Browsing by Author "Nahed, Brian"

Now showing items 1-20 of 24

    • Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression 

      Sullivan, James P; Nahed, Brian Vala; Madden, M. W.; Oliveira, S. M.; Springer, S.; Bhere, Deepak; Chi, A. S.; Wakimoto, Hiroaki; Rothenberg, S. M.; Sequist, Lecia VanDam; Kapur, R.; Shah, Khalid A.; Iafrate, Anthony John; Curry, William Thomas; Loeffler, Jay Steven; Batchelor, Tracy Todd; Louis, David N.; Toner, Mehmet; Maheswaran, Shyamala; Haber, Daniel Arie (American Association for Cancer Research (AACR), 2014)
      Glioblastoma (GBM) is a highly aggressive brain cancer characterized by local invasion and angiogenic recruitment, yet metastatic dissemination is extremely rare. Here, we adapted a microfluidic device to deplete hematopoietic ...

    • Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection 

      Kahle, Kristopher; Walcott, Brian; Nahed, Brian Vala; Barnard, Zachary R.; Lo, Eng H.; Buonanno, Ferdinando Stelio; Venna, Nagagopal; Ning, MingMing (Elsevier BV, 2011)
      Acute encephalitis, encephalopathy, and seizures are known rare neurologic sequelae of respiratory tract infection with seasonal influenza A and B virus, but the neurological complications of the pandemic 2009 swine influenza ...

    • Clinical features of brain metastasis from salivary gland tumors 

      Venteicher, Andrew S; Walcott, Brian; Sheth, Sameer A.; Snuderl, Matija; Patel, Anoop Premswaroop; Curry, William Thomas; Nahed, Brian Vala (Elsevier BV, 2013)
      Salivary gland tumors comprise a group of 24 tumor subtypes with a wide range of clinical behaviors and propensities for metastasis. Several prognostic factors have been identified that help predict the development of ...

    • Conflict of Interest in Spine Research Reporting 

      Walcott, Brian Patrick; Sheth, Sameer Anil; Nahed, Brian Vala; Coumans, Jean-Valery C E (Public Library of Science, 2012)
      Background: Medical studies are more likely to report favorable findings when a conflict of interest is declared. We aim to quantify and determine the effect of author disclosure of conflict of interest on scientific ...

    • Craniectomy for Malignant Cerebral Infarction: Prevalence and Outcomes in US Hospitals 

      Walcott, Brian; Kuklina, Elena V.; Nahed, Brian Vala; George, Mary G.; Kahle, Kristopher; Simard, J. Marc; Asaad, Wael F.; Coumans, Jean-Valery C E (Public Library of Science (PLoS), 2011)
      Object: Randomized trials have demonstrated the efficacy of craniectomy for the treatment of malignant cerebral edema following ischemic stroke. We sought to determine the prevalence and outcomes related to this by using ...

    • Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq 

      Venteicher, Andrew S; Tirosh, Itay; Hebert, Christine; Yizhak, Keren; Neftel, Cyril Ralf Alexander; Filbin, Mariella Gruber; Hovestadt, Volker; Escalante, Leah; Shaw, McKenzie; Rodman, Christopher Jiahn-Leh; Gillespie, Shawn; Dionne, Danielle; Luo, Christina; Ravichandran, Hiranmayi; Mylvaganam, Ravindra; Mount, Christopher; Onozato, Maristela Lika; Nahed, Brian Vala; Wakimoto, Hiroaki; Curry, William Thomas; Iafrate, Anthony John; Rivera, Miguel Nicolas; Frosch, Matthew P.; Golub, Todd Robert; Brastianos, Priscilla Kalliope; Getz, Gad A; Patel, Anoop Premswaroop; Monje, Michelle; Cahill, Daniel P.; Rozenblatt-Rosen, Orit; Louis, David N.; Bernstein, Bradley E.; Regev, Aviv; Suvà, Mario (American Association for the Advancement of Science (AAAS), 2017)

    • Deep brain stimulation for medically refractory life-threatening status dystonicus in children 

      Walcott, Brian; Nahed, Brian Vala; Kahle, Kristopher; Duhaime, Ann-Christine; Sharma, Nutan; Eskandar, Emad (Journal of Neurosurgery Publishing Group (JNSPG), 2012)
      Generalized dystonic syndromes may escalate into persistent episodes of generalized dystonia known as status dystonicus that can be life-threatening due to dystonia-induced rhabdomyolysis and/or respiratory compromise. ...

