Browsing by Author "Lederer, James"

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    • Efficacy of Antibody to PNAG Against Keratitis Caused by Fungal Pathogens 

      Zhao, Ge; Zaidi, Tanweer S.; Bozkurt-Guzel, Cagla; Zaidi, Tauqeer H.; Lederer, James A.; Priebe, Gregory P.; Pier, Gerald B. (The Association for Research in Vision and Ophthalmology, 2016)
      Purpose Developing immunotherapies for fungal eye infections is a high priority. We analyzed fungal pathogens for expression of the surface polysaccharide, poly-N-acetyl glucosamine (PNAG), and used a mouse model of ocular ...

    • Pathologically Expanded Peripheral T Helper Cell Subset Drives B Cells in Rheumatoid Arthritis 

      Rao, Deepak; Gurish, Michael F.; Marshall, Jennifer L.; Slowikowski, Kamil; Fonseka, Chamith Y.; Liu, Yanyan; Donlin, Laura T.; Henderson, Lauren; Wei, Kevin; Mizoguchi, Fumitaka; Teslovich, Nikola; Weinblatt, Michael; Massarotti, Elena; Coblyn, Jonathan; Helfgott, Simon; Lee, Yvonne C.; Todd, Derrick; Bykerk, Vivian P.; Goodman, Susan M.; Pernis, Alessandra B.; Ivashkiv, Lionel B.; Karlson, Elizabeth; Nigrovic, Peter; Filer, Andrew; Buckley, Christopher D.; Lederer, James; Raychaudhuri, Soumya; Brenner, Michael (Springer Science and Business Media LLC, 2017-02-02)
      CD4+ T cells are central mediators of autoimmune pathology; however, defining their key effector functions in specific autoimmune diseases remains challenging. Pathogenic CD4+ T cells within affected tissues may be identified ...