FM pathology, there is a need ...
    • Placebo Responses in Genetically Determined Intellectual Disability: A Meta-Analysis 

      Curie, Aurore; Yang, Kathy; Kirsch, Irving; Gollub, Randy L.; des Portes, Vincent; Kaptchuk, Ted J.; Jensen, Karin B. (Public Library of Science, 2015)
      Background: Genetically determined Intellectual Disability (ID) is an intractable condition that involves severe impairment of mental abilities such as learning, reasoning and predicting the future. As of today, little is ...
    • S1 is associated with chronic low back pain: a functional and structural MRI study 

      Kong, Jian; Spaeth, Rosa B; Wey, Hsiao-Ying; Cheetham, Alexandra; Cook, Amanda H; Jensen, Karin; Tan, Ying; Liu, Hesheng; Wang, Danhong; Loggia, Marco L; Napadow, Vitaly; Smoller, Jordan W; Wasan, Ajay D; Gollub, Randy L (BioMed Central, 2013)
      A fundamental characteristic of neural circuits is the capacity for plasticity in response to experience. Neural plasticity is associated with the development of chronic pain disorders. In this study, we investigated 1) ...
    • Well-Loved Music Robustly Relieves Pain: A Randomized, Controlled Trial 

      Hsieh, Christine; Kong, Jian; Kirsch, Irving; Edwards, Robert R.; Jensen, Karin B.; Kaptchuk, Ted J.; Gollub, Randy L. (Public Library of Science, 2014)
      Music has pain-relieving effects, but its mechanisms remain unclear. We sought to verify previously studied analgesic components and further elucidate the underpinnings of music analgesia. Using a well-characterized ...