Now showing items 1-6 of 6

    • Caveolin-1 Associated Adenovirus Entry into Human Corneal Cells 

      Yousuf, Mohammad A.; Zhou, Xiaohong; Mukherjee, Santanu; Chintakuntlawar, Ashish V.; Lee, Jeong Yoon; Ramke, Mirja; Chodosh, James; Rajaiya, Jaya (Public Library of Science, 2013)
      The cellular entry of viruses represents a critical area of study, not only for viral tropism, but also because viral entry dictates the nature of the immune response elicited upon infection. Epidemic keratoconjunctivitis ...
    • Epidemic Keratoconjunctivitis-Causing Adenoviruses Induce MUC16 Ectodomain Release To Infect Ocular Surface Epithelial Cells 

      Menon, Balaraj B.; Zhou, Xiaohong; Spurr-Michaud, Sandra; Rajaiya, Jaya; Chodosh, James; Gipson, Ilene K. (American Society for Microbiology, 2016)
      ABSTRACT Human adenoviruses (HAdV), species D in particular (HAdV-D), are frequently associated with epidemic keratoconjunctivitis (EKC). Although the infection originates at the ocular surface epithelium, the mechanisms ...
    • Molecular evolution of human adenoviruses 

      Robinson, Christopher; Singh, Gurdeep; Lee, Jeong Yoon; Dehghan, Shoaleh; Rajaiya, Jaya; Liu, Elizabeth B.; Yousuf, Mohammad Abu; Betensky, Rebecca Aubrey; Jones, Morris S.; Dyer, David W.; Seto, Donald; Chodosh, James (Nature Publishing Group, 2013)
      The recent emergence of highly virulent human adenoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny. Here we report complete high quality genome sequences and analyses for all the ...
    • Predicting the Next Eye Pathogen: Analysis of a Novel Adenovirus 

      Robinson, Christopher; Zhou, Xiaohong; Rajaiya, Jayabarathy; Yousuf, Mohammad Abu; Singh, Gurdeep; DeSerres, Joshua J.; Walsh, Michael P.; Wong, Sallene; Seto, Donald; Dyer, David W.; Chodosh, James; Jones, Morris S. (American Society of Microbiology, 2013)
      For DNA viruses, genetic recombination, addition, and deletion represent important evolutionary mechanisms. Since these genetic alterations can lead to new, possibly severe pathogens, we applied a systems biology approach ...
    • Specific NFκB Subunit Activation and Kinetics of Cytokine Induction in Adenoviral Keratitis 

      Rajaiya, Jayabarathy; Sadeghi, Neda; Chodosh, James (Molecular Vision, 2009)
      Purpose: Corneal inflammation associated with ocular adenoviral infection is caused by leukocytic infiltration of the subepithelial stroma in response to expression of interleukin-8 (IL-8) and monocyte chemoattractant ...
    • Viral Capsid Is a Pathogen-Associated Molecular Pattern in Adenovirus Keratitis 

      Chintakuntlawar, Ashish V.; Zhou, Xiaohong; Rajaiya, Jayabarathy; Chodosh, James (Public Library of Science, 2010)
      Human adenovirus (HAdV) infection of the human eye, in particular serotypes 8, 19 and 37, induces the formation of corneal subepithelial leukocytic infiltrates. Using a unique mouse model of adenovirus keratitis, we studied ...