Now showing items 1-20 of 24

    • Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment 

      Klattenhoff, Carla A.; Scheuermann, Johanna C.; Surface, Lauren E.; Bradley, Robert K.; Fields, Paul A.; Steinhauser, Matthew L.; Ding, Huiming; Butty, Vincent L.; Torrey, Lillian; Haas, Simon; Abo, Ryan; Tabebordbar, Mohammadsharif; Lee, Richard Theodore; Burge, Christopher B.; Boyer, Laurie A. (Elsevier BV, 2013)
      Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner, yet little is known about their roles in lineage commitment. Here, we identified Braveheart (Bvht), a heart-associated lncRNA in mouse. ...
    • Cardiac Stem Cell Therapy and the Promise of Heart Regeneration 

      Garbern, Jessica; Lee, Richard Theodore (Elsevier BV, 2013)
      Stem cell therapy for cardiac disease is an exciting but highly controversial research area. Strategies such as cell transplantation and reprogramming have demonstrated both intriguing and sobering results. Yet as clinical ...
    • Common Genetic Variation at the IL1RL1 Locus Regulates IL-33/ST2 Signaling 

      Ho, Jennifer E.; Chen, Wei-Yu; Chen, Ming-Huei; Larson, Martin G.; McCabe, Elizabeth L.; Cheng, Susan; Ghorbani, Anahita; Coglianese, Erin; Emilsson, Valur; Johnson, Andrew D.; Walter, Stefan; Franceschini, Nora; O'Donnell, Christopher Joseph; Dehghan, Abbas; Lu, Chen; Levy, Daniel; Newton-Cheh, Christopher Holmes; Lin, Honghuang; Felix, Janine F.; Schreiter, Eric R.; Vasan, Ramachandran S.; Januzzi, James Louis; Lee, Richard Theodore; Wang, Thomas (American Society for Clinical Investigation, 2013)
      The suppression of tumorigenicity 2/IL-33 (ST2/IL-33) pathway has been implicated in several immune and inflammatory diseases. ST2 is produced as 2 isoforms. The membrane-bound isoform (ST2L) induces an immune response ...
    • Cystatin C deficiency in human atherosclerosis and aortic aneurysms 

      Shi, Guo-Ping; Sukhova, Galina K.; Grubb, Anders; Ducharme, Anique; Rhode, Luis H.; Lee, Richard Theodore; Ridker, Paul M.; Libby, Peter; Chapman, Harold A. (American Society for Clinical Investigation, 1999)
      The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves breakdown of the elastic laminae. Elastolytic cysteine proteases, including cathepsins S and K, are overexpressed at sites of arterial elastin ...
    • Delivering Heparin-Binding Insulin-Like Growth Factor 1 with Self-Assembling Peptide Hydrogels 

      Florine, Emily M.; Miller, Rachel E.; Liebesny, Paul H.; Mroszczyk, Keri A.; Lee, Richard Theodore; Patwari, Parth; Grodzinsky, Alan J. (Mary Ann Liebert Inc, 2015)
      Heparin-binding insulin-like growth factor 1 (HB-IGF-1) is a fusion protein of IGF-1 with the HB domain of heparin-binding epidermal growth factor-like growth factor. A single dose of HB-IGF-1 has been shown to bind ...
    • Diabetes regulates fructose absorption through thioredoxin-interacting protein 

      Dotimas, James R; Lee, Austin W; Schmider, Angela B; Carroll, Shannon H; Shah, Anu; Bilen, Julide; Elliott, Kayla R; Myers, Ronald B; Soberman, Roy J; Yoshioka, Jun; Lee, Richard T (eLife Sciences Publications, Ltd, 2016)
      Metabolic studies suggest that the absorptive capacity of the small intestine for fructose is limited, though the molecular mechanisms controlling this process remain unknown. Here we demonstrate that thioredoxin-interacting ...
    • Echocardiography-derived left ventricular end-systolic regional wall stress and matrix remodeling after experimental myocardial infarction 

