Browsing by Author "Hamblin, Michael"
Now showing items 1-20 of 23
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Antimicrobial and Efflux Pump Inhibitory Activity of Caffeoylquinic Acids from Artemisia absinthium Against Gram-Positive Pathogenic Bacteria
Fiamegos, Yiannis C.; Kastritis, Panagiotis L.; Exarchou, Vassiliki; Han, Haley; Bonvin, Alexandre M. J. J.; Vervoort, Jacques; Lewis, Kim; Hamblin, Michael; Tegos, George (Public Library of Science, 2011)Background: Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated ... -
Can biowarfare agents be defeated with light?
Vatansever, Fatma; Ferraresi, Cleber; de Sousa, Marcelo Victor Pires; Yin, Rui; Rineh, Ardeshir; Sharma, Sulbha K; Hamblin, Michael R (Landes Bioscience, 2013)Biological warfare and bioterrorism is an unpleasant fact of 21st century life. Highly infectious and profoundly virulent diseases may be caused in combat personnel or in civilian populations by the appropriate dissemination ... -
Can osteoarthritis be treated with light?
Hamblin, Michael R (BioMed Central, 2013)Osteoarthritis is becoming more problematic as the population ages. Recent reports suggest that the benefit of anti-inflammatory drugs is unimpressive and the incidence of side effects is worrying. Low-level laser (light) ... -
Concepts and Principles of Photodynamic Therapy as an Alternative Antifungal Discovery Platform
Dai, Tianhong; Fuchs, Beth B.; Coleman, Jeffrey James; Prates, Renato A.; Astrakas, Christos; St. Denis, Tyler G.; Ribeiro, Martha S.; Mylonakis, Eleftherios; Hamblin, Michael; Tegos, George (Frontiers Research Foundation, 2012)Opportunistic fungal pathogens may cause superficial or serious invasive infections, especially in immunocompromised and debilitated patients. Invasive mycoses represent an exponentially growing threat for human health due ... -
Efficacy and Safety of a Low-level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-controlled, Double-blind Study
Jimenez, Joaquin J.; Wikramanayake, Tongyu C.; Bergfeld, Wilma; Hordinsky, Maria; Hickman, Janet G.; Hamblin, Michael R.; Schachner, Lawrence A. (Springer International Publishing, 2014)Significance Male and female pattern hair loss are common, chronic dermatologic disorders with limited therapeutic options. In recent years, a number of commercial devices using low-level laser therapy have been promoted, ... -
Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth
Hamrahi, Victoria; Hamblin, Michael; Jung, Walter; Benjamin, John B.; Paul, Kasie W.; Fischman, Alan J.; Tompkins, Ronald Gary; Carter, Edward Albert (Hindawi Publishing Corporation, 2012)Sepsis remains the major cause of death in patients with major burn injuries. In the present investigation we evaluated the interaction between burn injuries of varying severity and preexisting distant infection. We used ... -
Healing of perforating rat corneal incisions closed with photodynamic laser-activated tissue glue
Khadem, John; Martino, Michael; Anatelli, Florencia; Dana, Reza; Hamblin, Michael (Wiley-Blackwell, 2004)Background and Objectives Laser-activated photodynamic biologic tissue glues may be useful for closing incisions in ophthalmology. We report on the use of two such preparations to close perforating corneal incisions in ... -
Human Platelet-Rich Plasma- and Extracellular Matrix-Derived Peptides Promote Impaired Cutaneous Wound Healing In Vivo
Demidova-Rice, Tatiana; Wolf, Lindsey; Deckenback, Jeffry; Hamblin, Michael; Herman, Ira M. (Public Library of Science, 2012)Previous work in our laboratory has described several pro-angiogenic short peptides derived from endothelial extracellular matrices degraded by bacterial collagenase. Here we tested whether these peptides could stimulate ... -
Involvement of Skeletal Muscle Gene Regulatory Network in Susceptibility to Wound Infection Following Trauma
Apidianakis, Yiorgos; Mindrinos, Michael N.; Xiao, Wenzhong; Tegos, George; Papisov, Mikhail Ivanovich; Hamblin, Michael; Davis, Ronald W.; Tompkins, Ronald Gary; Rahme, Laurence G. (Public Library of Science, 2007)Despite recent advances in our understanding the pathophysiology of trauma, the basis of the predisposition of trauma patients to infection remains unclear. A Drosophila melanogaster/Pseudomonas aeruginosa injury and ... -
Low-level laser therapy for spinal cord injury in rats: effects of polarization
Ando, Takahiro; Sato, Shunichi; Kobayashi, Hiroaki; Nawashiro, Hiroshi; Ashida, Hiroshi; Hamblin, Michael R.; Obara, Minoru (Society of Photo-Optical Instrumentation Engineers, 2013)Abstract. The effects of laser polarization on the efficacy of near-infrared low-level laser therapy for spinal cord injury (SCI) are presented. Rat spinal cords were injured with a weight-drop device, and the lesion sites ... -
Low-level light in combination with metabolic modulators for effective therapy of injured brain
Dong, Tingting; Zhang, Qi; Hamblin, Michael; Wu, Mel (Nature Publishing Group, 2015)Stem cell technology has facilitated the development of human cell culture models of disease that can be used to study pathogenesis and test therapeutic candidates. These models hold particular promise for complex neurological ... -
