Browsing by Author "Brigl, Manfred"
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The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions
Macho-Fernandez, Elodie; Brigl, Manfred (Frontiers Media S.A., 2015)Natural killer T (NKT) cells comprise a family of specialized T cells that recognize lipid antigens presented by CD1d. Based on their T cell receptor (TCR) usage and antigen specificities, CD1d-restricted NKT cells have ... -
Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells
Cohen, Nadia R.; Brennan, Patrick J.; Shay, Tal; Watts, Gerald F.; Brigl, Manfred; Kang, Joonsoo; Brenner, Michael B. (2013)Invariant natural killer T (iNKT) cells are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled iNKT cell gene expression during ontogeny ... -
Synthesis and Biological Activity of α-Galactosyl Ceramide KRN7000 and Galactosyl (α1→2) Galactosyl Ceramide
Veerapen, Natacha; Brigl, Manfred; Garg, Salil; Cerundolo, Vincenzo; Cox, Liam R.; Brenner, Michael Barry; Besra, Gurdyal S. (Elsevier Science Ltd, 2009)We herein report a faster and less cumbersome synthesis of the biologically attractive, α-galactosyl ceramide (α-GalCer), known as KRN7000, and its analogues. More importantly, the use of a silicon tethered intramolecular ...