    • Interfacility Helicopter Ambulance Transport of Neurosurgical Patients: Observations, Utilization, and Outcomes from a Quaternary Level Care Hospital 

      Walcott, Brian; Coumans, Jean-Valery C E; Mian, Matthew Kamal; Nahed, Brian Vala; Kahle, Kristopher (Public Library of Science (PLoS), 2011)
      Background: The clinical benefit of helicopter transport over ground transportation for interfacility transport is unproven. We sought to determine actual practice patterns, utilization, and outcomes of patients undergoing ...

    • Investigating the Scope of Resident Patient Care Handoffs within Neurosurgery 

      Babu, Maya A.; Nahed, Brian Vala; Heary, Robert F. (Public Library of Science (PLoS), 2012)
      Introduction: Handoffs are defined as verbal and written communications during patient care transitions. With the passage of recent ACMGE work hour rules further limiting the hours interns can spend in the hospital, many ...

    • Malpractice Liability and Defensive Medicine: A National Survey of Neurosurgeons 

      Nahed, Brian Vala; Babu, Maya A.; Smith, Timothy R.; Heary, Robert F. (Public Library of Science (PLoS), 2012)
      Background: Concern over rising healthcare expenditures has led to increased scrutiny of medical practices. As medical liability and malpractice risk rise to crisis levels, the medical-legal environment has contributed to ...

    • Multimodal Therapy of an Intramedullary Cervical Primitive Neuroectodermal Tumor in an Adult 

      Coumans, Jean-Valery C E; Walcott, B. P.; Nahed, Brian Vala; Oh, Kevin Shawn; Chi, Anthony Wei Shine (American Society of Clinical Oncology (ASCO), 2012)
      Primitive neuroectodermal tumors (PNETs) are malignant, poorly differentiated neoplasms derived from the neural crest.1 They include cerebellar medulloblastomas but can also arise in the cerebral cortex (supratentorial ...

    • Postoperative Intensive Care Unit Requirements After Elective Craniotomy 

      Hanak, Brian W.; Walcott, Brian; Nahed, Brian Vala; Muzikansky, Alona; Mian, Matthew Kamal; Kimberly, William Taylor; Curry, William Thomas (Elsevier BV, 2014)
      Objective: Commonly, patients undergoing craniotomy are admitted to an intensive care setting post-operatively to allow for close monitoring. We aim to determine the frequency with which patients who have undergone elective ...

    • Radiation Treatment for WHO Grade II and III Meningiomas 

      Walcott, Brian P.; Nahed, Brian V.; Brastianos, Priscilla K.; Loeffler, Jay S. (Frontiers Media S.A., 2013)
      The treatment of meningiomas is tailored to their histological grade. While World Health Organization (WHO) grade I lesions can be treated with either surgery or external beam radiation, WHO Grade II and III lesions often ...

    • Rapid Intraoperative Molecular Characterization of Glioma 

      Shankar, Ganesh Mani; Francis, Joshua M.; Rinne, Mikael Lee; Ramkissoon, Shakti; Huang, Franklin W; Venteicher, Andrew S; Akama-Garren, Elliot H.; Kang, Yun Jee; Lelic, Nina; Kim, James C.; Brown, Loreal E.; Charbonneau, Sarah K; Golby, Alexandra Jacqueline; Sekhar Pedamallu, Chandra; Hoang, Mai P; Sullivan, Ryan Joseph; Cherniack, Andrew D.; Garraway, Levi Alexander; Stemmer-Rachamimov, Anat; Reardon, David Allen; Wen, Patrick Yung Chih; Brastianos, Priscilla Kalliope; Curry, William Thomas; Barker, Frederick George; Hahn, William Chun; Nahed, Brian Vala; Ligon, Keith Lloyd; Louis, David N.; Cahill, Daniel P.; Meyerson, Matthew Langer (American Medical Association (AMA), 2015)
      IMPORTANCE: Conclusive intraoperative pathologic confirmation of diffuse infiltrative glioma guides the decision to pursue definitive neurosurgical resection. Establishing the intraoperative diagnosis by histologic analysis ...

    • Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells 

      Suva, Mario Luca; Rheinbay, Esther; Gillespie, Shawn M.; Patel, Anoop Premswaroop; Wakimoto, Hiroaki; Rabkin, Samuel David; Riggi, Nicolo; Chi, Anthony Wei Shine; Cahill, Daniel P.; Nahed, Brian Vala; Curry, William Thomas; Martuza, Robert Lawrence; Rivera, Miguel Nicolas; Rossetti, Nikki; Kasif, Simon; Beik, Samantha Petrillo; Kadri, Sabah; Tirosh, Itay; Wortman, Ivo; Shalek, Alex K.; Rozenblatt-Rosen, Orit; Regev, Aviv; Louis, David N.; Bernstein, Bradley E. (Elsevier BV, 2014)
      Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on cellular hierarchies ...

    • Retrievable stent thrombectomy in the treatment of acute ischemic stroke: Analysis of a revolutionizing treatment technique 

      Walcott, Brian; Boehm, Kevin M.; Stapleton, Christopher James; Mehta, Brijesh P.; Nahed, Brian Vala; Ogilvy, Christopher S. (Elsevier BV, 2013)
      Acute ischemic stroke resulting from intracranial vessel occlusion is associated with high morbidity and mortality. The mainstays of therapy are fibrinolytics and mechanical thrombectomy in properly selected patients. A ...

    • Reversal of warfarin associated coagulopathy with 4-factor prothrombin complex concentrate in traumatic brain injury and intracranial hemorrhage 

      Yanamadala, Vijay; Walcott, Brian; Fecci, Peter; Rozman, Peter; Kumar, Jay Inder; Nahed, Brian Vala; Swearingen, Brooke (Elsevier BV, 2014)
      Warfarin-associated intracranial hemorrhage is associated with a high mortality rate. Ongoing coagulopathy increases the likelihood of hematoma expansion and can result in catastrophic hemorrhage if surgery is performed ...

    • Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma 

      Patel, Anoop Premswaroop; Tirosh, I.; Trombetta, J. J.; Shalek, Alexander Kann; Gillespie, S. M.; Wakimoto, Hiroaki; Cahill, Daniel P.; Nahed, Brian Vala; Curry, William Thomas; Martuza, Robert Lawrence; Louis, David N.; Rozenblatt-Rosen, O.; Suva, Mario Luca; Regev, A.; Bernstein, Bradley E. (American Association for the Advancement of Science (AAAS), 2014)
      Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes and epigenetic states, but current models do not adequately reflect tumor composition in patients. We used single cell RNA-seq to ...

    • Socioeconomic Status Correlates with the Prevalence of Advanced Coronary Artery Disease in the United States 

      Bashinskaya, Bronislava; Nahed, Brian Vala; Walcott, Brian Patrick; Coumans, Jean-Valery C E; Onuma, Oyere Kalu (Public Library of Science, 2012)
      Background: Increasingly studies have identified socioeconomic factors adversely affecting healthcare outcomes for a multitude of diseases. To date, however, there has not been a study correlating socioeconomic details ...

    • Sporadic hemangioblastomas are characterized by cryptic VHL inactivation 

      Shankar, Ganesh Mani; Taylor-Weiner, Amaro; Lelic, Nina; Jones, Robert T; Kim, James C; Francis, Joshua M; Abedalthagafi, Malak S; Borges, Lawrence Francis; Coumans, Jean-Valery C E; Curry, William Thomas; Nahed, Brian Vala; Shin, John H; Paek, Sun Ha; Park, Sung-Hye; Stewart, Chip; Lawrence, Michael S; Cibulskis, Kristian; Thorner, Aaron R; Van Hummelen, Paul; Stemmer-Rachamimov, Anat; Batchelor, Tracy Todd; Carter, Scott Lambert; Hoang, Mai P; Santagata, Sandro; Louis, David N.; Barker, Frederick George; Meyerson, Matthew Langer; Getz, Gad A; Brastianos, Priscilla Kalliope; Cahill, Daniel P. (Springer Nature, 2014)
      Hemangioblastomas consist of 10-20% neoplastic “stromal” cells within a vascular tumor cell mass of reactive pericytes, endothelium and lymphocytes. Familial cases of central nervous system hemangioblastoma uniformly result ...