Browsing by Author "Chavez, Alejandro"

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    • Comparative Analysis of Cas9 Activators Across Multiple Species 

      Chavez, Alejandro; Tuttle, Marcelle; Pruitt, Benjamin W; Ewen-Campen, Ben; Chari, Raj; Ter-Ovanesyan, Dmitry; Haque, Sabina J; Cecchi, Ryan J; Kowal, Emma J K; Buchthal, Joanna; Housden, Benjamin E; Perrimon, Norbert; Collins, James J; Church, George (2016)
      Several groups have generated programmable transcription factors based on the versatile Cas9 protein, yet their relative potency and effectiveness across various cell types and species remain unexplored. Here, we compare ...

    • Safeguarding CRISPR-Cas9 gene drives in yeast 

      DiCarlo, James E.; Chavez, Alejandro; Dietz, Sven L.; Esvelt, Kevin M.; Church, George M. (2015)
      RNA-guided gene drives capable of spreading genomic alterations made in laboratory organisms through wild populations in an inheritable way could be used to control populations of organisms that cause environmental and ...