Browsing by Author "Alexander, Mark"
Now showing items 1-4 of 4
-
Capturing Pain in the Cortex during General Anesthesia: Near Infrared Spectroscopy Measures in Patients Undergoing Catheter Ablation of Arrhythmias
Kussman, Barry D.; Aasted, Christopher M.; Yücel, Meryem A.; Steele, Sarah C.; Alexander, Mark E.; Boas, David A.; Borsook, David; Becerra, Lino (Public Library of Science, 2016)The predictability of pain makes surgery an ideal model for the study of pain and the development of strategies for analgesia and reduction of perioperative pain. As functional near-infrared spectroscopy reproduces the ... -
A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia
Lobo, Kimberly; Donado, Carolina; Cornelissen, Laura Louise; Kim, Joseph; Ortiz, Rebeca; Peake, Roy; Kellogg, Mark David; Alexander, Mark Edward; Zurakowski, David; Kurgansky, Katherine E.; Peyton, James Matthew; Bilge, Aykut; Boretsky, Karen Rach; McCann, Mary Ellen; Berde, Charles Benjamin; Cravero, Joseph Peter (Ovid Technologies (Wolters Kluwer Health), 2015)BACKGROUND: Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker that produces prolonged local anesthesia in animals and humans. Under a Food and Drug Administration-approved phase 1 Investigational New Drug trial, ... -
Regional Implementation of a Pediatric Cardiology Syncope Algorithm Using Standardized Clinical Assessment and Management Plans (SCAMPS) Methodology
Paris, Yvonne; Toro‐Salazar, Olga H.; Gauthier, Naomi S.; Rotondo, Kathleen M.; Arnold, Lucy; Hamershock, Rose; Saudek, David E.; Fulton, David R.; Renaud, Ashley; Alexander, Mark E. (John Wiley and Sons Inc., 2016)Background: Pediatric syncope is common. Cardiac causes are rarely found. We describe and assess a pragmatic approach to these patients first seen by a pediatric cardiologist in the New England region, using Standardized ... -
Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome
Khwaja, O. S.; Ho, E.; Barnes, K. V.; O, H. M.; Pereira, Luis Marcelo; Finkelstein, Y.; Nelson, Charles A.; Vogel-Farley, V.; DeGregorio, G.; Holm, Ingrid Adele; Khatwa, Umakanth A.; Kapur, Kush; Alexander, Mark Edward; Finnegan, D. M.; Cantwell, N. G.; Walco, A. C.; Rappaport, Leonard Allan; Gregas, M.; Fichorova, Raina Nakova; Shannon, M. W.; Sur, M.; Kaufmann, Walter E (Proceedings of the National Academy of Sciences, 2014)Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder mainly affecting females and is associated with mutations in MECP2, the gene encoding methyl CpG-binding protein 2. Mouse models suggest that recombinant ...