Now showing items 1-5 of 5

    • Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression 

      Sullivan, James P; Nahed, Brian Vala; Madden, M. W.; Oliveira, S. M.; Springer, S.; Bhere, Deepak; Chi, A. S.; Wakimoto, Hiroaki; Rothenberg, S. M.; Sequist, Lecia VanDam; Kapur, R.; Shah, Khalid A.; Iafrate, Anthony John; Curry, William Thomas; Loeffler, Jay Steven; Batchelor, Tracy Todd; Louis, David N.; Toner, Mehmet; Maheswaran, Shyamala; Haber, Daniel Arie (American Association for Cancer Research (AACR), 2014)
      Glioblastoma (GBM) is a highly aggressive brain cancer characterized by local invasion and angiogenic recruitment, yet metastatic dissemination is extremely rare. Here, we adapted a microfluidic device to deplete hematopoietic ...
    • Encapsulated stem cells for cancer therapy 

      Shah, Khalid (Landes Bioscience, 2013)
      Stem cells have inherent tumor‑trophic migratory properties and can serve as vehicles for delivering effective, targeted therapy to isolated tumors and metastatic disease, making them promising anti‑cancer agents. Encapsulation ...
    • Evaluating the Effect of Therapeutic Stem Cells on TRAIL Resistant and Sensitive Medulloblastomas 

      Nesterenko, Irina; Wanningen, Simone; Bagci-Onder, Tugba; Anderegg, Maarten; Shah, Khalid A. (Public Library of Science, 2012)
      Mesenchymal stem cells (MSC) are emerging as novel cell-based delivery agents; however, a thorough investigation addressing their therapeutic potential in medulloblastomas (MB) has not been explored to date. In this study, ...
    • A First-Generation Multi-Functional Cytokine for Simultaneous Optical Tracking and Tumor Therapy 

      Hingtgen, Shawn; Kasmieh, Randa; Elbayly, Elizabeth; Nesterenko, Irina; Figueiredo, Jose-Luiz; Dash, Rupesh; Sarkar, Devanand; Hall, David; Kozakov, Dima; Vajda, Sandor; Fisher, Paul B.; Shah, Khalid A. (Public Library of Science, 2012)
      Creating new molecules that simultaneously enhance tumor cell killing and permit diagnostic tracking is vital to overcoming the limitations rendering current therapeutic regimens for terminal cancers ineffective. Accordingly, ...
    • Targeting c-Met Receptor Overcomes TRAIL-Resistance in Brain Tumors 

      Du, Wanlu; Uslar, Liubov; Sevala, Sindhura; Shah, Khalid (Public Library of Science, 2014)
      Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) induced apoptosis specifically in tumor cells. However, with approximately half of all known tumor lines being resistant to TRAIL, the identification of TRAIL ...