Browsing by Author "Hamblin, Michael"
Now showing items 1-20 of 42
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Antimicrobial and Efflux Pump Inhibitory Activity of Caffeoylquinic Acids from Artemisia absinthium Against Gram-Positive Pathogenic Bacteria
Fiamegos, Yiannis C.; Kastritis, Panagiotis L.; Exarchou, Vassiliki; Han, Haley; Bonvin, Alexandre M. J. J.; Vervoort, Jacques; Lewis, Kim; Hamblin, Michael; Tegos, George (Public Library of Science, 2011)Background: Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated ... -
Antimicrobial Photodynamic Inactivation Inhibits Candida albicans Virulence Factors and ReducesIn VivoPathogenicity
Kato, Ilka Tiemy; Prates, Renato Araujo; Sabino, Caetano Padial; Tegos, George P.; Mylonakis, Eleftherios; Ribeiro, Martha Simões; Hamblin, Michael; Fuchs, Beth Burgwyn (American Society for Microbiology, 2012-11-05)The objective of this study was to evaluate whether Candida albicans exhibits altered pathogenicity characteristics following sublethal antimicrobial photodynamic inactivation (APDI) and if such alterations are maintained ... -
Bacteriophages and Phage-Inspired Nanocarriers for Targeted Delivery of Therapeutic Cargos
Karimi, Mahdi; Mirshekari, Hamed; Moosavi Basri, Seyed Masoud; Bahrami, Sajad; Moghoofei, Mohsen; Hamblin, Michael (Elsevier BV, 2016-11)The main goal of drug delivery systems is to target therapeutic cargoes to desired cells and to ensure their efficient uptake. Recently a number of studies have focused on designing bio-inspired nanocarriers, such as ... -
Biodistribution of Charged 17.1A Photoimmunoconjugates in a Murine Model of Hepatic Metastasis of Colorectal Cancer
Governatore, M Del; Rizvi, I; Hasan, T; Hamblin, Michael (Springer Nature, 2000-12) -
Biodistribution of Charged F(ab')2 Photoimmunoconjugates in a Xenograft Model of Ovarian Cancer
Duska, LR; Bamberg, MP; Hasan, T; Hamblin, Michael (Springer Nature, 1997-03)The effect of charge modification of photoimmunoconjugates (PICs) on their biodistribution in a xenograft model of ovarian cancer was investigated. Chlorine(e6) c(e6) was attached site specifically to the F(ab')(2) fragment ... -
Broad-Spectrum Antimicrobial Effects of Photocatalysis Using Titanium Dioxide Nanoparticles Are Strongly Potentiated by Addition of Potassium Iodide
Huang, Ying-Ying; Choi, Hwanjun; Kushida, Yu; Bhayana, Brijesh; Wang, Yuguang; Hamblin, Michael (American Society for Microbiology, 2016-07-05)Photocatalysis describes the excitation of titanium dioxide nanoparticles (a wide-band gap semiconductor) by UVA light to produce reactive oxygen species (ROS) that can destroy many organic molecules. This photocatalysis ... -
Can biowarfare agents be defeated with light?
Vatansever, Fatma; Ferraresi, Cleber; de Sousa, Marcelo Victor Pires; Yin, Rui; Rineh, Ardeshir; Sharma, Sulbha K; Hamblin, Michael R (Landes Bioscience, 2013)Biological warfare and bioterrorism is an unpleasant fact of 21st century life. Highly infectious and profoundly virulent diseases may be caused in combat personnel or in civilian populations by the appropriate dissemination ... -
Can osteoarthritis be treated with light?
