Browsing by Author "Johnson, Welkin Eric"
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Evolution of a TRIM5-CypA Splice Isoform in Old World Monkeys
Newman, Ruchi M.; Hall, Laura R; Kirmaier, Andrea; Pozzi, Lu-Ann; Pery, Erez; Farzan, Michael Reynolds; O'Neil, Shawn P.; Johnson, Welkin Eric (Public Library of Science, 2008)The TRIM family proteins share a conserved arrangement of three adjacent domains, an N-terminal RING domain, followed by one or two B-boxes and a coiled-coil, which constitutes the tripartite-motif for which the family is ... -
Protection Against Highly Pathogenic SIV by BCG-SIV Recombinant Priming and Attenuated Replicating Vaccinia-SIV Recombinant Boosting
Sakawaki, H; Miura, T; Igarashi, T; Horibata, S; Yokomizo, K; Matsuo, K; Yamamoto, N; Fofana, IB; Ohashi, T; Shida, H; Zhang, X; Johnson, Welkin Eric (BioMed Central, 2012) -
Refinement of Primate Copy Number Variation Hotspots Identifies Candidate Genomic Regions Evolving Under Positive Selection
Babb, Paul L; Iskow, Rebecca C; Mills, Ryan E; Ionita-Laza, Iuliana; Gokcumen, Omer; Zhu, Qihui; Shi, Xinghua; Vallender, Eric; Clark, Andrew G.; Johnson, Welkin Eric; Lee, Charles (BioMed Central, 2011)Background: Copy number variants (CNVs), defined as losses and gains of segments of genomic DNA, are a major source of genomic variation. Results: In this study, we identified over 2,000 human CNVs that overlap with ... -
Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain Variants
McNatt, Matthew W.; Zang, Trinity; Hatziioannou, Theodora; Bartlett, Mackenzie; Fofana, Ismael Farouck; Johnson, Welkin Eric; Neil, Stuart J. D.; Bieniasz, Paul D. (Public Library of Science, 2009)Tetherin/BST-2/CD317 is a recently identified antiviral protein that blocks the release of nascent retrovirus, and other virus, particles from infected cells. An HIV-1 accessory protein, Vpu, acts as an antagonist of ... -
Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2
Jia, Bin; Serra-Moreno, Ruth; Neidermyer, William James; Rahmberg, Andrew; Mackey, John J.; Fofana, Ismael Farouck; Johnson, Welkin Eric; Westmoreland, Susan V.; Evans, David T. (Public Library of Science, 2009)Tetherin, also known as BST2, CD317 or HM1.24, was recently identified as an interferon-inducible host–cell factor that interferes with the detachment of virus particles from infected cells. HIV-1 overcomes this restriction ... -
TRIM5 Suppresses Cross-Species Transmission of a Primate Immunodeficiency Virus and Selects for Emergence of Resistant Variants in the New Species
Wu, Fan; Newman, Ruchi M.; O'Connor, Shelby; Marx, Preston A.; Goldstein, Simoy; Buckler-White, Alicia; Hirsch, Vanessa M.; Kirmaier, Andrea; Hall, Laura R; Morgan, Jennifer Sauvron; Meythaler, Mareike; Kaur, Amitinder; Johnson, Welkin Eric (Public Library of Science, 2010)Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple, successful cross-species transmissions, having given rise to HIV-2 in humans, SIVmac in rhesus macaques, and SIVstm in stump-tailed ... -
Viral and Host Determinants of Primate Lentivirus Restriction by Old World Primate TRIM5alpha Proteins
McCarthy, Kevin Raymond (2014-10-21)The host restriction factor TRIM5α mediates a post-entry, pre-integration block to retroviral infection that depends upon recognition of the viral capsid by the TRIM5α PRYSPRY domain. The two predominant alleles of rhesus ...