Browsing by Author "Keshavan, Matcheri"
Now showing items 1-20 of 26
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Alterations in brain structures underlying language function in young adults at high familial risk for schizophrenia
Francis, Alan N; Seidman, Larry Joel; Jabbar, Gul A.; Mesholam-Gately, Raquelle; Thermenos, Heidi Wencel; Juelich, Richard; Proal, Ashley; Shenton, Martha Elizabeth; Kubicki, Marek R.; Mathew, Ian; Keshavan, Matcheri S; DeLisi, Lynn E (Elsevier BV, 2012)Introduction—Neuroanatomical and cognitive alterations typical of schizophrenia (SZ) patients are observed to a lesser extent in their adolescent and adult first-degree relatives, likely reflecting neurodevelopmental ... -
Altered language network activity in young people at familial high-risk for schizophrenia
Thermenos, Heidi Wencel; Whitfield-Gabrieli, S.; Seidman, Larry Joel; Kuperberg, Gina Rosalind; Juelich, R.J.; Divatia, S.; Riley, C.; Jabbar, G.A.; Shenton, Martha Elizabeth; Kubicki, Marek R.; Manschreck, Theo Clyde; Keshavan, Matcheri S; DeLisi, Lynn E (Elsevier BV, 2013)Background—Abnormalities in language and language neural circuitry are observed in schizophrenia (SZ). Similar, but less pronounced language deficits are also seen in young first degree relatives of people with SZ, who ... -
Associations between purine metabolites and monoamine neurotransmitters in first-episode psychosis
Yao, Jeffrey K.; Dougherty, George G.; Reddy, Ravinder D.; Matson, Wayne R.; Kaddurah-Daouk, Rima; Keshavan, Matcheri S. (Frontiers Media S.A., 2013)Schizophrenia (SZ) is a biochemically complex disorder characterized by widespread defects in multiple metabolic pathways whose dynamic interactions, until recently, have been difficult to examine. Rather, evidence for ... -
Barriers, Benefits, and Beliefs of Brain Training Smartphone Apps: An Internet Survey of Younger US Consumers
Torous, John; Staples, Patrick Christian; Fenstermacher, Elizabeth Anne; Dean, Jason Aaron; Keshavan, Matcheri S (Frontiers Media SA, 2016)Background: While clinical evidence for the efficacy of brain training remains in question, numerous smartphone applications (apps) already offer brain training directly to consumers. Little is known about why consumers ... -
Cognitive Enhancement Therapy Improves Frontolimbic Regulation of Emotion in Alcohol and/or Cannabis Misusing Schizophrenia: A Preliminary Study
Wojtalik, Jessica A.; Hogarty, Susan S.; Cornelius, Jack R.; Phillips, Mary L.; Keshavan, Matcheri S.; Newhill, Christina E.; Eack, Shaun M. (Frontiers Media S.A., 2016)Individuals with schizophrenia who misuse substances are burdened with impairments in emotion regulation. Cognitive enhancement therapy (CET) may address these problems by enhancing prefrontal brain function. A small sample ... -
Cognitive Remediation in Schizophrenia
Kaneko, Yoshio Arturo; Keshavan, Matcheri S (Korean College of Neuropsychopharmacology, 2012)Cognitive deficits in schizophrenia are pervasive, severe, and largely independent of the positive and negative symptoms of the illness. These deficits are increasingly considered to be core features of schizophrenia with ... -
Cognitive remediation versus active computer control in bipolar disorder with psychosis: study protocol for a randomized controlled trial
Lewandowski, Kathryn Eve; Sperry, Sarah H.; Ongur, Dost; Cohen, Bruce M.; Norris, Lesley A.; Keshavan, Matcheri S. (BioMed Central, 2016)Background: Cognitive dysfunction is a major feature of bipolar disorder with psychosis and is strongly associated with functional outcomes. Computer-based cognitive remediation has shown promise in improving cognition in ... -
Correlations Between Brain Structure and Symptom Dimensions of Psychosis in Schizophrenia, Schizoaffective, and Psychotic Bipolar I Disorders
Padmanabhan, Jaya; Tandon, N.; Haller, Chiara S; Mathew, I. T.; Eack, S. M.; Clementz, B. A.; Pearlson, G. D.; Sweeney, John; Tamminga, C. A.; Keshavan, Matcheri S (Oxford University Press (OUP), 2014)Introduction: Structural alterations may correlate with symptom severity in psychotic disorders, but the existing literature on this issue is heterogeneous. In addition, it is not known how cortical thickness and cortical ... -
Decreased axial diffusivity within language connections: A possible biomarker of schizophrenia risk
Kubicki, Marek R.; Shenton, Martha Elizabeth; Maciejewski, P; Pelavin, P.E.; Hawley, K.J.; Ballinger, T.; Swisher, T.; Jabbar, G.A.; Thermenos, Heidi Wencel; Keshavan, Matcheri S; Seidman, Larry Joel; DeLisi, Lynn E (Elsevier BV, 2013)Siblings of patients diagnosed with schizophrenia are at elevated risk for developing this disorder. The nature of such risk associated with brain abnormalities, and whether such abnormalities are similar to those observed ... -
Digital mental health apps and the therapeutic alliance: initial review
Philip, Henson; Wisniewski, Hannah; Chris, Hollis; Keshavan, Matcheri; Torous, John (Royal College of Psychiatrists, 2019-01-29)Background As mental healthcare expands to smartphone apps and other technologies that may offer therapeutic interventions without a therapist involved, it is important to assess the impact of non-traditional therapeutic ... -
Dysregulation of DGCR6 and DGCR6L: Psychopathological Outcomes in Chromosome 22q11.2 Deletion Syndrome