Hamblin, Michael R (BioMed Central, 2013)Osteoarthritis is becoming more problematic as the population ages. Recent reports suggest that the benefit of anti-inflammatory drugs is unimpressive and the incidence of side effects is worrying. Low-level laser (light) ... -
Characterization of a Conjugate between Rose Bengal and Chitosan for Targeted Antibiofilm and Tissue Stabilization Effects as a Potential Treatment of Infected Dentin
Shrestha, Annie; Kishen, Anil; Hamblin, Michael (American Society for Microbiology, 2012-07-09)Bacterial biofilms and dentin structural changes are some of the major challenges in the management of infected dentin tissue. This study characterized a photosensitizer-conjugated chitosan with enhanced photodynamic ... -
Concepts and Principles of Photodynamic Therapy as an Alternative Antifungal Discovery Platform
Dai, Tianhong; Fuchs, Beth B.; Coleman, Jeffrey James; Prates, Renato A.; Astrakas, Christos; St. Denis, Tyler G.; Ribeiro, Martha S.; Mylonakis, Eleftherios; Hamblin, Michael; Tegos, George (Frontiers Research Foundation, 2012)Opportunistic fungal pathogens may cause superficial or serious invasive infections, especially in immunocompromised and debilitated patients. Invasive mycoses represent an exponentially growing threat for human health due ... -
Effect of Cell-Photosensitizer Binding and Cell Density on Microbial Photoinactivation
Demidova, T. N.; Hamblin, Michael; demidova (American Society for Microbiology, 2005-05-25)Photodynamic therapy involves the use of nontoxic dyes called photosensitizers and visible light to produce reactive oxygen species and cell killing. It is being studied as an alternative method of killing pathogens in ... -
Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed-Onset Muscle Soreness
Ferraresi, Cleber; Bertucci, Danilo; Schiavinato, Josiane; Reiff, Rodrigo; Araújo, Amélia; Panepucci, Rodrigo; Matheucci, Euclides; Cunha, Anderson Ferreira; Arakelian, Vivian Maria; Parizotto, Nivaldo; Bagnato, Vanderlei; Hamblin, Michael (2016-10)Objective The aim of this study was to verify how a pair of monozygotic twins would respond to light-emitting diode therapy (LEDT) or placebo combined with a strength-training program during 12 weeks.Design This case-control ... -
Efficacy and Safety of a Low-level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-controlled, Double-blind Study
Jimenez, Joaquin J.; Wikramanayake, Tongyu C.; Bergfeld, Wilma; Hordinsky, Maria; Hickman, Janet G.; Hamblin, Michael R.; Schachner, Lawrence A. (Springer International Publishing, 2014)Significance Male and female pattern hair loss are common, chronic dermatologic disorders with limited therapeutic options. In recent years, a number of commercial devices using low-level laser therapy have been promoted, ... -
Eradication of Multidrug-Resistant Pseudomonas Biofilm With Pulsed Electric Fields
Khan, Saiqa I.; Blumrosen, Gaddi; Vecchio, Daniela; Golberg, Alexander; Hamblin, Michael; McCormack, Michael; Yarmush, Martin; Austen, William (Wiley, 2015-09-09)Biofilm formation is a significant problem, accounting for over eighty percent of microbial infections in the body. Biofilm eradication is problematic due to increased resistance to antibiotics and antimicrobials as compared ... -
Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth
Hamrahi, Victoria; Hamblin, Michael; Jung, Walter; Benjamin, John B.; Paul, Kasie W.; Fischman, Alan J.; Tompkins, Ronald Gary; Carter, Edward Albert (Hindawi Publishing Corporation, 2012)Sepsis remains the major cause of death in patients with major burn injuries. In the present investigation we evaluated the interaction between burn injuries of varying severity and preexisting distant infection. We used ... -
A Green Fluorescent Protein-Expressing Murine Tumour but Not Its Wild-Type Counterpart Is Cured by Photodynamic Therapy
Castano, A P; Liu, Q; Hamblin, Michael (Springer Nature, 2006-01-17)The ideal cancer treatment should both destroy the primary tumour and at the same time educate the immune system to recognise the tumour as foreign so that distant metastases will also be eradicated. Photodynamic therapy ... -
Healing of perforating rat corneal incisions closed with photodynamic laser-activated tissue glue
Khadem, John; Martino, Michael; Anatelli, Florencia; Dana, Reza; Hamblin, Michael (Wiley-Blackwell, 2004)Background and Objectives Laser-activated photodynamic biologic tissue glues may be useful for closing incisions in ophthalmology. We report on the use of two such preparations to close perforating corneal incisions in ... -
Helicobacter pylori Accumulates Photoactive Porphyrins and Is Killed by Visible Light
Viveiros, J.; Ahmadi, A.; Ganz, R. A.; Tolkoff, M. J.; Hamblin, Michael; Yang, Changming (American Society for Microbiology, 2005-06-24)Helicobacter pylori colonizes the mucus layer of the human stomach and duodenum, causes chronic gastritis, gastric ulcer, and is a risk factor for gastric adenocarcinoma. There is a 20% failure rate in antibiotic therapy, ... -
Human Platelet-Rich Plasma- and Extracellular Matrix-Derived Peptides Promote Impaired Cutaneous Wound Healing In Vivo
Demidova-Rice, Tatiana; Wolf, Lindsey; Deckenback, Jeffry; Hamblin, Michael; Herman, Ira M. (Public Library of Science, 2012)Previous work in our laboratory has described several pro-angiogenic short peptides derived from endothelial extracellular matrices degraded by bacterial collagenase. Here we tested whether these peptides could stimulate ... -
Infrared Radiative Properties and Thermal Modeling of Ceramic-Embedded Textile Fabrics
Anderson, David M.; Fessler, John R.; Pooley, Matthew A.; Seidel, Scott; Beckham, Haskell W.; Brennan, James F.; Hamblin, Michael (The Optical Society, 2017-02-21)The infrared optical properties of textiles are of great importance in numerous applications, including infrared therapy and body thermoregulation. Tuning the spectral response of fabrics by the engineering of composite ...