Now showing items 1-16 of 16

    • A 44-year-old man with eye, kidney, and brain dysfunction 

      Vodopivec, Ivana; Oakley, Derek Hayden; Perugino, Cory Adam; Venna, Nagagopal; Hedley-Whyte, E. Tessa; Stone, John H (Wiley-Blackwell, 2016)
      Retinal vasculopathy with cerebral leukodystrophy (RVCL) is a rare, autosomal dominant condition caused by mutations of the three-prime repair exonuclease-1 (TREX1). The phenotypic expressions range from isolated retinal ...
    • Adult Onset Leukodystrophy with Neuroaxonal Spheroids: Clinical, Neuroimaging and Neuropathologic Observations 

      Freeman, Stefanie H.; Hyman, Bradley Theodore; Sims, Katherine; Hedley-Whyte, E. Tessa; Vossough, Arastoo; Frosch, Matthew P.; Schmahmann, Jeremy Dan (Wiley-Blackwell, 2009)
      Pigmented orthochromatic leukodystrophy (POLD) and Hereditary diffuse leukoencephalopathy with spheroids HDLS are two adult onset leukodystrophies with neuroaxonal spheroids presenting with prominent neurobehavioral, ...
    • Ataxia, Dementia, and Hypogonadotropism Caused by Disordered Ubiquitination 

      Margolin, David H.; Kousi, Maria; Chan, Yee-Ming; Lim, Elaine T.; Schmahmann, Jeremy Dan; Hadjivassiliou, Marios; Hall, Janet E.; Adam, Ibrahim; Dwyer, Andrew; Plummer, Lacey; Aldrin, Stephanie V.; O, Julia; Kirby, Andrew; Lage, Kasper; Milunsky, Aubrey; Milunsky, Jeff M.; Chan, Jennifer Ang; Hedley-Whyte, E. Tessa; Daly, Mark Joseph; Katsanis, Nicholas; Seminara, Stephanie Beth (New England Journal of Medicine (NEJM/MMS), 2013)
      In recent years, we have seen great advances in the elucidation of genetic causes of cerebellar ataxia, with newly identified genes regulating a wide spectrum of cellular functions, including intracellular signaling, tau ...
    • Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury 

      McKee, Ann C.; Cantu, Robert C.; Nowinski, Christopher J.; Hedley-Whyte, E. Tessa; Gavett, Brandon E.; Budson, Andrew E.; Santini, Veronica E.; Lee, Hyo-Soon; Kubilus, Caroline A.; Stern, Robert A. (Oxford University Press (OUP), 2009)
      Since the 1920s, it has been known that the repetitive brain trauma associated with boxing may produce a progressive neurological deterioration, originally termed “dementia pugilistica” and more recently, chronic traumatic ...
    • Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance. 

      Maxwell, M; Naber, S P; Wolfe, H J; Galanopoulos, T; Hedley-Whyte, E. Tessa; Black, Peter McLaren; Antoniades, H N (American Society for Clinical Investigation, 1990)
      The present studies investigated the expression of the two PDGF genes (c-sis/PDGF-2 and PDGF-1) and the PDGF-receptor b gene (PDGF-R) in 34 primary human astrocytomas. Northern blot analysis demonstrated the coexpression ...
    • Distribution of [1,2-3H]cholesterol in mouse brain after injection in the suckling period 

      Hedley-Whyte, E. Tessa (Rockefeller University Press, 1975)
      Glutaraldehyde-carbohydrazide polymer (GACH) was used to embed olfactory tracts, trapezoid body, and sciatic nerves of 9-, 10-, and 49- day old mice 2 h, 24 h, and 6 wk (respectively) after the intraperitoneal administration ...
    • Fine Structural Localization of Cholesterol-1,2-3h in Degenerating and Regenerating Mouse Sciatic Nerve 

      Rawlins, F. A.; Villegas, G. M.; Hedley-Whyte, E. Tessa; Uzman, B. G. (Rockefeller University Press, 1972)
      The localization of 3H-labeled cholesterol in nerves undergoing degeneration and regeneration was studied by radioautography at the electron microscope level. Two types of experiments were carried out: (a) Cholesterol-1,2-3H ...
    • Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of "Rebound" Revascularization as Mode of Escape 

      di Tomaso, E.; Snuderl, M.; Kamoun, W. S.; Duda, Dan Gabriel; Auluck, P. K.; Fazlollahi, L.; Andronesi, Ovidiu C; Frosch, Matthew P.; Wen, Patrick Yung Chih; Plotkin, Scott Randall; Hedley-Whyte, E. Tessa; Sorensen, A; Batchelor, Tracy Todd; Jain, Radhika (American Association for Cancer Research (AACR), 2011)
      Recurrent glioblastomas (rGBM) invariably relapse after initial response to anti-VEGF therapy. There are two prevailing hypotheses on how these tumors escape antiangiogenic therapy: switch to VEGF-independent angiogenic ...
    • Myelin: Dynamic or Stable? 