Chakraborty, D; Bernal, A J; Schoch, K; Howard, T. D.; Ip, E H; Hooper, S R; Keshavan, Matcheri S.; Jirtle, R L; Shashi, V (Nature Publishing Group, 2012)Chromosome 22q11.2 deletion syndrome (22q11DS) is the most common microdeletion syndrome in humans. It is typified by highly variable symptoms, which might be explained by epigenetic regulation of genes in the interval. ... -
Frequency and pattern of childhood symptom onset reported by first episode schizophrenia and clinical high risk youth
Woodberry, Kristen Anne; Serur, Rachael A.; Hallinan, Sean B.; Mesholam-Gately, Raquelle; Giuliano, Anthony J.; Wojcik, Joanne Doller; Keshavan, Matcheri S; Frazier, Jean A.; Goldstein, Jill M.; Shenton, Martha Elizabeth; McCarley, Robert William; Seidman, Larry Joel (Elsevier BV, 2014)Background—Psychosis prevention and early intervention efforts in schizophrenia have focused increasingly on sub-threshold psychotic symptoms in adolescents and young adults. Although many youth report symptom onset prior ... -
Fronto-Limbic Brain Dysfunction during the Regulation of Emotion in Schizophrenia
Eack, Shaun M.; Wojtalik, Jessica A.; Barb, Scott M.; Newhill, Christina E.; Keshavan, Matcheri S.; Phillips, Mary L. (Public Library of Science, 2016)Schizophrenia is characterized by significant and widespread impairments in the regulation of emotion. Evidence is only recently emerging regarding the neural basis of these emotion regulation impairments, and few studies ... -
Homeostatic Imbalance of Purine Catabolism in First-Episode Neuroleptic-Naïve Patients with Schizophrenia
Yao, Jeffrey K.; Dougherty, George G.; Reddy, Ravinder D.; Keshavan, Matcheri S; Montrose, Debra M.; Matson, Wayne R.; McEvoy, Joseph; Kaddurah-Daouk, Rima (Public Library of Science, 2010)Background: Purine catabolism may be an unappreciated, but important component of the homeostatic response of mitochondria to oxidant stress. Accumulating evidence suggests a pivotal role of oxidative stress in schizophrenia ... -
Joint Coupling of Awake EEG Frequency Activity and MRI Gray Matter Volumes in the Psychosis Dimension: A BSNIP Study
Soh, Pauline; Narayanan, Balaji; Khadka, Sabin; Calhoun, Vince D.; Keshavan, Matcheri S.; Tamminga, Carol A.; Sweeney, John A.; Clementz, Brett A.; Pearlson, Godfrey D. (Frontiers Media S.A., 2015)Background: Many studies have examined either electroencephalogram (EEG) frequency activity or gray matter volumes (GMV) in various psychoses [including schizophrenia (SZ), schizoaffective (SZA), and psychotic bipolar ... -
Large-Scale Fusion of Gray Matter and Resting-State Functional MRI Reveals Common and Distinct Biological Markers across the Psychosis Spectrum in the B-SNIP Cohort
Wang, Zheng; Meda, Shashwath A.; Keshavan, Matcheri S.; Tamminga, Carol A.; Sweeney, John A.; Clementz, Brett A.; Schretlen, David J.; Calhoun, Vince D.; Lui, Su; Pearlson, Godfrey D. (Frontiers Media S.A., 2015)To investigate whether aberrant interactions between brain structure and function present similarly or differently across probands with psychotic illnesses [schizophrenia (SZ), schizoaffective disorder (SAD), and bipolar ... -
Lipidomics Reveals Early Metabolic Changes in Subjects with Schizophrenia: Effects of Atypical Antipsychotics
McEvoy, Joseph; Baillie, Rebecca A.; Zhu, Hongjie; Buckley, Peter; Keshavan, Matcheri S.; Nasrallah, Henry A.; Dougherty, George G.; Yao, Jeffrey K.; Kaddurah-Daouk, Rima (Public Library of Science, 2013)There is a critical need for mapping early metabolic changes in schizophrenia to capture failures in regulation of biochemical pathways and networks. This information could provide valuable insights about disease mechanisms, ... -
A Longitudinal Pilot Proton MRS Investigation of the Manic and Euthymic States of Bipolar Disorder
Brady, Roscoe Owen; Cooper, Anne; Jensen, John Eric; Tandon, Neeraj; Cohen, Bruce Michael; Renshaw, Perry Franklin; Keshavan, Matcheri S; Öngür, Dost (Nature Publishing Group, 2012)Several lines of evidence implicate dysfunction in brain energy production as a key component of bipolar disorder. In particular, elevated brain lactate levels observed in this condition suggest a shift from aerobic to ... -
N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth
Gonzalez-Heydrich, Joseph; Bosquet Enlow, Michelle; D'Angelo, Eugene; Seidman, Larry J.; Gumlak, Sarah; Kim, April; Woodberry, Kristen A.; Rober, Ashley; Tembulkar, Sahil; O'Donnell, Kyle; Hamoda, Hesham M.; Kimball, Kara; Rotenberg, Alexander; Oberman, Lindsay M.; Pascual-Leone, Alvaro; Keshavan, Matcheri S.; Duffy, Frank H. (Hindawi Publishing Corporation, 2016)Highly penetrant mutations leading to schizophrenia are enriched for genes coding for N-methyl-D-aspartate receptor signaling complex (NMDAR-SC), implicating plasticity defects in the disease's pathogenesis. The importance ... -
New dimensions and new tools to realize the potential of RDoC: digital phenotyping via smartphones and connected devices
Torous, John B.; Onnela, J-P; Keshavan, Matcheri S (Springer Nature, 2017)Mobile and connected devices like smartphones and wearable sensors can facilitate the collection of novel naturalistic and longitudinal data relevant to psychiatry at both the personal and population level. The National ...