Browsing by Author "He, Zhigang"

Now showing items 1-5 of 5

    • B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS 

      O’Donovan, Kevin J.; Ma, Kaijie; Guo, Hengchang; Wang, Chen; Sun, Fang; Han, Seung Baek; Kim, Hyukmin; Wong, Jamie K.; Charron, Jean; Zou, Hongyan; Son, Young-Jin; He, Zhigang; Zhong, Jian (The Rockefeller University Press, 2014)
      Activation of intrinsic growth programs that promote developmental axon growth may also facilitate axon regeneration in injured adult neurons. Here, we demonstrate that conditional activation of B-RAF kinase alone in mouse ...

    • The Brain Metabolome of Male Rats across the Lifespan 

      Zheng, Xiaojiao; Chen, Tianlu; Zhao, Aihua; Wang, Xiaoyan; Xie, Guoxiang; Huang, Fengjie; Liu, Jiajian; Zhao, Qing; Wang, Shouli; Wang, Chongchong; Zhou, Mingmei; Panee, Jun; He, Zhigang; Jia, Wei (Nature Publishing Group, 2016)
      Comprehensive and accurate characterization of brain metabolome is fundamental to brain science, but has been hindered by technical limitations. We profiled the brain metabolome in male Wistar rats at different ages (day ...

    • In Vivo Two-Photon Imaging of Axonal Dieback, Blood Flow, and Calcium Influx with Methylprednisolone Therapy after Spinal Cord Injury 

      Tang, Peifu; Zhang, Yiling; Chen, Chao; Ji, Xinran; Ju, Furong; Liu, Xingyu; Gan, Wen-Biao; He, Zhigang; Zhang, Shengxiang; Li, Wei; Zhang, Lihai (Nature Publishing Group, 2015)
      Severe spinal cord injury (SCI) can cause neurological dysfunction and paralysis. However, the early dynamic changes of neurons and their surrounding environment after SCI are poorly understood. Although methylprednisolone ...

    • Intrinsic control of axon regeneration 

      He, Zhigang (Editorial Department of Journal of Biomedical Research, 2010)
      Spinal cord injury disrupts the connections between the brain and spinal cord, often resulting in the loss of sensory and motor function below the lesion site. The most important reason for such permanent functional deficits ...

    • Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3 

      Jin, Duo; Liu, Yuanyuan; Sun, Fang; Wang, Xuhua; Liu, Xuefeng; He, Zhigang (Nature Pub. Group, 2015)
      The limited rewiring of the corticospinal tract (CST) only partially compensates the lost functions after stroke, brain trauma and spinal cord injury. Therefore it is important to develop new therapies to enhance the ...