      Uzman, Betty G.; Hedley-Whyte, E. Tessa (Rockefeller University Press, 1968)
    • Nodular bilateral amygdala degeneration in demented individuals 

      Lain, Aurelio Hernandez; Lieberman, Andrew P.; Pfannl, Rolf; Hedley-Whyte, E. Tessa (Springer Nature, 2010)
      Among more than 2050 brains in our Alzheimer disease brain banks we came across three brains with well demarcated indurated white-yellow nodules in the amygdalas. Microscopically, these nodules were composed of numerous ...
    • Phylogenetic and epidemiologic evidence of multiyear incubation in human rabies 

      Boland, Torrey A.; McGuone, Declan; Jindal, Jenelle; Rocha, Marcelo; Cumming, Melissa; Rupprecht, Charles E.; Barbosa, Taciana Fernandes Souza; de Novaes Oliveira, Rafael; Chu, Catherine Jean; Cole, Andrew James; Kotait, Ivanete; Kuzmina, Natalia A.; Yager, Pamela A.; Kuzmin, Ivan V.; Hedley-Whyte, E. Tessa; Brown, Catherine M.; Rosenthal, Eric Scott (Wiley-Blackwell, 2014)
      Eight years after emigrating from Brazil, an otherwise healthy man developed rabies. An exposure prior to immigration was reported. Genetic analysis revealed a canine rabies virus variant found only in the patient’s home ...
    • Preservation of Neuronal Number Despite Age-Related Cortical Brain Atrophy in Elderly Subjects Without Alzheimer Disease 

      Freeman, Stefanie H.; Kandel, Ruth; Cruz, Luis; Rozkalne, Anete; Newell, Kathy; Frosch, Matthew P.; Hedley-Whyte, E. Tessa; Locascio, Joseph J; Lipsitz, Lewis Arnold; Hyman, Bradley Theodore (Oxford University Press (OUP), 2008)
      Cerebral volume loss has long been associated with normal aging but whether this is due to aging itself or to age-related diseases including incipient Alzheimer disease (AD) is uncertain. To understand the changes that ...
    • Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4 

      Deng, Han-Xiang; Klein, Christopher J; Yan, Jianhua; Shi, Yong; Wu, Yanhong; Fecto, Faisal; Yau, Hau-Jie; Yang, Yi; Zhai, Hong; Siddique, Nailah; Hedley-Whyte, E. Tessa; DeLong, Robert; Martina, Marco; Dyck, Peter J; Siddique, Teepu (Springer Nature, 2009)
      Scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC, also known as HMSN2C or Charcot-Marie-Tooth disease type 2C (CMT2C)) are phenotypically heterogeneous disorders ...
    • Sex-Linked Hereditary Bilateral Anophthalmos 

      Brunquell, Philip J.; Papale, John H.; Horton, Jonathan C.; Williams, Roger S.; Zgrabik, Michael J.; Albert, Daniel Myron; Hedley-Whyte, E. Tessa (American Medical Association (AMA), 1984)
      A 27-year-old man had X-linked true anophthalmos. No evidence of optic globe, nerves, or chiasm was found. Rudimentary structures suggesting optic tracts were present. Lateral geniculate nuclei were present but gliotic. ...
    • TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy 

      McKee, Ann C.; Gavett, Brandon E.; Stern, Robert A.; Nowinski, Christopher J.; Cantu, Robert C.; Kowall, Neil William; Perl, Daniel P.; Hedley-Whyte, E. Tessa; Price, Bruce Heimburger; Sullivan, Chris; Morin, Peter; Lee, Hyo-Soon; Kubilus, Caroline A.; Daneshvar, Daniel H.; Wulff, Megan; Budson, Andrew E. (Oxford University Press (OUP), 2010)
      Epidemiological evidence suggests that the incidence of amyotrophic lateral sclerosis is increased in association with head injury. Repetitive head injury is also associated with the development of chronic traumatic ...
    • Ultrastructural localization of glial fibrillary acidic protein in mouse cerebellum by immunoperoxidase labeling 

      Schachner, M.; Hedley-Whyte, E. Tessa; Hsu, D. W.; Schoonmaker, G.; Bignami, A. (Rockefeller University Press, 1977)
      Glial fibrillary acidic protein was localized at the electron microscope level in the cerebellum of adult mice by indirect immunoperoxidase histology. In confirmation of previous studies at the light microscope level, the ...