Now showing items 1-8 of 8

    • Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism 

      Lerin, Carles; Goldfine, Allison B.; Boes, Tanner; Liu, Manway; Kasif, Simon; Dreyfuss, Jonathan M.; De Sousa-Coelho, Ana Luisa; Daher, Grace; Manoli, Irini; Sysol, Justin R.; Isganaitis, Elvira; Jessen, Niels; Goodyear, Laurie J.; Beebe, Kirk; Gall, Walt; Venditti, Charles P.; Patti, Mary-Elizabeth (Elsevier, 2016)
      Objective: Plasma levels of branched-chain amino acids (BCAA) are consistently elevated in obesity and type 2 diabetes (T2D) and can also prospectively predict T2D. However, the role of BCAA in the pathogenesis of insulin ...
    • The Great Debate: Medicine or Surgery. What Is Best for the Patient with Type 2 Diabetes? 

      Lautz, David; Halperin, Florencia; Goebel-Fabbri, Ann Elizabeth; Goldfine, Allison Braunwald (American Diabetes Association, 2011)
    • The Impact of Salsalate Treatment on Serum Levels of Advanced Glycation End Products in Type 2 Diabetes 

      Barzilay, Joshua I.; Jablonski, Kathleen A.; Fonseca, Vivian; Shoelson, Steven E.; Goldfine, Allison B.; Strauch, Christopher; Monnier, Vincent M. (American Diabetes Association, 2014)
      OBJECTIVE Salsalate is a nonacetylated salicylate that lowers glucose levels in people with type 2 diabetes (T2D). Here we examined whether salsalate also lowered serum-protein-bound levels of early and advanced glycation ...
    • Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans 

      Halperin, Florencia; Lopez, Ximena; Manning, Raquel; Kahn, C. Ronald; Kulkarni, Rohit Narayan; Goldfine, Allison Braunwald (American Diabetes Association, 2012)
      Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell dysfunction, the latter possibly caused by a defect in insulin signaling in β-cells. We hypothesized that insulin’s effect to potentiate ...
    • New Lessons From Gastric Bypass: Impact of Glucose-Independent Islet Function 

      Goldfine, Allison B.; Patti, Mary Elizabeth (2015)
      Graphical Abstract
    • Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized? 

      Eckel, Robert H.; Kahn, Steven E.; Ferrannini, Ele; Schwartz, Michael W.; Smith, Steven R.; Goldfine, Allison Braunwald; Nathan, David Matthew; Smith, Robert J. (American Diabetes Association, 2011)
      Objective: This report examines what is known about the relationship between obesity and type 2 diabetes and how future research in these areas might be directed to benefit prevention, interventions, and overall patient ...
    • Protective Unfolded Protein Response in Human Pancreatic Beta Cells Transplanted into Mice 

      Kennedy, Jeffrey; Katsuta, Hitoshi; Jung, Min-Ho; Marselli, Lorella; Goldfine, Allison Braunwald; Balis, Ulysses J.; Sgroi, Dennis Charles; Bonner-Weir, Susan; Weir, Gordon Campbell (Public Library of Science, 2010)
      Background: There is great interest about the possible contribution of ER stress to the apoptosis of pancreatic beta cells in the diabetic state and with islet transplantation. Methods and Findings: Expression of genes ...
    • The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes 

      Walford, Geoffrey A.; Colomo, Natalia; Todd, Jennifer N.; Billings, Liana K.; Fernandez, Marlene; Chamarthi, Bindu; Warner, A. Sofia; Davis, Jaclyn; Littleton, Katherine R.; Hernandez, Alicia M.; Fanelli, Rebecca R.; Lanier, Amelia; Barbato, Corinne; Ackerman, Rachel J.; Khan, Sabina Q.; Bui, Rosa; Garber, Laurel; Stolerman, Elliot S.; Moore, Allan F.; Huang, Chunmei; Kaur, Varinderpal; Harden, Maegan; Taylor, Andrew; Chen, Ling; Manning, Alisa K.; Huang, Paul; Wexler, Deborah; McCarthy, Rita M.; Lo, Janet; Thomas, Melissa K.; Grant, Richard W.; Goldfine, Allison; Hudson, Margo S.; Florez, Jose C. (Public Library of Science, 2015)
      Objective: Genome-wide association studies have uncovered a large number of genetic variants associated with type 2 diabetes or related phenotypes. In many cases the causal gene or polymorphism has not been identified, and ...