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    • Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML 

      Huang, Ju; Liu, Yuanfeng; Au, Bryan C; Barber, Dwayne L; Arruda, Andrea; Schambach, Axel; Rothe, Michael; Minden, Mark D; Paige, Christopher J; Medin, Jeffrey A (Nature Publishing Group, 2016)
      Interleukin-12 (IL-12) is a potent cytokine that may be harnessed to treat cancer. To date, nearly 100 IL-12-based clinical trials have been initiated worldwide. Yet systemic administration of IL-12 is toxic. Different ...