Microbial Efflux Systems and Inhibitors: Approaches to Drug Discovery and the Challenge of Clinical Implementation
Kourtesi, Christina; Ball, Anthony R; Huang, Ying-Ying; Jachak, Sanjay M; Vera, D Mariano A; Khondkar, Proma; Gibbons, Simon; Hamblin, Michael; Tegos, George (Bentham Open, 2013)Conventional antimicrobials are increasingly ineffective due to the emergence of multidrug-resistance among pathogenic microorganisms. The need to overcome these deficiencies has triggered exploration for novel and ... -
Papain gel containing methylene blue for simultaneous caries removal and antimicrobial photoinactivation against Streptococcus mutans biofilms
Silva Jr., Zenildo Santos; Huang, Ying-Ying; de Freitas, Lucas Freitas; França, Cristiane Miranda; Botta, Sergio Brossi; Ana, Patrícia Aparecida; Mesquita-Ferrari, Raquel Agnelli; Santos Fernandes, Kristianne Porta; Deana, Alessandro; Lima Leal, Cintia Raquel; Prates, Renato Araujo; Hamblin, Michael R.; Bussadori, Sandra Kalil (Nature Publishing Group, 2016)This study intended to evaluate the effects of a papain-gel with a red-light absorbing pigment (methylene blue – MB) to mediate photodynamic therapy (PDT) against Streptococcus mutans biofilms. The PapaMBlue was compared ... -
Photobiomodulation (blue and green light) encourages osteoblastic-differentiation of human adipose-derived stem cells: role of intracellular calcium and light-gated ion channels
Wang, Yuguang; Huang, Ying-Ying; Wang, Yong; Lyu, Peijun; Hamblin, Michael R. (Nature Publishing Group, 2016)Human adipose-derived stem cells (hASCs) have the potential to differentiate into several different cell types including osteoblasts. Photobiomodulation (PBM) or low level laser therapy (LLLT) using red or near-infrared ... -
Photochemical activation of TRPA1 channels in neurons and animals
Kokel, David; Cheung, Chung Yan J.; Mills, Robert; Coutinho-Budd, Jaeda; Huang, Liyi; Setola, Vincent; Sprague, Jared; Jin, Shan; Jin, Youngnam N.; Huang, Xi-Ping; Bruni, Giancarlo; Woolf, Clifford; Roth, Bryan L.; Hamblin, Michael R; Zylka, Mark J.; Milan, David J.; Peterson, Randall T. (2013)Optogenetics is a powerful research tool because it enables high-resolution optical control of neuronal activity. However, current optogenetic approaches are limited to transgenic systems expressing microbial opsins and ... -
Photodynamic and Antibiotic Therapy Impair the Pathogenesis of Enterococcus faecium in a Whole Animal Insect Model
Chibebe, José, Jr.; Fuchs, Beth B.; Sabino, Caetano P.; Junqueira, Juliana C.; Jorge, Antonio O. C.; Ribeiro, Martha S.; Rice, Louis B.; Gilmore, Michael S.; Tegos, George; Hamblin, Michael; Mylonakis, Eleftherios (Public Library of Science, 2013)Enterococcus faecium has emerged as one of the most important pathogens in healthcare-associated infections worldwide due to its intrinsic and acquired resistance to many antibiotics, including vancomycin. Antimicrobial ... -
Photodynamic Therapy Can Induce a Protective Innate Immune Response against Murine Bacterial Arthritis via Neutrophil Accumulation
Tanaka, Masamitsu; Mroz, Pawel A.; Dai, Tianhong; Huang, Liyi; Morimoto, Yuji; Kinoshita, Manabu; Yoshihara, Yasuo; Nemoto, Koichi; Shinomiya, Nariyoshi; Seki, Suhji; Hamblin, Michael (Public Library of Science, 2012)Background: Local microbial infections induced by multiple-drug-resistant bacteria in the orthopedic field can be intractable, therefore development of new therapeutic modalities is needed. Photodynamic therapy (PDT) is a ... -
Photodynamic Therapy of Tumors Can Lead to Development of Systemic Antigen-Specific Immune Response
Mroz, Pawel A.; Szokalska, Angelika; Wu, Mei X.; Hamblin, Michael (Public Library of Science, 2010)Background: The mechanism by which the immune system can effectively recognize and destroy tumors is dependent on recognition of tumor antigens. The molecular identity of a number of these antigens has recently been ... -
Photodynamic therapy plus regulatory T-cell depletion produces immunity against a mouse tumour that expresses a self-antigen
Reginato, E; Mroz, P; Chung, H; Kawakubo, M; Wolf, P; Hamblin, M R (Nature Publishing Group, 2013)Background: Photodynamic therapy (PDT) can lead to development of antigen-specific immune response and PDT-mediated immunity can be potentiated by T regulatory cell (Treg) depletion. We investigated whether the combination ... -
Psychological Benefits 2 and 4 weeks After a Single Treatment with Near Infrared Light to the Forehead: A Pilot Study of 10 Patients with Major Depression and Anxiety
Schiffer, Fredric; Johnston, Andrea L; Ravichandran, Caitlin Thomas; Polcari, Ann; Teicher, Martin Hersch; Webb, Robert H.; Hamblin, Michael (BioMed Central, 2009)Background: Many studies have reported beneficial effects from the application of near-infrared (NIR) light photobiomodulation (PBM) to the body, and one group has reported beneficial effects applying it to the brain in ...