Browsing by Author "DeAngelo, Daniel"

Now showing items 1-8 of 8

    • Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease 

      Bradner, James Elliott; Mak, Raymond Heungwing; Tanguturi, Shyam Kumar; Mazitschek, Ralph; Haggarty, Stephen John; Ross, Kenneth N; Chang, Cindy Y.; Bosco, Jocelyn; West, Nathan; Morse, Elizabeth; Lin, Katherine; Shen, John Paul; Kwiatkowski, Nicholas Paul; Gheldof, Nele; Dekker, Job; DeAngelo, Daniel J.; Carr, Steven A.; Schreiber, Stuart L.; Golub, Todd Robert; Ebert, Benjamin L. (Proceedings of the National Academy of Sciences, 2010)
      The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year in Africa alone. Induction of fetal hemoglobin is a validated strategy to improve symptoms and complications ...

    • Detecting T-cell Reactivity to Whole Cell Vaccines 

      Brusic, Ana; Hainz, Ursula; Wadleigh, Martha; Neuberg, Donna; Su, Mei; Canning, Christine M.; DeAngelo, Daniel J.; Stone, Richard M.; Lee, Jeng-Shin; Mulligan, Richard C.; Ritz, Jerome; Dranoff, Glenn; Sasada, Tetsuro; Wu, Catherine J. (Landes Bioscience, 2012)
      BCR-ABL\(^+\) K562 cells hold clinical promise as a component of cancer vaccines, either as bystander cells genetically modified to express immunostimulatory molecules, or as a source of leukemia antigens. To develop a ...

    • HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia 

      Akahane, Koshi; Sanda, Takaomi; Mansour, Marc R.; Radimerski, Thomas; DeAngelo, Daniel J.; Weinstock, David M.; Look, A. Thomas (2015)
      We previously found that TYK2 tyrosine kinase signaling through its downstream effector phospho-STAT1 (p-STAT1) acts to upregulate BCL2, which in turn mediates aberrant survival of T-cell acute lymphoblastic leukemia (T-ALL) ...

    • Insulin receptor substrate 1 is a substrate of the Pim protein kinases 

      Song, Jin H.; Padi, Sathish K. R.; Luevano, Libia A.; Minden, Mark D.; DeAngelo, Daniel J.; Hardiman, Gary; Ball, Lauren E.; Warfel, Noel A.; Kraft, Andrew S. (Impact Journals LLC, 2016)
      The Pim family of serine/threonine protein kinases (Pim 1, 2, and 3) contribute to cellular transformation by regulating glucose metabolism, protein synthesis, and mitochondrial oxidative phosphorylation. Drugs targeting ...

    • RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability 

      Chen, Edwin; Ahn, Jong Sook; Sykes, David Brian; Breyfogle, Lawrence J.; Godfrey, Anna L.; Nangalia, Jyoti; Ko, Amy; DeAngelo, Daniel J.; Green, Alexander Robert; Mullally, Ann (Elsevier BV, 2015)
      JAK2V617F is the most common oncogenic lesion in patients with myeloproliferative neoplasms (MPNs). Despite the ability of JAK2V617F to instigate DNA damage in vitro, MPNs are nevertheless characterized by genomic stability. ...

    • The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy 

      Wang, Leo; Rao, Tirzah; Rowe, Robert Grant; Nguyen, Phi; Sullivan, Jessica J; Pearson, Daniel Stark; Doulatov, Sergei; Wu, Linwei; Lindsley, Robert Coleman; Zhu, Hao; DeAngelo, Daniel J.; Daley, George Quentin; Wagers, Amy Jo (Nature Publishing Group, 2015)
      Mast cells are critical components of the innate immune system and important for host 48 defense, allergy, autoimmunity, tissue regeneration, and tumor progression.Dysregulated 49 mastcell development leads to systemic ...

    • SYK Regulates mTOR Signaling in AML 

      Carnevale, Julia; Ross, Linda; Puissant, Alexandre; Banerji, Versha; Stone, Richard M.; DeAngelo, Daniel J.; Ross, Kenneth N.; Stegmaier, Kimberly (2014)
      Spleen Tyrosine Kinase (SYK) was recently identified as a new target in acute myeloid leukemia (AML); however, its mechanistic role in this disease is poorly understood. Based on the known interaction between SYK and mTOR ...

    • Targeting the Creatine Kinase Pathway in EVI1-Positive Acute Myeloid Leukemia 

      Fenouille, Nina; Bassil, Christopher; Ben-Sahra, Issam; Benajiba, Lina; Alexe, Gabriela; Ramos, Azucena; Pikman, Yana; Conway, Amy; Burgess, Michael; Li, Qing; Luciano, Frédéric; Auberger, Patrick; Galinsky, Ilene; DeAngelo, Daniel J.; Stone, Richard M.; Zhang, Yi; Perkins, Archibald; Shannon, Kevin; Hemann, Michael; Puissant, Alexandre (American Society of Hematology, 2017)
      Abnormal expression of the transcription factor EVI1 through chromosome 3q26 rearrangements has been implicated in the development of one of the most therapeutically challenging high-risk subtypes of acute myeloid leukemia ...