      Rohde, Luis E; Aikawa, Masanori; Cheng, George Z; Sukhova, Galina K.; Solomon, Scott David; Libby, Peter; Pfeffer, Janice; Pfeffer, Marc Alan; Lee, Richard Theodore (Elsevier BV, 1999)
      OBJECTIVES We tested the hypothesis that regional end-systolic left ventricular (ESLV) wall stress is associated with extracellular matrix remodeling activity after myocardial infarction (MI). BACKGROUND Increased ...
    • An Engineered Bivalent Neuregulin Protects Against Doxorubicin-Induced Cardiotoxicity With Reduced Proneoplastic Potential 

      Jay, S. M.; Murthy, A. C.; Hawkins, Jessica Faye; Wortzel, Joshua Ross; Steinhauser, Matthew L.; Alvarez, L. M.; Gannon, J.; MacRae, Calum Archibald; Griffith, L. G.; Lee, Richard Theodore (Ovid Technologies (Wolters Kluwer Health), 2013)
      Background—Doxorubicin (DOXO) is an effective anthracycline chemotherapeutic, but its use is limited by cumulative dose-dependent cardiotoxicity. Neuregulin-1β is an ErbB receptor family ligand that is effective against ...
    • Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy 

      Loffredo, Francesco; Steinhauser, Matthew L.; Jay, Steven M.; Gannon, Joseph; Pancoast, James R.; Yalamanchi, Pratyusha; Sinha, Manisha; Dall’Osso, Claudia; Khong, Danika Mei Po; Shadrach, J; Miller, Christine; Singer, Britta S.; Stewart, Alex; Psychogios, Nikolaos; Gerszten, Robert Edgardo; Hartigan, Adam J.; Kim, Mi-Jeong; Serwold, Thomas Francis; Wagers, Amy Jo; Lee, Richard Theodore (Elsevier BV, 2013)
      The most common form of heart failure occurs with normal systolic function and often involves cardiac hypertrophy in the elderly. To clarify the biological mechanisms that drive cardiac hypertrophy in aging, we tested ...
    • Interleukin-33 Primes Mast Cells for Activation by IgG Immune Complexes 

      Kaieda, Shinjiro; Wang, Jun-Xia; Shnayder, Ruslan; Fishgal, Nadia; Hei, Hillary; Lee, Richard Theodore; Stevens, Richard Leslie; Nigrovic, Peter Andrija (Public Library of Science, 2012)
      Mast cells (MCs) are heterogeneous cells whose phenotype is modulated by signals received from the local microenvironment. Recent studies have identified the mesenchymal-derived cytokine IL-33 as a potent direct activator ...
    • Microbead-based biomimetic synthetic neighbors enhance survival and function of rat pancreatic β-cells 

      Li, Wei; Lee, Samuel; Ma, Minglin; Kim, Soo Min; Guye, Patrick; Pancoast, James R.; Anderson, Daniel G.; Weiss, Ron; Lee, Richard T.; Hammond, Paula T. (Nature Publishing Group, 2013)
      Diabetes is caused by the loss or dysfunction of insulin-secreting β-cells in the pancreas. β-cells reduce their mass and lose insulin-producing ability in vitro, likely due to insufficient cell-cell and cell-extracellular ...
    • Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration 

      Zhao, Long; Borikova, Asya; Ben-Yair, Raz; Guner-Ataman, Burcu; MacRae, Calum Archibald; Lee, Richard Theodore; Burns, Charles Geoffrey; Burns, Caroline Erter (Proceedings of the National Academy of Sciences, 2014)
      The human heart’s failure to replace ischemia-damaged myocardium with regenerated muscle contributes significantly to the worldwide morbidity and mortality associated with coronary artery disease. Remarkably, certain ...
    • A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity 

      Qiao, Shuxi; Dennis, Michael; Song, Xiufeng; Vadysirisack, Douangsone D.; Salunke, Devika; Nash, Zachary; Yang, Zhifen; Liesa, Marc; Yoshioka, Jun; Matsuzawa, Shu-Ichi; Shirihai, Orian S.; Lee, Richard T.; Reed, John C.; Ellisen, Leif W. (Nature Pub. Group, 2015)
      Macroautophagy (autophagy) is a critical cellular stress response; however, the signal transduction pathways controlling autophagy induction in response to stress are poorly understood. Here we reveal a new mechanism of ...
    • Regeneration of the heart 

