Browsing by Author "Whitford, T"
Now showing items 1-12 of 12
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Abnormalities of middle longitudinal fascicle and disorganization in patients with schizophrenia
Asami, Takeshi; Saito, Yukiko; Whitford, Thomas; Makris, Nikos; Niznikiewicz, Margaret A.; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Elsevier BV, 2013)Introduction—The Middle Longitudinal Fascicle (MdLF) is a long association fiber connecting the superior temporal gyrus (STG) and temporal pole with the angular gyrus through the white matter of the STG, structures which ... -
Cerebral white matter abnormalities and their associations with negative but not positive symptoms of schizophrenia
Asami, Takeshi; Hyuk Lee, Sang; Bouix, Sylvain; Rathi, Yogesh; Whitford, Thomas; Niznikiewicz, Margaret A.; Nestor, Paul Gerard; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Elsevier BV, 2014)Although diffusion tensor imaging (DTI) studies have reported fractional anisotropy (FA) abnormalities in multiple white matter (WM) regions in schizophrenia, relationship between abnormal FA and negative symptoms has not ... -
Cingulum bundle integrity associated with delusions of control in schizophrenia: Preliminary evidence from diffusion-tensor tractography
Whitford, Thomas; Kubicki, Marek R.; Pelavin, Paula E.; Lucia, Diandra; Schneiderman, Jason S.; Pantelis, Christos; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2015)Background—Delusions of control are among the most distinctive and characteristic symptoms of schizophrenia. Several theories have been proposed that implicate aberrant communication between spatially disparate brain regions ... -
Corpus Callosum Abnormalities and Their Association with Psychotic Symptoms in Patients with Schizophrenia
Whitford, Thomas; Kubicki, Marek R.; Schneiderman, Jason S.; O, Lauren J.; King, Rebecca; Alvarado, Jorge L.; Khan, Usman; Markant, Douglas; Nestor, Paul Gerard; Niznikiewicz, Margaret A.; McCarley, Robert William; Westin, Carl-Fredrik; Shenton, Martha Elizabeth (Elsevier BV, 2010)Background—Whilst the neuroanatomical underpinnings of the functional brain disconnectivity observed in patients with schizophrenia remain elusive, white matter fiber bundles of the brain are a likely candidate given that ... -
Diffusion Tensor Imaging, Structural Connectivity, and Schizophrenia
Whitford, Thomas; Kubicki, Marek R.; Shenton, Martha E. (Hindawi Publishing Corporation, 2011)A fundamental tenet of the “disconnectivity” theories of schizophrenia is that the disorder is ultimately caused by abnormal communication between spatially disparate brain structures. Given that the white matter fasciculi ... -
Electrophysiological and diffusion tensor imaging evidence of delayed corollary discharges in patients with schizophrenia
Whitford, T; Mathalon, D. H.; Shenton, Martha Elizabeth; Roach, B. J.; Bammer, R.; Adcock, R. A.; Bouix, Sylvain; Kubicki, Marek R.; De Siebenthal, J.; Rausch, A. C.; Schneiderman, J. S.; Ford, J. M. (Cambridge University Press (CUP), 2010)Patients with schizophrenia (SZ) characteristically exhibit supranormal levels of cortical activity to self-induced sensory stimuli, ostensibly because of abnormalities in the neural signals (corollary discharges, CDs) ... -
Fiber geometry in the corpus callosum in schizophrenia: Evidence for transcallosal misconnection
Whitford, Thomas; Savadjiev, Peter; Kubicki, Marek R.; O, Lauren J.; Terry, Douglas P.; Bouix, Sylvain; Westin, Carl-Fredrik; Schneiderman, Jason S.; Bobrow, Laurel; Rausch, Andrew C.; Niznikiewicz, Margaret A.; Nestor, Paul Gerard; Pantelis, Christos; Wood, Stephen J.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2011)Background—Structural abnormalities in the callosal fibers connecting the heteromodal association areas of the prefrontal and temporoparietal cortices bilaterally have been suggested to play a role in the etiology of ... -
Localized abnormalities in the cingulum bundle in patients with schizophrenia: A Diffusion Tensor tractography study
Whitford, Thomas J.; Lee, Sun Woo; Oh, Jungsu S.; de Luis-Garcia, Rodrigo; Savadjiev, Peter; Alvarado, Jorge L.; Westin, Carl-Fredrik; Niznikiewicz, Margaret; Nestor, Paul G.; McCarley, Robert W.; Kubicki, Marek; Shenton, Martha E. (Elsevier, 2014)The cingulum bundle (CB) connects gray matter structures of the limbic system and as such has been implicated in the etiology of schizophrenia. There is growing evidence to suggest that the CB is actually comprised of a ... -
Longitudinal loss of gray matter volume in patients with first-episode schizophrenia: DARTEL automated analysis and ROI validation
Asami, Takeshi; Bouix, Sylvain; Whitford, Thomas; Shenton, Martha Elizabeth; Salisbury, Dean F.; McCarley, Robert William (Elsevier BV, 2012)Region of Interest (ROI) longitudinal studies have detected progressive gray matter (GM) volume reductions in patients with first-episode schizophrenia (FESZ). However, there are only a few longitudinal voxel-based morphometry ... -
Predicting inter-hemispheric transfer time from the diffusion properties of the corpus callosum in healthy individuals and schizophrenia patients: A combined ERP and DTI study
Whitford, Thomas; Kubicki, Marek R.; Ghorashi, Shahab; Schneiderman, Jason S.; Hawley, Kathryn J.; McCarley, Robert William; Shenton, Martha Elizabeth; Spencer, Kevin M. (Elsevier BV, 2011)Background—Several theories of schizophrenia have emphasized the role of aberrant neural timing in the etiology of the disease, possibly as a consequence of conduction delays caused by structural damage to the white-matter ... -
Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophrenia
Kubicki, Marek R.; Alvarado, Jorge L.; Westin, Carl-Fredrik; Tate, David F.; Markant, Douglas; Terry, Douglas P.; Whitford, Thomas; De Siebenthal, Julien; Bouix, Sylvain; McCarley, Robert William; Kikinis, Ron; Shenton, Martha Elizabeth (Elsevier BV, 2011)Background—Abnormalities within language-related anatomical structures have been associated with clinical symptoms and with language and memory deficits in schizophrenia. Recent studies suggest disruptions in functional ... -
Structural abnormalities in the cuneus associated with Herpes Simplex Virus (type 1) infection in people at ultra high risk of developing psychosis
Whitford, Thomas; Wood, Stephen J.; Yung, Alison; Cocchi, Luca; Berger, Gregor; Shenton, Martha Elizabeth; Kubicki, Marek R.; Phillips, Lisa; Velakoulis, Dennis; Yolken, Robert H.; Pantelis, Christos; McGorry, Patrick; Amminger, G. Paul (Elsevier BV, 2012)It has been suggested that some cases of schizophrenia may be caused by an interaction between physiological risk factors and exposure to certain neurotropic infectious agents such as Herpes Simplex Virus type 1 (HSV1). ...