Browsing by Author "Tian, Ze"

Now showing items 1-6 of 6

    • Antitumor activity and mechanisms of action of total glycosides from aerial part of Cimicifuga dahurica targeted against hepatoma 

      Tian, Ze; Si, Jianyong; Chang, Qi; Zhou, Liang; Chen, Shilin; Xiao, Peigen; Wu, Erxi (BioMed Central, 2007)
      Background: Medicinal plant is a main source of cancer drug development. Some of the cycloartane triterpenoids isolated from the aerial part of Cimicifuga dahurica showed cytotoxicity in several cancer cell lines. It is ...

    • Cambogin is Preferentially Cytotoxic to Cells Expressing PDGFR 

      Tian, Ze; Shen, Jie; Wang, Fengfei; Xiao, Peigen; Yang, Junshan; Lei, Hetian; Kazlauskas, Andrius; Kohane, Isaac Samuel; Wu, Erxi (Public Library of Science, 2011)
      Platelet-derived growth factor receptors (PDGFRs) have been implicated in a wide array of human malignancies, including medulloblastoma (MB), the most common brain tumor of childhood. Although significant progress in MB ...

    • Comprehensive Dissection of PDGF-PDGFR Signaling Pathways in PDGFR Genetically Defined Cells 

      Wu, Erxi; Palmer, Nathan; Tian, Ze; Moseman, Annie P.; Galdzicki, Michal; Wang, Xuetao; Berger, Bonnie; Zhang, Hongbing; Kohane, Isaac Samuel (Public Library of Science, 2008)
      Despite the growing understanding of PDGF signaling, studies of PDGF function have encountered two major obstacles: the functional redundancy of PDGFRα and PDGFRβ in vitro and their distinct roles in vivo. Here we used ...

    • A Practical Platform for Blood Biomarker Study by Using Global Gene Expression Profiling of Peripheral Whole Blood 

      Tian, Ze; Palmer, Nathan; Schmid, Patrick; Yao, Hui; Galdzicki, Michal; Berger, Bonnie; Wu, Erxi; Kohane, Isaac Samuel (Public Library of Science, 2009)
      Background: Although microarray technology has become the most common method for studying global gene expression, a plethora of technical factors across the experiment contribute to the variable of genome gene expression ...

    • Pre-Clinical Drug Prioritization via Prognosis-Guided Genetic Interaction Networks 

      Xiong, Jianghui; Liu, Juan; Rayner, Simon; Tian, Ze; Li, Yinghui; Chen, Shanguang (Public Library of Science, 2010)
      The high rates of failure in oncology drug clinical trials highlight the problems of using pre-clinical data to predict the clinical effects of drugs. Patient population heterogeneity and unpredictable physiology complicate ...

    • Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes 

      Dada, Shirine; Wong, Masie; Law, Kenneth; Wu, Erxi; Dunussi-Joannopoulos, Kyri; Bluestone, Jeffrey; Fiorina, Paolo; Vergani, Andrea; Jurewicz, Mollie; Tian, Ze; Abdi, Reza; Guleria, Indira; Rodig, Scott J.; Sayegh, Mohamed Hassan (American Diabetes Association, 2008)
      OBJECTIVES—To investigate a B-cell–depleting strategy to reverse diabetes in naïve NOD mice. RESEARCH DESIGN AND METHODS—We targeted the CD22 receptor on B-cells of naïve NOD mice to deplete and reprogram B-cells to ...