      Steinhauser, Matthew L.; Lee, Richard Theodore (WILEY-VCH Verlag, 2011)
      The death of cardiac myocytes diminishes the heart's pump function and is a major cause of heart failure, one of the dominant causes of death worldwide. Other than transplantation, there are no therapies that directly ...
    • Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle 

      Sinha, M; Jang, Y. C.; Oh, Juhyun; Khong, Danika Mei Po; Wu, Elizabeth Y; Manohar, Rohan; Miller, Christine; Regalado, Samuel G.; Loffredo, F; Pancoast, James R.; Hirshman, Michael F; Lebowitz, Jessica; Shadrach, Jennifer; Cerletti, Massimiliano; Kim, Mi Jeong; Serwold, Thomas Francis; Goodyear, Laurie Joy; Rosner, Bernard Alfred; Lee, Richard Theodore; Wagers, Amy Jo (American Association for the Advancement of Science (AAAS), 2014)
      Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by exposure to a young circulation, suggesting that young blood contains humoral “rejuvenating” factors that can restore regenerative ...
    • A Sensitive Chemotaxis Assay Using a Novel Microfluidic Device 

      Zhang, Chen; Jang, Sunyoung; Amadi, Ovid C.; Shimizu, Koichi; Lee, Richard T.; Mitchell, Richard N. (Hindawi Publishing Corporation, 2013)
      Existing chemotaxis assays do not generate stable chemotactic gradients and thus—over time—functionally measure only nonspecific random motion (chemokinesis). In comparison, microfluidic technology has the capacity to ...
    • Soluble CD40 Ligand Levels Indicate Lipid Accumulation in Carotid Atheroma: An In Vivo Study with High-Resolution MRI 

      Blake, Gavin J.; Ostfeld, Robert J.; Yucel, Ergin; Varo, Nerea; Schönbeck, Uwe; Blake, Michael; Gerhard, Marie; Ridker, Paul M.; Libby, Peter; Lee, Richard Theodore (American Heart Association, 2003)
      Objective. The CD40/CD40 ligand pathway mediates inflammatory processes important in atherogenesis and the formation of the intraplaque lipid pool. We tested the hypothesis that plasma levels of soluble CD40 ligand are ...
    • Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction 

      Ducharme, Anique; Frantz, Stefan; Aikawa, Masanori; Rabkin, Elena; Lindsey, Merry; Rohde, Luis E.; Schoen, Frederick Jack; Kelly, Ralph A.; Werb, Zena; Libby, Peter; Lee, Richard Theodore (American Society for Clinical Investigation, 2000)
      Matrix metalloproteinase-9 (MMP-9) is prominently overexpressed after myocardial infarction (MI). We tested the hypothesis that mice with targeted deletion of MMP9 have less left ventricular (LV) dilation after experimental ...
    • Targeted Delivery to Cartilage Is Critical for In Vivo Efficacy of Insulin-like Growth Factor 1 in a Rat Model of Osteoarthritis 

      Loffredo, Francesco; Pancoast, JR; Cai, Lei; Vannelli, Todd; Dong, Jesse Z.; Lee, Richard Theodore; Patwari, Parth (Wiley-Blackwell, 2014)
      Objective: Acute articular injuries lead to an increased risk of progressive joint damage and osteoarthritis (OA), and no therapies are currently available to repair or protect the injured joint tissue. Intraarticular ...
    • Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (βTCP) via Fusion to a High Affinity, Multimeric βTCP-Binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors 

      Alvarez, Luis M.; Rivera, Jaime J.; Stockdale, Linda; Saini, Sunil; Lee, Richard T.; Griffith, Linda G. (Public Library of Science, 2015)
      Transplantation of freshly-aspirated autologous bone marrow, together with a scaffold, is a promising clinical alternative to harvest and transplantation of autologous bone for treatment of large defects. However, survival ...